She lit up our screens in the iconic HBO series, The Sopranos and now she is inspiring people by opening up about her health journey.

Jamie-Lynn Sigler joins Sophia for an emotional chat about getting the role of a lifetime at 16 years of age, dealing with health problems at the height of her career, why she kept her diagnosis a secret, and the many women who helped her on her journey.

Plus, the actress tells all about her new podcast with Christina Applegate and the special bond they share.