Angela talks to Dr Alessandra Zonari the chief scientific officer and founding member of OneSkin. They explore the critical role of collagen in maintaining youthful skin, the impact of senescent cells—often referred to as "zombie cells"—on skin health, and how OneSkin's innovative OSO-1 peptide targets these cells to promote collagen production and improve skin function.

Dr. Zonari also shares her journey from academia to developing groundbreaking skincare solutions, emphasising the importance of a holistic approach to skin health that includes lifestyle factors such as diet, sleep, and sun protection.

KEY TAKEAWAYS

• Biological Age of Skin: The skin around the eyes ages 20-30 years faster than other facial areas due to damage and collagen breakdown.
• Senescent Cells and Aging: Senescent cells secrete inflammation, speeding up collagen degradation and skin aging. Removing these cells improves skin health.
• The OS01 Peptide: A novel molecule that reduces senescent cells, enhances collagen production, and promotes younger, healthier skin.
• Lifestyle and Skin Health: Balanced nutrition, hydration, quality sleep, and sun protection significantly affect skin aging.
• Complementary Practices: Techniques like microneedling, red light therapy, and proper skincare routines amplify product effectiveness.

TIMESTAMPS AND KEY TOPICS

• 0:05 – Biological age differences in skin areas.
• 4:51 – Introduction to Dr. Alessandra Zonari and her background.
• 7:21 – Overview of how skin ages.
• 12:03 – Estrogen's role in collagen production.
• 22:50 – Explanation of senescent cells.
• 29:37 – OS01 peptide and its impact.
• 43:51 – Ideal skincare routine for healthy, glowing skin.
• 46:00 – Lifestyle habits influencing skin aging.

VALUABLE RESOURCES

Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com

Join The High Performance Health Community

Learn more about the science behind OneSkin and save 15% with code ANGELA at oneskin.co/angela

Get 25% Off Bon Charge Red Light Therapy Face Mask

ABOUT THE GUEST

Alessandra isn’t your typical scientist. She’s a visionary with a passion for longevity, skin regeneration, and the occasional karaoke jam. Growing up in a close-knit family in Brazil, Alessandra saw her grandparents struggle with age-related diseases and soon became fascinated by the possibility of using stem cells to redefine the aging process. After earning degrees in biology and stem cell biology, and a doctorate in skin regeneration and tissue engineering, Alessandra joined OneSkin in 2017 as a founding member and Chief Scientific Officer. Her contributions include 20+ papers, 3 patents, and the development of their proprietary OS-01 peptide.

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