Drugs in Space

Paul Reichert is a research scientist at Merck, working on improvements to how we administer drugs to patients. Paul's problem is this: How can you run experiments in space to learn how to make better drugs on Earth?

The World Is Getting Better (Really)

Hannah Ritchie is a data scientist and the deputy editor of Our World in Data. She is also the author of Not the End of the World: How We Can Be the First Generation to Build a Sustainable Planet. Hannah’s problem is this: How do you use data to get past the doomsday headlines and solve big problem…

Rabies: When Monsters are Real…from Incubation

Why has rabies invaded our nightmares for centuries? Author and veterinarian Monica Murphy tells us about the cultural history of rabies (which involves vampires and werewolves!) and how our long nightmare with the disease came to an end. Then, wildlife biologist Kathy Nelson tells us about a surpr…

Using Gene Therapy to Help the Blind See

After decades of research, gene therapy is starting to work. Shannon Boye is a professor of cellular and molecular therapeutics at the University of Florida. She is also the co-founder and chief scientific officer of Atsena Therapeutics. Shannon’s problem is this: How do you use gene therapy to cur…

Bringing Back Mammoths and Dodos*

*Or at least, sort of bringing back mammoths and dodos. Beth Shapiro is the chief scientific officer at Colossal Biosciences and the author of How to Clone a Mammoth: The Science of De-Extinction. Beth's problem is this: How do you use the tools of modern biology – and hundreds of millions of doll…

What Elevators Teach Us About Technology, Design, and Human Behavior

The elevator made the modern city possible: No elevators, no skyscrapers. Today, people are working on entirely new kinds of elevators that can go higher and faster than ever. On today’s show, we talk about those innovations with Lee Gray, who is possibly the world’s leading elevator historian and …

Can the Plant Microbiome Revolutionize Farming?

The invention of synthetic fertilizer was one of the key breakthroughs of the 20th century. It’s the reason we can grow enough food to feed billions of people. It’s also super energy intensive. Karsten Temme is the co-founder and Chief Innovation Officer at Pivot Bio. Karsten's problem is this: How…

Turning Pollution into Jet Fuel

Jennifer Holmgren is the CEO of LanzaTech. Her problem is this: How do you capture pollution from factories, feed it to bacteria, and get the bacteria to produce ethanol, which can become everything from polyester to jet fuel?

Reinventing Mining to Power the World

Moving from fossil fuels to renewable energy will require huge amounts of copper, lithium, and other metals. Kurt House is the co-founder and CEO of KoBold Metals. The company recently made a huge copper discovery in Zambia, and is looking for other metals in other places. Kurt's problem is this: H…

Inventing a Vaccine for Bees

Dalial Freitak and Annette Kleiser are the co-founders of Dalan Animal Health, a company that has brought to market the first vaccine for insects. Their problem is this: How do you turn a discovery about insect immune systems into a vaccine that can protect the bees we need to grow everything from …