This March, doctors successfully transplanted a pig kidney into a person for the first time in history. Mike Curtis is the CEO of eGenesis, the company that raised the pig whose kidney was used for the procedure. Mike's problem is this: How do you genetically engineer pigs to provide organs – kidneys, hearts, livers – for people?

This March, doctors successfully transplanted a pig kidney into a person for the first time in history. Mike Curtis is the CEO of eGenesis, the company that raised the pig whose kidney was used for the procedure. Mike's problem is this: How do you genetically engineer pigs to provide organs – kidneys, hearts, livers – for people?

Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with entrepreneurs and engineers tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with&nbsp;entrepreneurs and engineers&nbsp;tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better.
iHeartMedia is the exclusive podcast partner of Pushkin Industries.

What's Your Problem?

Every week on What’s Your Problem, entrepreneurs and engineers talk about the future they’re trying to build – and the problems they have to solve to get there.

How do you take a drone delivery service you’ve built in Rwanda and make it work in North Carolina? How do you convince people to buy a house on the Internet? How do you sell thousands of dog ramps to weiner dogs all across America when a pandemic breaks the global supply chain? 

Hosted by former Planet Money host Jacob Goldstein, What’s Your Problem helps listeners understand the problems really smart people are trying to solve right now.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

The First Pig to Human Kidney Transplant

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/756e5033-2bee-4764-893f-b15c013df9c2/transcript

Circadian rhythm isn’t just controlled by your brain. Every cell in your body runs on a 24-hour cycle, including your muscle cells. 

Karyn Esser is the chair of the department of physiology and aging at the University of Florida, and she’s a leading expert on circadian rhythm in muscle cells. Karyn's problem is this: How does the circadian rhythm in muscle cells change as we age, and how does exercise help keep our system in sync?

In this episode, Karyn explains: 
How every cell in your body has a clock in it
How muscle clocks prepare cells for work and schedule recovery during rest
How age affects these clocks’ ability to regulate effectively 
Why exercise can improve clock function 
Why jet lag and late-night eating can put your body clocks out of sync 

Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram 
Email us at problem@pushkin.fm 
Follow Pushkin on Instagram, LinkedIn or X 
Listen to Jacob’s other show, Business History 
To listen to the show ad free, sign up for Pushkin+ 

Circadian rhythm isn&rsquo;t just controlled by your brain. Every cell in your body runs on a 24-hour cycle, including your muscle cells.&nbsp;
Karyn Esser is the chair of the department of physiology and aging at the University of Florida, and she&rsquo;s a leading expert on circadian rhythm in muscle cells. Karyn's problem is this: How does the circadian rhythm in muscle cells change as we age, and how does exercise help keep our system in sync?
In this episode, Karyn explains:&nbsp;
<ul>
<li>How every cell in your body has a clock in it</li>
<li>How muscle clocks prepare cells for work and schedule recovery during rest</li>
<li>How age affects these clocks&rsquo; ability to regulate effectively&nbsp;</li>
<li>Why exercise can improve clock function&nbsp;</li>
<li>Why jet lag and late-night eating can put your body clocks out of sync&nbsp;</li>
</ul>
Connect with us:
<ul>
<li>Follow Jacob Goldstein on <a href="https://www.linkedin.com/in/jacob-goldstein-888a2441/" data-airgap-id="11">LinkedIn</a>, <a href="https://x.com/jacobgoldstein?lang=en" data-airgap-id="12">X</a> and <a href="https://www.instagram.com/jacobjgoldstein/" data-airgap-id="13">Instagram&nbsp;</a></li>
<li>Email us at <a href="mailto:problem@pushkin.fm" data-airgap-id="14">problem@pushkin.fm</a>&nbsp;</li>
<li>Follow Pushkin on <a href="https://www.instagram.com/pushkinpods/" data-airgap-id="15">Instagram</a>,<a href="https://www.linkedin.com/company/pushkin-industries/posts/?feedView=all" data-airgap-id="16"> LinkedIn</a> or <a href="https://x.com/pushkinpods?lang=en" data-airgap-id="17">X</a>&nbsp;</li>
<li>Listen to Jacob&rsquo;s other show, <a href="https://podcasts.apple.com/us/podcast/business-history/id1844409167" data-airgap-id="18">Business History&nbsp;</a></li>
<li>To listen to the show ad free, sign up for <a href="https://www.pushkin.fm/join-pushkin" data-airgap-id="19">Pushkin+</a>&nbsp;</li>
</ul>

Every Cell in Your Body Has a Clock

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/bd02d39f-d8ab-480a-9d98-b4f101743ea7/transcript

Throughout the next few weeks, every Monday we'll be sharing some of our favorite episodes from Jacob's other show Business History. We hope you enjoy them and if you want to hear more, subscriber to Business History on Apple, Spotify or wherever you get your podcasts.

William Shockley was an electronics genius - he even won a Nobel Prize - but he was an awful boss. Shockley was a cruel, paranoid micromanager. And this annoyed the staff of brilliant young engineers he'd assembled in a quiet town in Northern California. In fact, they quit and set up a company of their own inventing silicon chips. 

Robert Noyce, Gordon Moore and the rest of "The Traitorous Eight" transformed computing, but also blazed a trail for the tech founders who would flock to Silicon Valley and change the world. Members of "The Traitorous Eight" set up Intel and AMD, while also funding businesses such as Google and Slack. 

Connect with us:
Follow Business History on Instagram and TikTok
Follow Jacob Goldstein on LinkedIn, X and Instagram 
Follow Robert Smith on Instagram and X
Email us at businesshistory@pushkin.fm 
Follow Pushkin on Instagram, LinkedIn and X 
To listen to the show ad free, sign up for Pushkin+ 

Throughout the next few weeks, every Monday we'll be sharing some of our favorite episodes from Jacob's other show Business History. We hope you enjoy them and if you want to hear more, subscriber to Business History on <a href="https://podcasts.apple.com/us/podcast/business-history/id1844409167" data-airgap-id="155">Apple</a>, <a href="https://open.spotify.com/show/0eCqHmuyMoj8NXXFHP6wIi?si=b2a62a23c83a4068" data-airgap-id="156">Spotify</a> or wherever you get your podcasts.
William Shockley was an electronics genius - he even won a Nobel Prize - but he was an awful boss. Shockley was a cruel, paranoid micromanager. And this annoyed the staff of brilliant young engineers he'd assembled in a quiet town in Northern California. In fact, they quit and set up a company of their own inventing silicon chips.&nbsp;
Robert Noyce, Gordon Moore and the rest of "The Traitorous Eight" transformed computing, but also blazed a trail for the tech founders who would flock to Silicon Valley and change the world. Members of "The Traitorous Eight" set up Intel and AMD, while also funding businesses such as Google and Slack.&nbsp;
Connect with us:
<ul>
<li>Follow Business History on <a href="https://www.instagram.com/businesshistorypod/" data-airgap-id="12">Instagram</a> and <a href="https://www.tiktok.com/@businesshistorypod" data-airgap-id="13">TikTok</a></li>
<li>Follow Jacob Goldstein on <a href="https://www.linkedin.com/in/jacob-goldstein-888a2441/" data-airgap-id="14">LinkedIn</a>, <a href="https://x.com/jacobgoldstein?lang=en" data-airgap-id="15">X</a> and <a href="https://www.instagram.com/jacobjgoldstein/" data-airgap-id="16">Instagram&nbsp;</a></li>
<li>Follow Robert Smith on <a href="https://www.instagram.com/radiosmith/" data-airgap-id="17">Instagram</a> and <a href="https://x.com/radiosmith" data-airgap-id="18">X</a></li>
<li>Email us at <a href="mailto:businesshistory@pushkin.fm" data-airgap-id="19">businesshistory@pushkin.fm</a>&nbsp;</li>
<li>Follow Pushkin on <a href="https://www.instagram.com/pushkinpods/" data-airgap-id="20">Instagram</a>,<a href="https://www.linkedin.com/company/pushkin-industries/posts/?feedView=all" data-airgap-id="21"> LinkedIn</a> and <a href="https://x.com/pushkinpods?lang=en" data-airgap-id="22">X</a>&nbsp;</li>
<li>To listen to the show ad free, sign up for <a href="https://www.pushkin.fm/join-pushkin" data-airgap-id="23">Pushkin+</a>&nbsp;</li>
</ul>

How a Bad Boss Kickstarted Silicon Valley... from Business History

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/3a0604ba-ef90-4111-a84c-b4ec015368fe/transcript

Note: Today’s show is sponsored by PayPal.

Kartik Hosanagar is a professor at the Wharton School. The problems he studies include: What will it take for people to trust AI agents to buy stuff for them? And how should businesses prepare for a world where their customers include AI agents?

In this episode, Kartik explains:
Why trust in agentic shopping will arrive category by category, not all at once
How a single old Reddit post erased a thriving brand from ChatGPT’s recommendations
Why someone needs to take on the liability risk when purchases go wrong
How treating AI as just another sales channel is the mistake the movie studios made with Netflix
How to get a language model to pay attention to your brand

Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram 
Email us at problem@pushkin.fm 
Follow Pushkin on Instagram, LinkedIn or X 
Listen to Jacob’s other show, Business History 
To listen to the show ad free, sign up for Pushkin+

Note: Today&rsquo;s show is sponsored by PayPal.
Kartik Hosanagar is a professor at the Wharton School. The problems he studies include: What will it take for people to trust AI agents to buy stuff for them? And how should businesses prepare for a world where their customers include AI agents?
In this episode, Kartik explains:
<ul>
<li>Why trust in agentic shopping will arrive category by category, not all at once</li>
<li>How a single old Reddit post erased a thriving brand from ChatGPT&rsquo;s recommendations</li>
<li>Why someone needs to take on the liability risk when purchases go wrong</li>
<li>How treating AI as just another sales channel is the mistake the movie studios made with Netflix</li>
<li>How to get a language model to pay attention to your brand</li>
</ul>
Connect with us:
<ul>
<li>Follow Jacob Goldstein on <a href="https://www.linkedin.com/in/jacob-goldstein-888a2441/" data-airgap-id="11">LinkedIn</a>, <a href="https://x.com/jacobgoldstein?lang=en" data-airgap-id="12">X</a> and <a href="https://www.instagram.com/jacobjgoldstein/" data-airgap-id="13">Instagram&nbsp;</a></li>
<li>Email us at <a href="mailto:problem@pushkin.fm" data-airgap-id="14">problem@pushkin.fm</a>&nbsp;</li>
<li>Follow Pushkin on <a href="https://www.instagram.com/pushkinpods/" data-airgap-id="15">Instagram</a>,<a href="https://www.linkedin.com/company/pushkin-industries/posts/?feedView=all" data-airgap-id="16"> LinkedIn</a> or <a href="https://x.com/pushkinpods?lang=en" data-airgap-id="17">X</a>&nbsp;</li>
<li>Listen to Jacob&rsquo;s other show, <a href="https://podcasts.apple.com/us/podcast/business-history/id1844409167" data-airgap-id="18">Business History&nbsp;</a></li>
<li>To listen to the show ad free, sign up for <a href="https://www.pushkin.fm/join-pushkin" data-airgap-id="19">Pushkin+</a></li>
</ul>

Solving the Trust Problem in AI Shopping

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/35edc104-c4f3-489a-996f-b4eb000c6d9a/transcript

The First Pig to Human Kidney Transplant

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