Episode 79 Hand Pathology | Osteoarthritis, Ganglion Cysts, And Carpal Tunnel Syndrome
It is evident from paintings that Leonardo da Vinci and Michelangelo suffered some form of underlying hand pathologies. These have been the focus of discussions and journal articles amongst many academics. Our understanding of different disease processes involving the hand have come a long way. The…
Episode 78: Hyponatraemia | Sodium Solutions
Hyponatraemia, the most common electrolyte disturbance in clinical medicine, is often subtle but can be serious. In this episode, we trace the surprising history of fluid replacement back to the 1832 cholera riots in Liverpool, where experimental saline saved lives amidst chaos and mistrust. We t…
Episode 77: Burkitt Lymphoma | Into The Archives
In 1958, Dr Denis Burkitt was working in Uganda when he saw multiple children with large and aggressive jaw tumours. He had never seen anything like this before and he investigated further. Over the next few years, he discovered that these tumours had a geographical distribution across equatorial A…
Episode 76: Osteoporosis | Blasts And Clasts
Osteoporosis is a disease that takes years and even decades to develop. Up to 40% of post-menopausal women are affected who have a lifetime risk of fracture of ~40%. Men aged 60 have a 25% lifetime risk of an osteoporotic fracture. Evidence also shows that patients health significantly deteriorates…
Episode 75: Ancient DNA | Humans and Neanderthals
Recent genetics studies have shown that ancient Humans and Neanderthals coexisted around 50,000 years ago for approximately 7,000 years. There is evidence of these different human species mixing and having offspring. Around 2-4% of modern humans can be traced back to Neanderthals. This is the st…
Episode 74: The Story Of Stories
And we’re back for 2025. We thought we’d ease into this season with some medical stories. From the Manhattan project and the demon core to the inspirational stories of Dr Elizabeth Blackwell, Dr Elizabeth Garrett Anderson, and Dr Emma Constance Stone. We are reaching back into the medical archives.…
Episode 73: Colorectal Cancer (CRC) | Part 3: Management
Patients with colorectal cancer often have their diagnosis, treatment, and care discussed at a regular multidisciplinary team meeting. This includes: gastroenterologists, surgeons, oncology, radiation oncology, pathologists, home care nurses, oncology nurses, genetic councillors, care coordinators …
Episode 72: Colorectal Cancer (CRC) | Part 2: Diagnosis
The lifetime risk for colorectal cancer is 1 in 23 men and 1 in 25 women. Detecting and diagnosing cancer is a critical step in managing a patient’s health as well as the multidisciplinary team where their care is discussed. This is the second episode of a three part series on colorectal cancer. …
Episode 71: Colorectal Cancer (CRC) | Part 1: Screening
Colorectal cancer accounts for ~10% of all new cancer diagnoses. Fortunately, over the last three decades, the 5 year patient survival has increased from 56% to 71%. As with most cancers, the key to good outcomes is early detection. This is the first episode of a three part series on colorectal can…
Episode 70: Understanding Troponin | As Serious As A Heart Attack
Troponin is a protein found in heart muscle that was a game changer when it came to diagnosing heart attacks and myocardial injury in the late 1990s. Three decades later, it is an invaluable test with widespread use throughout medicine. Troponin assays are venturing into their 5th generation with …