This March, doctors successfully transplanted a pig kidney into a person for the first time in history. Mike Curtis is the CEO of eGenesis, the company that raised the pig whose kidney was used for the procedure. Mike's problem is this: How do you genetically engineer pigs to provide organs – kidneys, hearts, livers – for people?

This March, doctors successfully transplanted a pig kidney into a person for the first time in history. Mike Curtis is the CEO of eGenesis, the company that raised the pig whose kidney was used for the procedure. Mike's problem is this: How do you genetically engineer pigs to provide organs – kidneys, hearts, livers – for people?

Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with entrepreneurs and engineers tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with&nbsp;entrepreneurs and engineers&nbsp;tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better.
iHeartMedia is the exclusive podcast partner of Pushkin Industries.

What's Your Problem?

Every week on What’s Your Problem, entrepreneurs and engineers talk about the future they’re trying to build – and the problems they have to solve to get there.

How do you take a drone delivery service you’ve built in Rwanda and make it work in North Carolina? How do you convince people to buy a house on the Internet? How do you sell thousands of dog ramps to weiner dogs all across America when a pandemic breaks the global supply chain? 

Hosted by former Planet Money host Jacob Goldstein, What’s Your Problem helps listeners understand the problems really smart people are trying to solve right now.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

The First Pig to Human Kidney Transplant

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/756e5033-2bee-4764-893f-b15c013df9c2/transcript

John Mills is the CEO and co-founder of a nonprofit called Watch Duty. His problem is this: How do you build an app to warn people when they are in immediate danger from a natural disaster? Watch Duty has millions of users and played a key role in the Los Angeles fires of 2025. In the show, John talks about how he built his app with the help of an army of volunteers, and why the government hadn’t already built something like Watch Duty.

In this episode, John explains: 
Why one-quarter of Los Angeles residents downloaded Watch Duty during the 2025 fires
Why the all-clear message matters almost as much as the initial warning
How they are expanding into flood warnings
How to decode firefighter’s radio chatter, and his favorite bit of jargon 

Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram
Email us at problem@pushkin.fm 
Follow Pushkin on Instagram, LinkedIn or X 
Listen to Jacob’s other show, Business History 
To listen to the show early and ad free, sign up for Pushkin+

John Mills is the CEO and co-founder of a nonprofit called Watch Duty. His problem is this: How do you build an app to warn people when they are in immediate danger from a natural disaster? Watch Duty has millions of users and played a key role in the Los Angeles fires of 2025. In the show, John talks about how he built his app with the help of an army of volunteers, and why the government hadn&rsquo;t already built something like Watch Duty.
In this episode, John explains:&nbsp;
<ul>
<li>Why one-quarter of Los Angeles residents downloaded Watch Duty during the 2025 fires</li>
<li>Why the all-clear message matters almost as much as the initial warning</li>
<li>How they are expanding into flood warnings</li>
<li>How to decode firefighter&rsquo;s radio chatter, and his favorite bit of jargon&nbsp;</li>
</ul>
Connect with us:
<ul>
<li>Follow Jacob Goldstein on <a href="https://www.linkedin.com/in/jacob-goldstein-888a2441/">LinkedIn</a>, <a href="https://x.com/jacobgoldstein?lang=en">X</a> and <a href="https://www.instagram.com/jacobjgoldstein/">Instagram</a></li>
<li>Email us at <a href="mailto:problem@pushkin.fm">problem@pushkin.fm</a>&nbsp;</li>
<li>Follow Pushkin on <a href="https://www.instagram.com/pushkinpods/">Instagram</a>,<a href="https://www.linkedin.com/company/pushkin-industries/posts/?feedView=all"> LinkedIn</a> or <a href="https://x.com/pushkinpods?lang=en">X</a>&nbsp;</li>
<li>Listen to Jacob&rsquo;s other show, <a href="https://podcasts.apple.com/us/podcast/business-history/id1844409167">Business History&nbsp;</a></li>
<li>To listen to the show early and ad free, sign up for <a href="https://www.pushkin.fm/join-pushkin">Pushkin+</a></li>
</ul>

Racing Wildfires to Warn the Public

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/1bcf376e-f08c-4cbe-b5b3-b47400f386e7/transcript

Josh Tyrangiel is the author of “AI for Good: How Real People Are Using Artificial Intelligence to Fix Things That Matter.” On today’s show, Josh talks about some of these real people and the problems they’re working on: a professor trying to understand her nonverbal son, a general who delivered millions of Covid vaccines in 2021, and a hospital CEO trying to reduce the rate of deadly infections. 

In this episode, Josh explains: 
Where AI is helping to reduce hospital infections (and where it’s struggling)
Why distributing the Covid vaccine was almost as hard as creating it
Why convincing people to use AI is often the hardest problem to solve 
Why we should use nuclear weapons as a model for regulating AI

Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram
Email us at problem@pushkin.fm 
Follow Pushkin on Instagram, LinkedIn or X 
Listen to Jacob’s other show, Business History 
To listen to the show early and ad free, sign up for Pushkin+

Josh Tyrangiel is the author of &ldquo;<a href="https://www.simonandschuster.com/books/AI-for-Good/Josh-Tyrangiel/9781668082508">AI for Good: How Real People Are Using Artificial Intelligence to Fix Things That Matter</a>.&rdquo; On today&rsquo;s show, Josh talks about some of these real people and the problems they&rsquo;re working on: a professor trying to understand her nonverbal son, a general who delivered millions of Covid vaccines in 2021, and a hospital CEO trying to reduce the rate of deadly infections.&nbsp;
In this episode, Josh explains:&nbsp;
<ul>
<li>Where AI is helping to reduce hospital infections (and where it&rsquo;s struggling)</li>
<li>Why distributing the Covid vaccine was almost as hard as creating it</li>
<li>Why convincing people to use AI is often the hardest problem to solve&nbsp;</li>
<li>Why we should use nuclear weapons as a model for regulating AI</li>
</ul>
Connect with us:
<ul>
<li>Follow Jacob Goldstein on <a href="https://www.linkedin.com/in/jacob-goldstein-888a2441/">LinkedIn</a>, <a href="https://x.com/jacobgoldstein?lang=en">X</a> and <a href="https://www.instagram.com/jacobjgoldstein/">Instagram</a></li>
<li>Email us at <a href="mailto:problem@pushkin.fm">problem@pushkin.fm</a>&nbsp;</li>
<li>Follow Pushkin on <a href="https://www.instagram.com/pushkinpods/">Instagram</a>,<a href="https://www.linkedin.com/company/pushkin-industries/posts/?feedView=all"> LinkedIn</a> or <a href="https://x.com/pushkinpods?lang=en">X</a>&nbsp;</li>
<li>Listen to Jacob&rsquo;s other show, <a href="https://podcasts.apple.com/us/podcast/business-history/id1844409167">Business History&nbsp;</a></li>
<li>To listen to the show early and ad free, sign up for <a href="https://www.pushkin.fm/join-pushkin">Pushkin+</a></li>
</ul>

How AI Could Actually Make the World Better

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/7e40fe0f-ce12-481f-af8d-b46d00ecab2d/transcript

Betsey Stevenson is a labor economist at the University of Michigan, and she was an economic adviser to President Obama. Betsey’s problem is this: How can we create a world where the benefits of AI are broadly shared?

Betsey draws on history – including how the invention of household appliances created a crisis of meaning for American women – to understand how we should respond to the challenge of AI. And she suggests policies to help spread the wealth AI could bring.

In this episode, Betsey explains: 
How Engels’ Pause serves as a warning for workers
How 20th century women adapted to automation
How AI has changed life for college students
The argument for taxing AI firms and distributing the proceeds to the public

Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram
Email us at problem@pushkin.fm 
Follow Pushkin on Instagram, LinkedIn or X 
Listen to Jacob’s other show, Business History 
To listen to the show early and ad free, sign up for Pushkin+

Betsey Stevenson is a labor economist at the University of Michigan, and she was an economic adviser to President Obama. Betsey&rsquo;s problem is this: How can we create a world where the benefits of AI are broadly shared?
Betsey draws on history &ndash; including how the invention of household appliances created a crisis of meaning for American women &ndash; to understand how we should respond to the challenge of AI. And she suggests policies to help spread the wealth AI could bring.
In this episode, Betsey explains:&nbsp;
<ul>
<li>How Engels&rsquo; Pause serves as a warning for workers</li>
<li>How 20th century women adapted to automation</li>
<li>How AI has changed life for college students</li>
<li>The argument for taxing AI firms and distributing the proceeds to the public</li>
</ul>
Connect with us:
<ul>
<li>Follow Jacob Goldstein on <a href="https://www.linkedin.com/in/jacob-goldstein-888a2441/">LinkedIn</a>, <a href="https://x.com/jacobgoldstein?lang=en">X</a> and <a href="https://www.instagram.com/jacobjgoldstein/">Instagram</a></li>
<li>Email us at <a href="mailto:problem@pushkin.fm">problem@pushkin.fm</a>&nbsp;</li>
<li>Follow Pushkin on <a href="https://www.instagram.com/pushkinpods/">Instagram</a>,<a href="https://www.linkedin.com/company/pushkin-industries/posts/?feedView=all"> LinkedIn</a> or <a href="https://x.com/pushkinpods?lang=en">X</a>&nbsp;</li>
<li>Listen to Jacob&rsquo;s other show, <a href="https://podcasts.apple.com/us/podcast/business-history/id1844409167">Business History&nbsp;</a></li>
<li>To listen to the show early and ad free, sign up for <a href="https://www.pushkin.fm/join-pushkin">Pushkin+</a></li>
</ul>

Finding Meaning (and Money) in the AI Age

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/2c3507bd-e1d8-477c-a235-b46d002c7641/transcript

The First Pig to Human Kidney Transplant

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