** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at This Medical Life, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode **

Chromosomal abnormalities are often incompatible with life. 

However, there are a few exceptions to this rule and history has shown us that certain paired chromosomes can include a third. These conditions are known today as Down syndrome (Trisomy 21), Edwards’ syndrome (Trisomy 18) and Patau syndrome (Trisomy 13). These syndromes are routinely screen for in pregnancy with NIPT (Non-Invasive Prenatal Testing).

This podcast includes an interview discussing the application of NIPT with Professor Graeme Suthers and the path ahead for foetal screening and this section of the podcast is eligible for 1 RACGP CPD point – self reporting.

Professor Graeme Suthers
BSc (Med), MBBS, PhD, FRACP, FRCPA, GAICD
clinpath.com.au/about-us/clinpath-leadership/our-pathologists/professor-graeme-suthers/

This Pathological Life is produced by Clinpath Pathology in South Australia.

** Thanks for downloading this episode. If you'd like to stay in touch with our continuing story, Season 2 continues at <a href="https://thismedicallife.com.au/">This Medical Life</a>, in which Dr Travis Brown continues his exploration of diseases and our approaches to treatment from history to the modern day. Have a look in your podcast app now for This Medical Life, and hit subscribe so you never miss an episode **
Chromosomal abnormalities are often incompatible with life. 
However, there are a few exceptions to this rule and history has shown us that certain paired chromosomes can include a third. These conditions are known today as Down syndrome (Trisomy 21), Edwards’ syndrome (Trisomy 18) and Patau syndrome (Trisomy 13). These syndromes are routinely screen for in pregnancy with NIPT (Non-Invasive Prenatal Testing).
This podcast includes an interview discussing the application of NIPT with Professor Graeme Suthers and the path ahead for foetal screening and this section of the podcast is eligible for 1 RACGP CPD point – self reporting.
Professor Graeme Suthers BSc (Med), MBBS, PhD, FRACP, FRCPA, GAICD <a href="https://www.clinpath.com.au/about-us/clinpath-leadership/our-pathologists/professor-graeme-suthers/">clinpath.com.au/about-us/clinpath-leadership/our-pathologists/professor-graeme-suthers/</a>
This Pathological Life is produced by Clinpath Pathology in South Australia.

Welcome to the This Medical Life podcast. Our mission is to share stories about the triumphs and tragedies of diseases and illnesses from ancient times up until what we know today. It is about those scientific and medical minds who came before us and how, every single day, we stand on the shoulders of giants. This is a podcast about the stories of medicine.


Hosted by Dr. Travis Brown and Steve Davis, our target audience is General Practitioners, medical students, and other health professionals. We hope to educate, inspire and celebrate those who choose to care for others in their profession. From experience, we know that our audience extends beyond these fields and would like to welcome anyone to listen. The stories of those who came before us are nothing short of remarkable and we hope you enjoy them as much as we do.

Production by Tim Whiffen

Design by Tom Buzz

This Medical Life

Auscast Medical Channel is a podcast channel that provides a wide range of medical-related content. The podcasts feature interviews with experts in various medical fields, including doctors, nurses, and other healthcare professionals, as well as discussions on the latest medical research and treatment options. The channel covers a wide range of topics, including general health, mental health, and specific medical conditions. The podcasts are aimed at both healthcare professionals and the general public, and provide listeners with the latest information and insights on healthcare topics. Auscast Medical Channel is a great resource for staying informed about medical issues and trends, and for learning more about how to care for yourself and your loved ones.

Auscast Medical Channel is a podcast channel that provides a wide range of medical-related content. The podcasts feature interviews with experts in various medical fields, including doctors, nurses, and other healthcare professionals, as well as discussions on the latest medical research and treatment options. The channel covers a wide range of topics, including general health, mental health, and specific medical conditions. The podcasts are aimed at both healthcare professionals and the general public, and provide listeners with the latest information and insights on healthcare topics. Auscast Medical Channel is a great resource for staying informed about medical issues and trends, and for learning more about how to care for yourself and your loved ones.

Auscast Medical

Ep 13 Chromosomal Abnormalities Pathology | Survivable triplicates

Act One

Act Two

Chapter Three

Scleroderma is a disease characterised by the hardening and tightening of the skin and connective tissues. The first medical description can be traced back to the 1750s.

Our understanding has evolved over the centuries but the pathogenesis remains largely unknown. The disease as several forms including diffuse and localised. Symptoms include skin discoloration and tightness to more severe complications like organ dysfunction.

Fortunately we have several different treatment options available for patients that can assist them in managing this disease.

This is the story of Scleroderma.

Our special guest: 

Our special guest is Dr. Daman Langguth, a renowned clinical and laboratory immunologist with deep expertise in autoimmune diseases. Dr. Langguth discusses the importance of recognising scleroderma’s symptoms, the critical nature of early diagnosis, and the latest advancements in treatment.

This Medical Life podcast is available on all podcasting services and Spotify. Help support us at https://www.patreon.com/ThisMedicalLife

Scleroderma is a disease characterised by the hardening and tightening of the skin and connective tissues. The first medical description can be traced back to the 1750s.
Our understanding has evolved over the centuries but the pathogenesis remains largely unknown. The disease as several forms including diffuse and localised. Symptoms include skin discoloration and tightness to more severe complications like organ dysfunction.
Fortunately we have several different treatment options available for patients that can assist them in managing this disease.
This is the story of Scleroderma.
Our special guest: 
Our special guest is Dr. Daman Langguth, a renowned clinical and laboratory immunologist with deep expertise in autoimmune diseases. Dr. Langguth discusses the importance of recognising scleroderma’s symptoms, the critical nature of early diagnosis, and the latest advancements in treatment.
This Medical Life podcast is available on all podcasting services and Spotify. Help support us at <a href="https://www.patreon.com/ThisMedicalLife">https://www.patreon.com/ThisMedicalLife</a>

Explore scleroderma's history, symptoms, and treatments with Dr. Daman Langguth on This Medical Life Podcast, Episode 59.

Episode 59: Scleroderma | Arboreal Integument

Act Three

In 1901, the state of Montana organised for scientists and doctors to investigate a mysterious illness from the Bitterroot Valley called ‘Black measles’ and ‘Black typhus’. People of all ages were affected but predominantly those who worked in the brush and were exposed to tick bites. The investigators called it ‘tick fever’ and this particular strain had a mortality rate over eighty percent.



Today this disease is known as Rocky Mountain spotted fever. In Australia, it is sometimes called ‘spotted fever’ or ‘Queensland tick typhus’. It is caused by an obligate intracellular bacterial micro-organism (needs a cell to survive). This organism is very difficult to culture and can be even more difficult to diagnose but surprisingly easy to treat. Rickettsial disease is an under-recognised infection and important in the differential diagnosis of any patients presenting with fevers, headaches and rash.



This is the story of Rickettsia

Our special guest:  

Our special guest is Professor Stephen Graves who is a medical microbiology and founder of the Australian Rickettsial Reference Laboratory (ARRL). He specialises is infectious diseases transmitted by ectoparasites such as ticks, lice, fleas and mites.



This Medical Life podcast is available on all podcasting services and Spotify.

In 1901, the state of Montana organised for scientists and doctors to investigate a mysterious illness from the Bitterroot Valley called ‘Black measles’ and ‘Black typhus’. People of all ages were affected but predominantly those who worked in the brush and were exposed to tick bites. The investigators called it ‘tick fever’ and this particular strain had a mortality rate over eighty percent.
 
Today this disease is known as Rocky Mountain spotted fever. In Australia, it is sometimes called ‘spotted fever’ or ‘Queensland tick typhus’. It is caused by an obligate intracellular bacterial micro-organism (needs a cell to survive). This organism is very difficult to culture and can be even more difficult to diagnose but surprisingly easy to treat. Rickettsial disease is an under-recognised infection and important in the differential diagnosis of any patients presenting with fevers, headaches and rash.
 
This is the story of Rickettsia
 Our special guest: 
Our special guest is Professor Stephen Graves who is a medical microbiology and founder of the Australian Rickettsial Reference Laboratory (ARRL). He specialises is infectious diseases transmitted by ectoparasites such as ticks, lice, fleas and mites.
 
This Medical Life podcast is available on all podcasting services and Spotify.

Discover the history of Rocky Mountain spotted fever, once called 'tick fever,' with Prof. Stephen Graves on This Medical Life Podcast.

Episode 58: Ticking the spotted fever box | Rickettsia

Our understanding of infectious disease and pathology stems from the 19th century with Robert Koch pioneering research. Dr Koch help to shaped modern microbiology and medicine when he identified the causative agents for anthrax and tuberculosis. Since that time, the number of infectious microorganisms that we know of that cause illness and diseases has increased exponentially. Thanks to modern day techniques, laboratories can test for these agents directly or indirectly and get an answer often within hours.

As such, microbiology is on the verge of a new era. Instead of the principle of one test: one micro-organism, we are moving into the realm where one test can detect hundreds of potential pathogens and antimicrobial resistance genes in a single stool sample. The new test is called Metapanel. This includes 175 gene targets using metagenomics (shotgun gene sequencing) and is able to detect bacteria, viruses, helminths, protozoa, fungi, microsporidia. This information is collated and reported by a pathologist and advice given as to what is the implications of the result. The test is ideally suited for patients with chronic diarrhoea, inflammatory bowel disease and/or inflammatory bowel syndrome.

This is the story of advanced faeces testing and Metapanel

** Please note: General Practitioners in Australia, will be able to claim CPD points after listening to this episode. Full details and registration, coming shortly.

Our special guest: 

Dr Michael Wehrhahn is the Director of Molecular Biology and Infectious serology at Douglass Hanly Moir Pathology. Michael has a Master in Public Health, is an Infectious Disease Specialist as well as a Microbiologist and Adjunct Senior Lecturer at the University of Notre Dame.

Dr Wehrhahn is actively involved in research on clinical and laboratory aspects of a range of microorganisms and is a reviewer for a number of journals. Michael has been involved in researching and validating the new Metapanel available through Sonic in conjunction with Microba.

This Medical Life podcast is available on all podcasting services and Spotify. Help support us at https://www.patreon.com/ThisMedicalLife

Our understanding of infectious disease and pathology stems from the 19th century with Robert Koch pioneering research. Dr Koch help to shaped modern microbiology and medicine when he identified the causative agents for anthrax and tuberculosis. Since that time, the number of infectious microorganisms that we know of that cause illness and diseases has increased exponentially. Thanks to modern day techniques, laboratories can test for these agents directly or indirectly and get an answer often within hours.
As such, microbiology is on the verge of a new era. Instead of the principle of one test: one micro-organism, we are moving into the realm where one test can detect hundreds of potential pathogens and antimicrobial resistance genes in a single stool sample. The new test is called Metapanel. This includes 175 gene targets using metagenomics (shotgun gene sequencing) and is able to detect bacteria, viruses, helminths, protozoa, fungi, microsporidia. This information is collated and reported by a pathologist and advice given as to what is the implications of the result. The test is ideally suited for patients with chronic diarrhoea, inflammatory bowel disease and/or inflammatory bowel syndrome.
This is the story of advanced faeces testing and Metapanel
** Please note: General Practitioners in Australia, will be able to claim CPD points after listening to this episode. Full details and registration, coming shortly.
Our special guest: 
Dr Michael Wehrhahn is the Director of Molecular Biology and Infectious serology at Douglass Hanly Moir Pathology. Michael has a Master in Public Health, is an Infectious Disease Specialist as well as a Microbiologist and Adjunct Senior Lecturer at the University of Notre Dame.
Dr Wehrhahn is actively involved in research on clinical and laboratory aspects of a range of microorganisms and is a reviewer for a number of journals. Michael has been involved in researching and validating the new Metapanel available through Sonic in conjunction with Microba.
This Medical Life podcast is available on all podcasting services and Spotify. Help support us at <a href="https://www.patreon.com/ThisMedicalLife">https://www.patreon.com/ThisMedicalLife</a>

Episode 57: Fantastic Faeces and Where to Find Pathogens. Dive into Metapanel, detecting hundreds of pathogens in one test, transforming diagnostics.

Ep 13 Chromosomal Abnormalities Pathology | Survivable triplicates

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