Ecal transplant studies are cool because they can show these really quid changes. But we don't need fecal transplants to change the microbiome, you know, getting in nature, eating the right food for medicine, and to use lots of prebodis to help speed that process along too. There's so much we can do that don't the big of a fecal transplant.

Ecal transplant studies are cool because they can show these really quid changes. But we don't need fecal transplants to change the microbiome, you know, getting in nature, eating the right food for medicine, and to use lots of prebodis to help speed that process along too. There's so much we can do that don't the big of a fecal transplant.

Everyone. Before we get into this week's podcast, we got a pretty cool announcement to make you are not able to connect with us. We have a pretty cool little widget that's on the website. Just go to poletailor dot biz Forward Slash Podcast and near the top of the page you'll see a little icon that says send a message to the Pole Tailor podcast. And so what we can do with that You just click on that and then you send us an audio message and we will get the audio message. The first thing I want to do with using it is actually do and ask me anything episode. So all you gotta do if you got a question that we want me to cover is just go to Paul Taylor dot b is z Forward Slash podcast, you know, and start the recording and then send us a message about what you would like me to talk about, and they ask me anything and leave your name. We will call it out on the show. I'll get that all put together. And the other thing you can do is just leave us a message about what you like about the podcast, what you don't like about the podcast, that I talk too much, all of that sort of stuff, and just give us some feedback and we will use that to continuously improve. So looking forward to hearing from you now. I hover the podcast, Jason, horrible act. Hopefully I didn't murder your surname there. Welcome to the podcast.

Everyone. Before we get into this week's podcast, we got a pretty cool announcement to make you are not able to connect with us. We have a pretty cool little widget that's on the website. Just go to poletailor dot biz Forward Slash Podcast and near the top of the page you'll see a little icon that says send a message to the Pole Tailor podcast. And so what we can do with that You just click on that and then you send us an audio message and we will get the audio message. The first thing I want to do with using it is actually do and ask me anything episode. So all you gotta do if you got a question that we want me to cover is just go to Paul Taylor dot b is z Forward Slash podcast, you know, and start the recording and then send us a message about what you would like me to talk about, and they ask me anything and leave your name. We will call it out on the show. I'll get that all put together. And the other thing you can do is just leave us a message about what you like about the podcast, what you don't like about the podcast, that I talk too much, all of that sort of stuff, and just give us some feedback and we will use that to continuously improve. So looking forward to hearing from you now. I hover the podcast, Jason, horrible act. Hopefully I didn't murder your surname there. Welcome to the podcast.

I think you know.

I think you know.

No, it was good, So may we both presented. You wouldn't see me present because you were in Italy and you did a virtual but present at the Acronum conference. And I've seen you bunching around a whole eap of different comforts as your utraine clinicians, mostly around the whole got microbiome. But just give our listeners a sense of your background and how you really got into the microbiome and what you do right now.

No, it was good, So may we both presented. You wouldn't see me present because you were in Italy and you did a virtual but present at the Acronum conference. And I've seen you bunching around a whole eap of different comforts as your utraine clinicians, mostly around the whole got microbiome. But just give our listeners a sense of your background and how you really got into the microbiome and what you do right now.

Yeah, okay, now, thank you. I studied natropathic medicine naturopothy in Australia, Sorted ninety six mission ninety nine and one of the last terms of my four year undergrad course, there was a lectury of my mind when our professors are on dyspouses and how disposus was causing ch chronic disease. This was back in nineteen ninety nine. Is to give some against some context around this, because this has been discussed in the naturopathic struggles for a long time, even though we didn't nessarily have the same science as we do now in the same understanding, but there's a certainly understanding of altered microbiome causing disease. That's been part of natropathic philosophy. For god, there's some writers talking about the early nineteen hundreds again giving some context on that. So it's long been part of naturalathic thinking. It's just that now with the boom and science, we can just see all these different interactions and see what microps are doing, whether we could not see in the past. Anyway, this lecture was totally inspiring to me, so I went up to write after and said, hey, you know, I just went to finish and I was like, can I do my honors agree in this in this area of dys biosis, And then we got together and we did, and we tried to pick a disease that was at that point in time shown to have a dis body element, and that was Irrito boal syndrome. You know, if you look at the diseases that even in the nineties we knew altered microbiome composition were positive or specifically you know, played a key role. In IBS was like the poster child at that point. There's also you know, in flowery biole disease and a couple others, but i'd defy, yeah, that's right. Yeah, that was another option. But we chose IBS because it really was not being handled very well by connition medicine and arty still isn't. And we're like, okay, well let's focus on that. So I did my honors degree looking at how probotics in probodics and herbs would modify the microbiome in patients with IBS, and then we followed up with my PhD after that points. So you know, spending this is now nearly twenty five years since that started. My sort of honors thesis. Literaty Review was back in like probably December of twenty nineteen, sorry, nineteen ninety nine. Delving into the microbiome and how could we could alter the composition of the microbiome with through dietary changes, through prebodics, her medicines, and then also probotics. And since then, you know, I did my PhD in that area, I've been teaching. Now I focus on teaching other clinicians to become what we call, you know, microbiome clinicians or micro literate clinicians, because it's still an area that is barely touched on in the training of conventional health professionals. But even in I would say natural pass like it makes up a much more bigger percentage, but it's still by time when people graduate, they're still lacking a lot of details. I've had to actually implant this in practice, how to interpret stool tests, et cetera, how to make changes based on a microbiome analysis for example, or even people from a dietetic background, nutrition background. It's sa missing that kind of data. So I really trying to upskill Clindians to move into that space and move into us the new understanding of the human body or that microrobes are key elements we can't just ignore like we used to do in the nineteen nineties and before that, you know, you look back at that time and even then called it the microflora back then, but the microflora researchers were like saying, this is important. These microbes are important. We can't just keep ignoring their existence or keep taking a course at antibotics and not thinking it has some long term consequence. But it's just been amazing to see again over the last twenty five years, how that has blown up so dramatically, you know, and that there's many people out there who are now aware of microbiam and it's importance who you know that this is not a talking point besides in small circles, you know, twenty some years ago. So during that time, I still saw patients and I still see patients now because for me, and I've talked to the universities obviously the University of Tasmania for a decade and their evidence based medicine course. Now I teach at University of Western States a natropathic gastroent trology kind of units in their master's degree there, and I have you know, to the research and have I've happened to reasoningly PAHD students working ad too so it's been that to me, that that lovely combination of of academia, education and patients, and I think they feed into eature it really well. Yeah, because when I'm like reading up to prepare for a new lecture, I'm keeping up to day with all the new research that's been done. Then I can try that out of my patients does actually work in the real life or with those with more patients we have to do. Then I can teach that to clinicians like obscure will make get better results with their patients too. So I think it's been a great circle in that way.

Yeah, okay, now, thank you. I studied natropathic medicine naturopothy in Australia, Sorted ninety six mission ninety nine and one of the last terms of my four year undergrad course, there was a lectury of my mind when our professors are on dyspouses and how disposus was causing ch chronic disease. This was back in nineteen ninety nine. Is to give some against some context around this, because this has been discussed in the naturopathic struggles for a long time, even though we didn't nessarily have the same science as we do now in the same understanding, but there's a certainly understanding of altered microbiome causing disease. That's been part of natropathic philosophy. For god, there's some writers talking about the early nineteen hundreds again giving some context on that. So it's long been part of naturalathic thinking. It's just that now with the boom and science, we can just see all these different interactions and see what microps are doing, whether we could not see in the past. Anyway, this lecture was totally inspiring to me, so I went up to write after and said, hey, you know, I just went to finish and I was like, can I do my honors agree in this in this area of dys biosis, And then we got together and we did, and we tried to pick a disease that was at that point in time shown to have a dis body element, and that was Irrito boal syndrome. You know, if you look at the diseases that even in the nineties we knew altered microbiome composition were positive or specifically you know, played a key role. In IBS was like the poster child at that point. There's also you know, in flowery biole disease and a couple others, but i'd defy, yeah, that's right. Yeah, that was another option. But we chose IBS because it really was not being handled very well by connition medicine and arty still isn't. And we're like, okay, well let's focus on that. So I did my honors degree looking at how probotics in probodics and herbs would modify the microbiome in patients with IBS, and then we followed up with my PhD after that points. So you know, spending this is now nearly twenty five years since that started. My sort of honors thesis. Literaty Review was back in like probably December of twenty nineteen, sorry, nineteen ninety nine. Delving into the microbiome and how could we could alter the composition of the microbiome with through dietary changes, through prebodics, her medicines, and then also probotics. And since then, you know, I did my PhD in that area, I've been teaching. Now I focus on teaching other clinicians to become what we call, you know, microbiome clinicians or micro literate clinicians, because it's still an area that is barely touched on in the training of conventional health professionals. But even in I would say natural pass like it makes up a much more bigger percentage, but it's still by time when people graduate, they're still lacking a lot of details. I've had to actually implant this in practice, how to interpret stool tests, et cetera, how to make changes based on a microbiome analysis for example, or even people from a dietetic background, nutrition background. It's sa missing that kind of data. So I really trying to upskill Clindians to move into that space and move into us the new understanding of the human body or that microrobes are key elements we can't just ignore like we used to do in the nineteen nineties and before that, you know, you look back at that time and even then called it the microflora back then, but the microflora researchers were like saying, this is important. These microbes are important. We can't just keep ignoring their existence or keep taking a course at antibotics and not thinking it has some long term consequence. But it's just been amazing to see again over the last twenty five years, how that has blown up so dramatically, you know, and that there's many people out there who are now aware of microbiam and it's importance who you know that this is not a talking point besides in small circles, you know, twenty some years ago. So during that time, I still saw patients and I still see patients now because for me, and I've talked to the universities obviously the University of Tasmania for a decade and their evidence based medicine course. Now I teach at University of Western States a natropathic gastroent trology kind of units in their master's degree there, and I have you know, to the research and have I've happened to reasoningly PAHD students working ad too so it's been that to me, that that lovely combination of of academia, education and patients, and I think they feed into eature it really well. Yeah, because when I'm like reading up to prepare for a new lecture, I'm keeping up to day with all the new research that's been done. Then I can try that out of my patients does actually work in the real life or with those with more patients we have to do. Then I can teach that to clinicians like obscure will make get better results with their patients too. So I think it's been a great circle in that way.

It's interesting because when you look at what the evidences is that new research often takes about a decade or more to get into frontline medicine. Why is there such Have you any idea about why there is such a delay in that.

It's interesting because when you look at what the evidences is that new research often takes about a decade or more to get into frontline medicine. Why is there such Have you any idea about why there is such a delay in that.

Preconceived biases the lack of curiosity amongst many I mean, I would say clinicians like I find this is a sad state, and not honestly in my field, but in other other fields where clicians might be we might be co managing a patient with you know, a all sort of clidius or something, let's say, or a crones of these that have been like not totally non responsive to commission medicines. They work with me, we work on diet and work in microbomb modification, and we get crones of these in remission, and the physician to me would be like, what the hell have you done? We've tried all these drugs for years and nothing's work. You've done something, but that's not been the typical response. It's like, okay, great, move on, and they've got no interest in knowing why. What they've done. Differently, that's created is positive change. And I've seen that quite commonly in the clinical field in terms of taking on the lack of desire to take on new information or keep learning it. And you know, we have having four standards for this and in the health professionals to help ensure that happens to a certain degree. But you can kind of he can choose that as well. And if you have no nutrition interest or no nutrition in microbiome, you're not going to go to any CPE events that train you up in those areas of the sticking your kind of lane. But even in academia, I think it's it can be. I give the example of of you know, I worked at University of test Many for ten years, and you know, my PhD was in you know, area probotics and micro bond molteration, and you know, there was so little of that in this sort of pharmacy course there. Like I had my own sort of you know, Evans based company medicine program, which was a post grad course that we had a different kind of student base. But for me, it was like I just felt like a very underutilized resource that I should be. You're expounding the wonders of microboond science to the generation every generation pharmacy students, and then how we should use in provoducts and practice and the evidence basic providucts, et cetera. But you know, we only had a couple of hours per for your student to actually get there any of that information in, you know, And I think that that's not on call.

Preconceived biases the lack of curiosity amongst many I mean, I would say clinicians like I find this is a sad state, and not honestly in my field, but in other other fields where clicians might be we might be co managing a patient with you know, a all sort of clidius or something, let's say, or a crones of these that have been like not totally non responsive to commission medicines. They work with me, we work on diet and work in microbomb modification, and we get crones of these in remission, and the physician to me would be like, what the hell have you done? We've tried all these drugs for years and nothing's work. You've done something, but that's not been the typical response. It's like, okay, great, move on, and they've got no interest in knowing why. What they've done. Differently, that's created is positive change. And I've seen that quite commonly in the clinical field in terms of taking on the lack of desire to take on new information or keep learning it. And you know, we have having four standards for this and in the health professionals to help ensure that happens to a certain degree. But you can kind of he can choose that as well. And if you have no nutrition interest or no nutrition in microbiome, you're not going to go to any CPE events that train you up in those areas of the sticking your kind of lane. But even in academia, I think it's it can be. I give the example of of you know, I worked at University of test Many for ten years, and you know, my PhD was in you know, area probotics and micro bond molteration, and you know, there was so little of that in this sort of pharmacy course there. Like I had my own sort of you know, Evans based company medicine program, which was a post grad course that we had a different kind of student base. But for me, it was like I just felt like a very underutilized resource that I should be. You're expounding the wonders of microboond science to the generation every generation pharmacy students, and then how we should use in provoducts and practice and the evidence basic providucts, et cetera. But you know, we only had a couple of hours per for your student to actually get there any of that information in, you know, And I think that that's not on call.

That they comes to the miniature issue, isn't it. And I mean there's a certain amount I find as a bystander who it goes to lots of different conferences. I talk at conferences there is a bit of a looking down the nose from traditional medicine at naturopathic medicine. Yeah, and thinking it's woo woo stuff. But there is, as you taught and evidence being complementary medicine course at a university right And for me, it's like, if you've got anything that is originating in the gut and will explore the huge amount of diseases and both physical and mental that have origins or at least contributing factors from the gut, why would you go to a GP who gets no nutritional training or maybe two weeks at best, and gets no training on the microbiome whatsoever. And you know, are not incentivized to do ongoing learning for this. I mean there are a bunch of doctors who do the ones who are at the active conference. You know, there's a whole bunch of bunch of doctors there when we be there. But your traditional GP or the traditional medical system is really not well equipped for diseases that have a gastro intestinal origin, of which we are seeing more and more right now. I think my eyes got opened to this area a big time. It would have been a decade or maybe a little bit more ago I saw Professor Thomas Barrodi. You will be very aware of runs the Center for Digestive Diseases in Sydney.

That they comes to the miniature issue, isn't it. And I mean there's a certain amount I find as a bystander who it goes to lots of different conferences. I talk at conferences there is a bit of a looking down the nose from traditional medicine at naturopathic medicine. Yeah, and thinking it's woo woo stuff. But there is, as you taught and evidence being complementary medicine course at a university right And for me, it's like, if you've got anything that is originating in the gut and will explore the huge amount of diseases and both physical and mental that have origins or at least contributing factors from the gut, why would you go to a GP who gets no nutritional training or maybe two weeks at best, and gets no training on the microbiome whatsoever. And you know, are not incentivized to do ongoing learning for this. I mean there are a bunch of doctors who do the ones who are at the active conference. You know, there's a whole bunch of bunch of doctors there when we be there. But your traditional GP or the traditional medical system is really not well equipped for diseases that have a gastro intestinal origin, of which we are seeing more and more right now. I think my eyes got opened to this area a big time. It would have been a decade or maybe a little bit more ago I saw Professor Thomas Barrodi. You will be very aware of runs the Center for Digestive Diseases in Sydney.

Yeah, and like the world trendsetter in fecal transplant.

Yeah, and like the world trendsetter in fecal transplant.

Yeah. So so just tell our listeners actually that you can tell that story about what the kind of early facal trend plant stuff was showing for things like ceed of facil and other stuff. Just give our listeners a bit of a sense of that.

Yeah. So so just tell our listeners actually that you can tell that story about what the kind of early facal trend plant stuff was showing for things like ceed of facil and other stuff. Just give our listeners a bit of a sense of that.

Yeah, I mean not my probably our take on that would be obviously nowhere near as detailed to some like like doctor Bordie, who's like the driver of that. But I do think that you know, we have a condition that seed of ficil or clusterdy or use the facility superfection that happens not uncommonly after a course of antibotics. Some antobotics have higher risk not uncommonly after going into the hospital settings, because it turns out that cediff wares everywhere throughout hospitals, and that people are given anobotics often in hospital and that combination is particularly bad and because of the fact that antabotics are the driver of the condition. Essentially, antabotics that cause massive microbiome disruption allow the seedf to actually grow and thrive in the environment. Then people can get immensely unwealth from you know, modely moderate symptoms like you know, diarrhea and discomforts are actually dying. It can be very severe infection, and its success rate with treating with more antibiotics is not great.

Yeah, I mean not my probably our take on that would be obviously nowhere near as detailed to some like like doctor Bordie, who's like the driver of that. But I do think that you know, we have a condition that seed of ficil or clusterdy or use the facility superfection that happens not uncommonly after a course of antibotics. Some antobotics have higher risk not uncommonly after going into the hospital settings, because it turns out that cediff wares everywhere throughout hospitals, and that people are given anobotics often in hospital and that combination is particularly bad and because of the fact that antabotics are the driver of the condition. Essentially, antabotics that cause massive microbiome disruption allow the seedf to actually grow and thrive in the environment. Then people can get immensely unwealth from you know, modely moderate symptoms like you know, diarrhea and discomforts are actually dying. It can be very severe infection, and its success rate with treating with more antibiotics is not great.

Because like you know, that was very kind of you, jes what he said. Not great. It's pretty pathetic.

Because like you know, that was very kind of you, jes what he said. Not great. It's pretty pathetic.

Really.

Really.

The conventional medical treatment of seed def is pesper Yeah.

The conventional medical treatment of seed def is pesper Yeah.

And then then they're like, Okay, well maybe it's a it's a despotic state. Maybe we need to encourage that ecosystem back to a healthier state. And the quickest way of doing that, I mean, there has been some research on probotics, which is you know, where you're giving one or two or three different types of bactory and the research and CF is hidden is depending on the combination. But again that's that's a really really small thing. Given that the typically ecsystem have one hundred and sixty different species of bacteria and you just add some lackt of cilizen there. It's like not a huge restoration approach versus FMT where you're taking pooh from a healthy person and you're adding one hundred and fifty or two hundred species into that ecosystem. So it helps restore that the ecoism essentially would be the way best way of looking at it. And you're getting phenomenal success rates with c DIFF and so much like you you wonder whine or if that isn't first sort of call by at the convention medicine whenever anyone has see if that FMT should be the first portocole, it's not even now they will still do a couple of course antibotics first. Then then maybe it might be third down the line in most sort of guidelines. But when you give f MT, which I think is ludicrous given the success rate and low risk of toxic side effects with FMT, assuming of course that we've screened the donors well. And I think they're having lessons learned in this because there were cases where people become obese after fecal transplant when the donor was no beast person, or people could get depressed or anxious after a fecal transplant because the donor happened to have depression. You know, we've learned from some of those experiences about what things we shot looking at. Besides just they don't have arrange of diseases. It's just like they can't be overweight. They've got to be medically well, they've got to have good mood. There's other criteria to look at to find you know, I would I say good donors, so there's less risk of any unwanted sort of disease pass on, because I think that's the amazing thing that's changed in the last twenty years. Is this you kind of alluded to, is the number of diseases we now associate with despotic or negative alterations in the microbion composition, even things like hypertension. Like I would not have thought, even someone who spent years admiring in wonder of the microbiome, thinking that that hypertension was a disease of dyspiosis. But we can take pooh transplants from people who have low blood pressure normal blood pressure, and given to people high blood pssure and their blood pressure will normalize.

And then then they're like, Okay, well maybe it's a it's a despotic state. Maybe we need to encourage that ecosystem back to a healthier state. And the quickest way of doing that, I mean, there has been some research on probotics, which is you know, where you're giving one or two or three different types of bactory and the research and CF is hidden is depending on the combination. But again that's that's a really really small thing. Given that the typically ecsystem have one hundred and sixty different species of bacteria and you just add some lackt of cilizen there. It's like not a huge restoration approach versus FMT where you're taking pooh from a healthy person and you're adding one hundred and fifty or two hundred species into that ecosystem. So it helps restore that the ecoism essentially would be the way best way of looking at it. And you're getting phenomenal success rates with c DIFF and so much like you you wonder whine or if that isn't first sort of call by at the convention medicine whenever anyone has see if that FMT should be the first portocole, it's not even now they will still do a couple of course antibotics first. Then then maybe it might be third down the line in most sort of guidelines. But when you give f MT, which I think is ludicrous given the success rate and low risk of toxic side effects with FMT, assuming of course that we've screened the donors well. And I think they're having lessons learned in this because there were cases where people become obese after fecal transplant when the donor was no beast person, or people could get depressed or anxious after a fecal transplant because the donor happened to have depression. You know, we've learned from some of those experiences about what things we shot looking at. Besides just they don't have arrange of diseases. It's just like they can't be overweight. They've got to be medically well, they've got to have good mood. There's other criteria to look at to find you know, I would I say good donors, so there's less risk of any unwanted sort of disease pass on, because I think that's the amazing thing that's changed in the last twenty years. Is this you kind of alluded to, is the number of diseases we now associate with despotic or negative alterations in the microbion composition, even things like hypertension. Like I would not have thought, even someone who spent years admiring in wonder of the microbiome, thinking that that hypertension was a disease of dyspiosis. But we can take pooh transplants from people who have low blood pressure normal blood pressure, and given to people high blood pssure and their blood pressure will normalize.

You holy shit, excuse the pod exactly. So I just need to double click here for some people who might be going FMT fecal transplants, just just to clarify for some people who may not be familiar with it. This is what you get, as you said, a healthy donor and you get some of their pooh, and then it goes into a big syringe and goes up their JAXI.

You holy shit, excuse the pod exactly. So I just need to double click here for some people who might be going FMT fecal transplants, just just to clarify for some people who may not be familiar with it. This is what you get, as you said, a healthy donor and you get some of their pooh, and then it goes into a big syringe and goes up their JAXI.

Typically, yeah, it doesn't even a form too, but yes.

Typically, yeah, it doesn't even a form too, but yes.

It's a medical to Oh yeah, crapsules they're now being called yeah. Yeah. And and basically what happens is is that donors microbiome repopulates the colon of the unhealthy person. But as you said, I didn't know we've actually seen that in humans, right, because years ago I remember reading this stuff that from animal studies, you could take a perfectly healthy mouse and given a fecal transplant of a mouse with depression or anxiety, or obesity or diabetes, and within a couple of weeks, with no change in the environment, that mouse would develop those conditions, and then they could reverse it as well. So now you're saying that it in humans with people getting depression or obesity from unscreened donors, right, this is that this is that do not do at home people for those reasons, Yeah, and lots of other reasons. Right. Yeah.

It's a medical to Oh yeah, crapsules they're now being called yeah. Yeah. And and basically what happens is is that donors microbiome repopulates the colon of the unhealthy person. But as you said, I didn't know we've actually seen that in humans, right, because years ago I remember reading this stuff that from animal studies, you could take a perfectly healthy mouse and given a fecal transplant of a mouse with depression or anxiety, or obesity or diabetes, and within a couple of weeks, with no change in the environment, that mouse would develop those conditions, and then they could reverse it as well. So now you're saying that it in humans with people getting depression or obesity from unscreened donors, right, this is that this is that do not do at home people for those reasons, Yeah, and lots of other reasons. Right. Yeah.

But it's been it's been interesting because I think you go back to I think it was two thousand and end of Taison five that first paper was published where they gave poo from obese mice to thin mice, and those mice got obese despite no change in cloric intake or or or output. You know, they weren't exercising it any less. They were eating the same out of food and it just became grossly obese just from a pood transplant. That was a game changer in them, and not say broader understanding of I've got and the importance of the of the gut medical access, but but also that that how important got microphone is in that because before that we were like, yeah they got microphone matters and IBS or in family ball disease, like these gut conditions, but maybe not outside that. But that blew it open, going, oh my god, you know if we can pass on obesity by doing pood transplants. That opened the door to yeah, now there's research looking at depression, anxiety, hypertension. If I mentioned before diabetes, so many things we can thease that we would have not thought of as like transmitsible. We can transmit via even Alzheimer's, you know, we can. We can take you poo from adults with Alzheimer's and give it to routes and they develop it into Alzheimer's disease.

But it's been it's been interesting because I think you go back to I think it was two thousand and end of Taison five that first paper was published where they gave poo from obese mice to thin mice, and those mice got obese despite no change in cloric intake or or or output. You know, they weren't exercising it any less. They were eating the same out of food and it just became grossly obese just from a pood transplant. That was a game changer in them, and not say broader understanding of I've got and the importance of the of the gut medical access, but but also that that how important got microphone is in that because before that we were like, yeah they got microphone matters and IBS or in family ball disease, like these gut conditions, but maybe not outside that. But that blew it open, going, oh my god, you know if we can pass on obesity by doing pood transplants. That opened the door to yeah, now there's research looking at depression, anxiety, hypertension. If I mentioned before diabetes, so many things we can thease that we would have not thought of as like transmitsible. We can transmit via even Alzheimer's, you know, we can. We can take you poo from adults with Alzheimer's and give it to routes and they develop it into Alzheimer's disease.

It's great, is that right?

It's great, is that right?

Yeah?

Yeah?

Wow? So I've seen some stuff obviously about Parkinson's disease. There's a there's quite a strong theory that it starts in the gout NYE. But that Alzheimer's one is Wow, that is interesting and it just opens up a whole world. So that I think that's a really good segue into the got Brian microbio too. Access. So just give people a bit of an overview of the current state of play, Like, Hi, how is the communication happening between the got the brain and the and the microbiome, you know, this whole idea of the second brain. Just just give give people a two or three minute overview of what we currently know.

Wow? So I've seen some stuff obviously about Parkinson's disease. There's a there's quite a strong theory that it starts in the gout NYE. But that Alzheimer's one is Wow, that is interesting and it just opens up a whole world. So that I think that's a really good segue into the got Brian microbio too. Access. So just give people a bit of an overview of the current state of play, Like, Hi, how is the communication happening between the got the brain and the and the microbiome, you know, this whole idea of the second brain. Just just give give people a two or three minute overview of what we currently know.

Okay, I don't even take it further step back into scope like the gut microbiome, Yeah, totally, But it's essentially generally, when we see the gut microbiome, we're talking about the microbes growing in the colon. You know, we will have a different microbulag because it's in a small testine and far less diverse in the stomach, for example. But when we say microbiome, we're generally talking about colonic ecosism. Are large intestine, but one hundred trillion different micro one hundred trillion microbes living in that environment. And there's some debate about, you know, whether there are ten times a number of microbes in our guts there was human cells. It's two times or three times, but either way we have there's you know, considered amount of us is actually composed of a microbe. And I think that's the other chain in thinking from just sort of segue to you know, again going back twenty some years ago, these researchers who looking at the microfloor at the time were like, you know, we should we need to look at this as an additional human organ just as important as the liver or the small testine to human health. And I think that shifting it. That's finally taken on board in many circles, but it's even moved beyond that to actually we are a whole of violence, which is the term just meaning that we are composed of microbes and non microbe cells, yeah, and all both, all of which is important. So when we kind of take that on board, we have you know, one hundred trillion cells in our gut that actually influence every single system of our body is influenced by that ecosystem in our gut. That's what we're We've found out now how immune system works, how metabal system work, metabolism works, how your brain works. You know, all that is related to how your mitochondria working. Are related to that that that ecosystem in our gut. And typically we have for Westerners, but one hundred and sixty different species present in your gut. But that's far far less, and then we we're traditionally had and far less what we see in hundred gathered societies or yeah, that's right, you know, even like I do microbomb assessments with I have for many years to the thousands of patients now and you know, the lowest I've seen on a microbod assessment was twelve species and someone who is on bank of mice and all of them were pathogenic.

Okay, I don't even take it further step back into scope like the gut microbiome, Yeah, totally, But it's essentially generally, when we see the gut microbiome, we're talking about the microbes growing in the colon. You know, we will have a different microbulag because it's in a small testine and far less diverse in the stomach, for example. But when we say microbiome, we're generally talking about colonic ecosism. Are large intestine, but one hundred trillion different micro one hundred trillion microbes living in that environment. And there's some debate about, you know, whether there are ten times a number of microbes in our guts there was human cells. It's two times or three times, but either way we have there's you know, considered amount of us is actually composed of a microbe. And I think that's the other chain in thinking from just sort of segue to you know, again going back twenty some years ago, these researchers who looking at the microfloor at the time were like, you know, we should we need to look at this as an additional human organ just as important as the liver or the small testine to human health. And I think that shifting it. That's finally taken on board in many circles, but it's even moved beyond that to actually we are a whole of violence, which is the term just meaning that we are composed of microbes and non microbe cells, yeah, and all both, all of which is important. So when we kind of take that on board, we have you know, one hundred trillion cells in our gut that actually influence every single system of our body is influenced by that ecosystem in our gut. That's what we're We've found out now how immune system works, how metabal system work, metabolism works, how your brain works. You know, all that is related to how your mitochondria working. Are related to that that that ecosystem in our gut. And typically we have for Westerners, but one hundred and sixty different species present in your gut. But that's far far less, and then we we're traditionally had and far less what we see in hundred gathered societies or yeah, that's right, you know, even like I do microbomb assessments with I have for many years to the thousands of patients now and you know, the lowest I've seen on a microbod assessment was twelve species and someone who is on bank of mice and all of them were pathogenic.

Into it's likely twelve space twelve series.

Into it's likely twelve space twelve series.

Yeah, and they're all bad. You know, there's not a good one to be seen. And conversely, I've seen four hundred and thirty genera, so so we didn't go to speedees of a general level. Was just that was that was someone who grew up in rural Mexico and no antabotics. They were you know, born bonn at home and you know they were breastfit. You know, it's just like that's the contrasting things that I've seen in my clical practice. But a lot of you know, things that we get exposed to in Western nations have caused a massive reduction in diversity. Every egoism so that that is anabotics, that is proton pump behaviors, and the class medications we use to treat reflux turn out to be quite potent antibotic like agents too. You know, I think twenty percent of microbes and then gat are sensitive to are damaged by protram pumpmavers. So we see massive loss of diversity, and these medications are given like candy to you know, even in Australia's like in ten million scripts or something for pbiser, you know, per year, and we only have twenty five six million people. You know, we get some context on that. Then we Western diet and we have the craft that's in our diet too, like a multifiers, I feel, sweeteners, all these things kill our peditial bacteria and damage the ecosystem.

Yeah, and they're all bad. You know, there's not a good one to be seen. And conversely, I've seen four hundred and thirty genera, so so we didn't go to speedees of a general level. Was just that was that was someone who grew up in rural Mexico and no antabotics. They were you know, born bonn at home and you know they were breastfit. You know, it's just like that's the contrasting things that I've seen in my clical practice. But a lot of you know, things that we get exposed to in Western nations have caused a massive reduction in diversity. Every egoism so that that is anabotics, that is proton pump behaviors, and the class medications we use to treat reflux turn out to be quite potent antibotic like agents too. You know, I think twenty percent of microbes and then gat are sensitive to are damaged by protram pumpmavers. So we see massive loss of diversity, and these medications are given like candy to you know, even in Australia's like in ten million scripts or something for pbiser, you know, per year, and we only have twenty five six million people. You know, we get some context on that. Then we Western diet and we have the craft that's in our diet too, like a multifiers, I feel, sweeteners, all these things kill our peditial bacteria and damage the ecosystem.

I think, just on that to jump in there, there was an Umbrella review published quite recently around ultra processed foods and showing that increasing consumption, they had class one evidence of a fifty percent increased risk in cardiovascular deaths, forty eight percent increased risk of anxiety, and fifty three percent increase risk of common mental health disorder. Like, this is the kneil in the coffin of ultra processed foods, right, this shit should be banned.

I think, just on that to jump in there, there was an Umbrella review published quite recently around ultra processed foods and showing that increasing consumption, they had class one evidence of a fifty percent increased risk in cardiovascular deaths, forty eight percent increased risk of anxiety, and fifty three percent increase risk of common mental health disorder. Like, this is the kneil in the coffin of ultra processed foods, right, this shit should be banned.

Yeah, I know, and you dig into You're like, wo, how are we allowed to be selling this stuff? Why are we allowed to excessus? Because I mean our health problems. You know, you and ore old enough to have seen this huge increase in Alzheimer's and typy diabetes and obesily like you take put photos and beaches in the sixties and seventies, they don't not have the same as first time.

Yeah, I know, and you dig into You're like, wo, how are we allowed to be selling this stuff? Why are we allowed to excessus? Because I mean our health problems. You know, you and ore old enough to have seen this huge increase in Alzheimer's and typy diabetes and obesily like you take put photos and beaches in the sixties and seventies, they don't not have the same as first time.

Now now it's like a different species ash And just on that point, in the next couple of years, they reckon that dementia is going to be the biggest killer of all Australians right just now number two. It's number two, and it's the biggest killer of females currently.

Now now it's like a different species ash And just on that point, in the next couple of years, they reckon that dementia is going to be the biggest killer of all Australians right just now number two. It's number two, and it's the biggest killer of females currently.

Yeah, and going back in the ultra process food like, I was reading some research showing that in America, some seven percent of their dietaries supply for some people is ultra process seventy percent. You know, in Australia we're better off, but sheese, you know, not dramatically better off. If you look at what people put in their shopping trolleys of the save market, Like, my god, so many people are choosing those feelings.

Yeah, and going back in the ultra process food like, I was reading some research showing that in America, some seven percent of their dietaries supply for some people is ultra process seventy percent. You know, in Australia we're better off, but sheese, you know, not dramatically better off. If you look at what people put in their shopping trolleys of the save market, Like, my god, so many people are choosing those feelings.

We are in the top six countries of global ultra process food sales, so I think we're not that far And you're right at both the UK and in the United States, especially teenagers, almost seventy percent of their diet process foods. And when we think about what that does to the microbiome. So you talked about multifiers having an issue, but it's also preservatives and flavor enhancers and things like that, right that just do we know how these things impact the microbiome ni But.

We are in the top six countries of global ultra process food sales, so I think we're not that far And you're right at both the UK and in the United States, especially teenagers, almost seventy percent of their diet process foods. And when we think about what that does to the microbiome. So you talked about multifiers having an issue, but it's also preservatives and flavor enhancers and things like that, right that just do we know how these things impact the microbiome ni But.

We're teasing into some of the stuff at now, and even I would argue agricultural chemicals too. I think, like common things like life is safe, but others, you know, and those forever chemicals kill good bactery as well. It's like, all of a sudden, we're living in this toxic soup where almost everything people are eating intends to be killing finial bacteria. It's kind of the state that many Westerners are in. There's been a lot more research delving into a multifier since twenty fourteen. I think the first paper was done looking at that because you know, people had not thought of it before then in terms of like, oh, look, it kind of strips away your protective gut lining. You can induce type two diabetes and metabolic syndrome in animal models is by giving them dietary mulsifiers at the high end of what humans could consume on a multiprocessed diet, you know, and you're like, okay, look at that, and it changes the microbiome. We get reductions of beneficial bactery and we get these blooms of proteobacteria, typically in protebacteria as you know, a phylum of bactery and the gat. All of us will have some there, but it varies dramatically how much is there, and one of the attributes are all putting back to his shares. They contain this very pro inflammatory a bit of the cell wall called endotoxin or lipopolysaccharide LPs for short. Yeah, so when we eat these foods, LPs levels go up, and it's just terms that the LPs. Just to be clear here, they just grow it. Like you know we grow hair, we grow nails, they grow LPs. You know, they're not trying to make us unwell by screating a toxin in this instance, They're just growing the stuff. So when they live, they're constantly shedding it. When they die, they shed it. So the more proto vector we have in our gut, the more endotoxin or LPs we have in our gut. And you know, we have got some detox maktives to deal with some of that, but you know, we've got so much more getting into our system now that the LPs, I think is really one of the causative ways of which the microbiome alters. I would say everything in a negative way. You know, we know that that that LPs actually damages the blood brain barrier, causing their logical inflammation. Interesting research in Alzheimer's patients where people of Alzheimer's they have three times more LPs in their bloodstreams than an age match healthy controls. They have between three and twenty six more times in their brain on autopsy than compared to healthy control bodies. Autopsies it's just like it's crazy. And where where that is the the plaques build up around the.

We're teasing into some of the stuff at now, and even I would argue agricultural chemicals too. I think, like common things like life is safe, but others, you know, and those forever chemicals kill good bactery as well. It's like, all of a sudden, we're living in this toxic soup where almost everything people are eating intends to be killing finial bacteria. It's kind of the state that many Westerners are in. There's been a lot more research delving into a multifier since twenty fourteen. I think the first paper was done looking at that because you know, people had not thought of it before then in terms of like, oh, look, it kind of strips away your protective gut lining. You can induce type two diabetes and metabolic syndrome in animal models is by giving them dietary mulsifiers at the high end of what humans could consume on a multiprocessed diet, you know, and you're like, okay, look at that, and it changes the microbiome. We get reductions of beneficial bactery and we get these blooms of proteobacteria, typically in protebacteria as you know, a phylum of bactery and the gat. All of us will have some there, but it varies dramatically how much is there, and one of the attributes are all putting back to his shares. They contain this very pro inflammatory a bit of the cell wall called endotoxin or lipopolysaccharide LPs for short. Yeah, so when we eat these foods, LPs levels go up, and it's just terms that the LPs. Just to be clear here, they just grow it. Like you know we grow hair, we grow nails, they grow LPs. You know, they're not trying to make us unwell by screating a toxin in this instance, They're just growing the stuff. So when they live, they're constantly shedding it. When they die, they shed it. So the more proto vector we have in our gut, the more endotoxin or LPs we have in our gut. And you know, we have got some detox maktives to deal with some of that, but you know, we've got so much more getting into our system now that the LPs, I think is really one of the causative ways of which the microbiome alters. I would say everything in a negative way. You know, we know that that that LPs actually damages the blood brain barrier, causing their logical inflammation. Interesting research in Alzheimer's patients where people of Alzheimer's they have three times more LPs in their bloodstreams than an age match healthy controls. They have between three and twenty six more times in their brain on autopsy than compared to healthy control bodies. Autopsies it's just like it's crazy. And where where that is the the plaques build up around the.

The amyloid plaques. Yeah, yeah, because it's a it's because it's a it's a it's a foreign in theater, right, So the amyloid plaque is lied laid down to protect against damages. Yeah.

The amyloid plaques. Yeah, yeah, because it's a it's because it's a it's a it's a foreign in theater, right, So the amyloid plaque is lied laid down to protect against damages. Yeah.

And it's this LPs that's coming from the gut that's actually driving this.

And it's this LPs that's coming from the gut that's actually driving this.

Yeah, so this is why and the mechanism chased. Sorry, so the LPs did you say did I hear you say that it basically degrades the mucous membrane. It does?

Yeah, so this is why and the mechanism chased. Sorry, so the LPs did you say did I hear you say that it basically degrades the mucous membrane. It does?

You know, we call say he got to enhance permie belief. So it definitely causes that. It drives information body wide, Okay, but we also know that it actually kept directly damages the blood brain barrier. It causes you know, neurological information. It changes our nerves neurotransmitters too. You know those studies where they've given happy, healthy people a shot of endotoxin and they get anxious and depressed for hours afterwards, you know, before birth clears it out. And we know that actually is able to get into the brain and actually change what neuro transfer that reproduce. You know, we get less you know, serotonin happy happy compounds when we have more DX in our system. They've done brain scans of people have to give them a shot of endotox in their brains turned bright red everywhere. But we live in a reading this dietary approach for many Westerners who just have this LPs leaking into their bloodstream twenty four hours a day, seven days a week. That's driving the chronic disease is that we see from obesity to typew diabetes to Alzheimer's. You know these are all LPs driven conditions. Yeah, I would anxiety depression of me two for that matter.

You know, we call say he got to enhance permie belief. So it definitely causes that. It drives information body wide, Okay, but we also know that it actually kept directly damages the blood brain barrier. It causes you know, neurological information. It changes our nerves neurotransmitters too. You know those studies where they've given happy, healthy people a shot of endotoxin and they get anxious and depressed for hours afterwards, you know, before birth clears it out. And we know that actually is able to get into the brain and actually change what neuro transfer that reproduce. You know, we get less you know, serotonin happy happy compounds when we have more DX in our system. They've done brain scans of people have to give them a shot of endotox in their brains turned bright red everywhere. But we live in a reading this dietary approach for many Westerners who just have this LPs leaking into their bloodstream twenty four hours a day, seven days a week. That's driving the chronic disease is that we see from obesity to typew diabetes to Alzheimer's. You know these are all LPs driven conditions. Yeah, I would anxiety depression of me two for that matter.

Let's talk about the mechanisms here, because I really want people to understand the structure of the colon and why mucous membrane is so important. I mean, most people are shocked when I tell them that at least eighty percent of the immune system resides in the gut. So talk us through what actually is happening when this mucus man Brian is being degree of it. Then the implications of that, like what we know happens with a leaky gut.

Let's talk about the mechanisms here, because I really want people to understand the structure of the colon and why mucous membrane is so important. I mean, most people are shocked when I tell them that at least eighty percent of the immune system resides in the gut. So talk us through what actually is happening when this mucus man Brian is being degree of it. Then the implications of that, like what we know happens with a leaky gut.

Yeah, and we see this as a very essentially the consequence of a Western diet. The Western diet, you know, contains these chemicals which actually strip away your protective mucus layer, but also don't feed your your bendach bacteria that are protective and help protect your umucosa as well. So we have this double whammy that's going on. So essentially we're getting this penetration of bacteri and bacterial byproducts that wouldn't normally get through there's normally a thick mucus layer, and even if they're there, they just can't contact the cells themselves. But when we thin out that mucus layer, were enable that contact between bacteria and their LPs to actually directly cause information and that causes leakiness. Then that LPs gets in the bloodstream, and we do have metaoves to try to deal with that. Like our liver is quite adapted dealing with LPs for a certain period of time at a certain amount. It's just that when it becomes overwhelmed, then it reaches the body wide circulation and that's where it starts causing havoc everywhere. And this is where we see, like you know, alcoholic liver disease is like it's the endotoxins that are causing liver damage. Yeah, it's just the alcohol causes the leak.

Yeah, and we see this as a very essentially the consequence of a Western diet. The Western diet, you know, contains these chemicals which actually strip away your protective mucus layer, but also don't feed your your bendach bacteria that are protective and help protect your umucosa as well. So we have this double whammy that's going on. So essentially we're getting this penetration of bacteri and bacterial byproducts that wouldn't normally get through there's normally a thick mucus layer, and even if they're there, they just can't contact the cells themselves. But when we thin out that mucus layer, were enable that contact between bacteria and their LPs to actually directly cause information and that causes leakiness. Then that LPs gets in the bloodstream, and we do have metaoves to try to deal with that. Like our liver is quite adapted dealing with LPs for a certain period of time at a certain amount. It's just that when it becomes overwhelmed, then it reaches the body wide circulation and that's where it starts causing havoc everywhere. And this is where we see, like you know, alcoholic liver disease is like it's the endotoxins that are causing liver damage. Yeah, it's just the alcohol causes the leak.

He got.

He got.

Alcohol causes you know, damage in the cos allows the enderdosin through. Alcohol causes blooms of protibacteria in the gad. Yeah, and that allows the endotoxin to come through and cause damage to liver. And even in what we're called non alcohol I fat liver disease. It's not got a recently updated name, but it's that is damage is driven by endotoxins as well.

Alcohol causes you know, damage in the cos allows the enderdosin through. Alcohol causes blooms of protibacteria in the gad. Yeah, and that allows the endotoxin to come through and cause damage to liver. And even in what we're called non alcohol I fat liver disease. It's not got a recently updated name, but it's that is damage is driven by endotoxins as well.

Primarily interesting that alcohol causes a leaky God, I did not know that. And this is this is a very verging on oversharing right here, because I had some bol issues a few years ago and was a little bit concerned about just how diarrhea in the mornings not all the time. But I went and I ended up having a colonic, not a colonic. I ended up having a end endoscopy yet and it was all clear. And then what I worked out is it was after I drunk alcohol, and that now it makes perfect sense, So I I just sort of worked it, Jesus, it's after I drank the night the next morning, That's the only time that I have that diary yet and now it makes sense.

Primarily interesting that alcohol causes a leaky God, I did not know that. And this is this is a very verging on oversharing right here, because I had some bol issues a few years ago and was a little bit concerned about just how diarrhea in the mornings not all the time. But I went and I ended up having a colonic, not a colonic. I ended up having a end endoscopy yet and it was all clear. And then what I worked out is it was after I drunk alcohol, and that now it makes perfect sense, So I I just sort of worked it, Jesus, it's after I drank the night the next morning, That's the only time that I have that diary yet and now it makes sense.

Yeah, and I think even like the hangover effect, I think is because of the anterotoxin that's to the intertoxins that that come into your brain, your brain from that alcohol ingestion too. Yeah wow Yeah. And alcohol also slows down your small vowel transit to so you get this sort of extra effective, if extra capacity to absorb stuff through that that damage small vowel too, because microbes aren't moving things aren't moving through in the same way. Cause I trade a lot of patients with overgrowth the bactory and the small intestine SIBO small intestin vactory over with alcohol that come and reinduce her some of the clear cebo it's gone, But then it might be you know, Christmas and your time, and they end up drinking apes and seb overturn as a consequence of that alcohol ingest interesting stops.

Yeah, and I think even like the hangover effect, I think is because of the anterotoxin that's to the intertoxins that that come into your brain, your brain from that alcohol ingestion too. Yeah wow Yeah. And alcohol also slows down your small vowel transit to so you get this sort of extra effective, if extra capacity to absorb stuff through that that damage small vowel too, because microbes aren't moving things aren't moving through in the same way. Cause I trade a lot of patients with overgrowth the bactory and the small intestine SIBO small intestin vactory over with alcohol that come and reinduce her some of the clear cebo it's gone, But then it might be you know, Christmas and your time, and they end up drinking apes and seb overturn as a consequence of that alcohol ingest interesting stops.

So you got alcohol, You got alcohol, significant alcohol, all to a typical SAD diet, the standard American or the standard Australian diet towards standard it's the standard Western diet, but the standard Western diet on its own a shithouse for your microbiome. Just a recap for people, it basically encourages his LPs, which degrade your mucous membrane. And I also if you're not having a lot of fiber. My understanding is the fiber munching bacteria in your gut that thrive off fiber, they turn into cannibals when you don't have enough fiber and to eat your mucus membry and so we have then a double wami from that. Plus you're not supporting your healthy microbiome, then you get an unhealthy one. You get leaky gut, then you get LPs getting into the bloodstream triggers and immune response and then gets into the brain. And what other impacts does that have metabolically? I think you mentioned the mitochondria earlier.

So you got alcohol, You got alcohol, significant alcohol, all to a typical SAD diet, the standard American or the standard Australian diet towards standard it's the standard Western diet, but the standard Western diet on its own a shithouse for your microbiome. Just a recap for people, it basically encourages his LPs, which degrade your mucous membrane. And I also if you're not having a lot of fiber. My understanding is the fiber munching bacteria in your gut that thrive off fiber, they turn into cannibals when you don't have enough fiber and to eat your mucus membry and so we have then a double wami from that. Plus you're not supporting your healthy microbiome, then you get an unhealthy one. You get leaky gut, then you get LPs getting into the bloodstream triggers and immune response and then gets into the brain. And what other impacts does that have metabolically? I think you mentioned the mitochondria earlier.

On Yeah, because LPs is also mitochondria toxin. Wow. To add add to the mix of everything else that's actually doing it did impairs insolent sensitivity too, so it drives you know, likely good levels to go up to by impairing your insulin capacity to bring levels down. It's it's a really horrific substance where you look at it and you're like, oh my god, I do not want this stuff in my blood stream. Would you eat the best die possible to prevent that LPs load getting into my gut into reduced levels of LPs vector and you got because it really is, Yeah, I think it. You know, it's seems a very core driver of Alzheimer's and not it's funny. Look at the research, it's all very clear out there. But then like the sude people who you know, Alzheimer's specialists who just still have no idea of any of the stuff around got that we good in other areas, but completely ignorant of things like that, which I still find problematic. Means the end result of people aren't getting proper care and we're ignoring a core underlying driver that that that needs to be addressed if we wanted to to prevent this sort of Alzheimer's and the gemmick that we're seeing. And it's so the only they can be getting worse too that.

On Yeah, because LPs is also mitochondria toxin. Wow. To add add to the mix of everything else that's actually doing it did impairs insolent sensitivity too, so it drives you know, likely good levels to go up to by impairing your insulin capacity to bring levels down. It's it's a really horrific substance where you look at it and you're like, oh my god, I do not want this stuff in my blood stream. Would you eat the best die possible to prevent that LPs load getting into my gut into reduced levels of LPs vector and you got because it really is, Yeah, I think it. You know, it's seems a very core driver of Alzheimer's and not it's funny. Look at the research, it's all very clear out there. But then like the sude people who you know, Alzheimer's specialists who just still have no idea of any of the stuff around got that we good in other areas, but completely ignorant of things like that, which I still find problematic. Means the end result of people aren't getting proper care and we're ignoring a core underlying driver that that that needs to be addressed if we wanted to to prevent this sort of Alzheimer's and the gemmick that we're seeing. And it's so the only they can be getting worse too that.

You so you look at the rea of it. The increasing rates in lots of western nations are scary, and I'd encourage anybody for Australia just to look at the Australian industry of health, of welfare and the deaths that cut the causes of death in Australia, and you just see because they have it mapped out over the year, should just say like dementia was way down to the bottom and it's just gone boom shot way up right, So they bring Alzheimer's into that umbrella.

You so you look at the rea of it. The increasing rates in lots of western nations are scary, and I'd encourage anybody for Australia just to look at the Australian industry of health, of welfare and the deaths that cut the causes of death in Australia, and you just see because they have it mapped out over the year, should just say like dementia was way down to the bottom and it's just gone boom shot way up right, So they bring Alzheimer's into that umbrella.

And these things should worry is I thought that some one amazing that we don't seem to be too bothered by. You know, there's huge rate of OBC in our kids about using kids or this huge boom of Alzheimer's nearly as much as we should. I mean, there'll be people like you or I who are like, this is incredible stuff. We need to be worried about the people that are making decisions around what's a lad in our food supply, which we know there is a huge correlation here. Like it's mind blowing that we're not making deeper changes in terms of what's allowed to be putting our food, what can we label as food because all these pseudo foods that people are consuming that are actually directly causing this are totally loud in our current health.

And these things should worry is I thought that some one amazing that we don't seem to be too bothered by. You know, there's huge rate of OBC in our kids about using kids or this huge boom of Alzheimer's nearly as much as we should. I mean, there'll be people like you or I who are like, this is incredible stuff. We need to be worried about the people that are making decisions around what's a lad in our food supply, which we know there is a huge correlation here. Like it's mind blowing that we're not making deeper changes in terms of what's allowed to be putting our food, what can we label as food because all these pseudo foods that people are consuming that are actually directly causing this are totally loud in our current health.

You know. Yeah, and you know this whole thing if it looks if it doesn't look like it's been alive recently and minimally interfered with by humans, then don't dat the bloody stuff or I talk about the early twenty road, right, So twenty percent treat stuff, but eighty percent of the stuff that goes into your gub on a daily basis shue have been alive recently and minimally interfered with by humans. Because I am a big believer, and it's Professor Philis Jaka who is the driver of the nutritional psychiatry movement. She said that the ultra processed food system or the food global food industry is the biggest driver of chronic disease in the world without exception. And I think she's absolutely right. You only have to look at like what has changed from I saw a photograph the other day of Bathurst in the nineteen seventies, the crowd and there's a huge amount of people in it, just as you was mentioned earlier on not one obese person there, not one, right, And that was in nineteen seventy seven. And you look back and that you can just look at all photographs of people at beaches in the fifties and sixties to seven. It just we didn't have hardly any of it. And now it is the norm to be overweight at orbees. What has changed? The big thing that changes our diet and all the plastics, these forever chemicals that you talked about, right, which go hand in hand with the diet and the food packaging and all of that.

You know. Yeah, and you know this whole thing if it looks if it doesn't look like it's been alive recently and minimally interfered with by humans, then don't dat the bloody stuff or I talk about the early twenty road, right, So twenty percent treat stuff, but eighty percent of the stuff that goes into your gub on a daily basis shue have been alive recently and minimally interfered with by humans. Because I am a big believer, and it's Professor Philis Jaka who is the driver of the nutritional psychiatry movement. She said that the ultra processed food system or the food global food industry is the biggest driver of chronic disease in the world without exception. And I think she's absolutely right. You only have to look at like what has changed from I saw a photograph the other day of Bathurst in the nineteen seventies, the crowd and there's a huge amount of people in it, just as you was mentioned earlier on not one obese person there, not one, right, And that was in nineteen seventy seven. And you look back and that you can just look at all photographs of people at beaches in the fifties and sixties to seven. It just we didn't have hardly any of it. And now it is the norm to be overweight at orbees. What has changed? The big thing that changes our diet and all the plastics, these forever chemicals that you talked about, right, which go hand in hand with the diet and the food packaging and all of that.

Exactly when we're buying the process food it's going to cover with, we're cover with plastical stuff too, so we get extra dose to the plastic too.

Exactly when we're buying the process food it's going to cover with, we're cover with plastical stuff too, so we get extra dose to the plastic too.

Yeah, so's and do we know anything about the role of these forever chemicals in the gut because we have now found that. I saw some research the other day one hundred percent of placentas that were tested in the United States had got forever chemicals microplastics in the placenta. Right, we now know we've seen it in the human brain as well, and we've seen it in other organs. Do we know the role that they play in the gut yet?

Yeah, so's and do we know anything about the role of these forever chemicals in the gut because we have now found that. I saw some research the other day one hundred percent of placentas that were tested in the United States had got forever chemicals microplastics in the placenta. Right, we now know we've seen it in the human brain as well, and we've seen it in other organs. Do we know the role that they play in the gut yet?

I would argue it's under research. But that's again probably the last ten years people started to look at that and it looks like there's a pretty common pattern that those rigor chemicals harm beneficial microbes and increased levels of proty bacteria. Yeah, and it's just kind of the same pattern we see with the ultra precess food dies to the increased protebacta reduce levels of benifh bacteria becaues some of the Even though stuff that we had like triclecan as a compound that anti antacific is added to toothpaste. In some parts of the world it's classic the carcinine not allowed, but in other parts, like Australia, added to toothpaste we can frush our teeth with it. Actually, again it kills our benished bactery and causes these blooms of prote bactery even when in the doses we're getting from toothpaste. It's just like, why is this stuff allowed? You know, it's just crazy. So it's like we're being bombarded on all sides, from cosmetics to our food supply that these things that are causing microboob harm that don't necessarily get the airplay of antabotics. More people are aware of what it's causing harm, and they do, but they at least they have some therapeutic benefit in certain situations. Other things do not all of you, and there's no reason why that we should be consuming them.

I would argue it's under research. But that's again probably the last ten years people started to look at that and it looks like there's a pretty common pattern that those rigor chemicals harm beneficial microbes and increased levels of proty bacteria. Yeah, and it's just kind of the same pattern we see with the ultra precess food dies to the increased protebacta reduce levels of benifh bacteria becaues some of the Even though stuff that we had like triclecan as a compound that anti antacific is added to toothpaste. In some parts of the world it's classic the carcinine not allowed, but in other parts, like Australia, added to toothpaste we can frush our teeth with it. Actually, again it kills our benished bactery and causes these blooms of prote bactery even when in the doses we're getting from toothpaste. It's just like, why is this stuff allowed? You know, it's just crazy. So it's like we're being bombarded on all sides, from cosmetics to our food supply that these things that are causing microboob harm that don't necessarily get the airplay of antabotics. More people are aware of what it's causing harm, and they do, but they at least they have some therapeutic benefit in certain situations. Other things do not all of you, and there's no reason why that we should be consuming them.

Yeah, so let's talk about antibiotics right now. So we just had a chat but before we came on. So I am currently on a course of antibiotics. I'm not happy about it. I mean, there is very compelling research about the amount of courses of antibiotics that you're on throughout your life has a significant impact on the healthier gut, microbiome, and all sorts of other health conditions, particularly obasically in diabetes. Now, I had to have one because I had an infection in a tooth and I was saying to you. The doctor did a three D X ray which actually showed the infection had penetrated to the riysth of my mouth into the sinus, and it was amazing. You could see that the immune tiste had dumped all this inflammation on it. Right, So this was a no brain This is a case endpoint where antibiotics can be life savers, right, because if I was a cave man, that shit could kill me. So what do we do when we're on course of antibiotics? Is it? Because I've heard conflicting evidence about whether or not you should take probiotics. Some people say it's no point in doing it until you finish the course. Other people have said a couple of ours after your antibiotic, then take a probiotic. So what what what is your understanding of it and what particular types and does it depend on the antibiotic that you're on. What do we know about this?

Yeah, so let's talk about antibiotics right now. So we just had a chat but before we came on. So I am currently on a course of antibiotics. I'm not happy about it. I mean, there is very compelling research about the amount of courses of antibiotics that you're on throughout your life has a significant impact on the healthier gut, microbiome, and all sorts of other health conditions, particularly obasically in diabetes. Now, I had to have one because I had an infection in a tooth and I was saying to you. The doctor did a three D X ray which actually showed the infection had penetrated to the riysth of my mouth into the sinus, and it was amazing. You could see that the immune tiste had dumped all this inflammation on it. Right, So this was a no brain This is a case endpoint where antibiotics can be life savers, right, because if I was a cave man, that shit could kill me. So what do we do when we're on course of antibiotics? Is it? Because I've heard conflicting evidence about whether or not you should take probiotics. Some people say it's no point in doing it until you finish the course. Other people have said a couple of ours after your antibiotic, then take a probiotic. So what what what is your understanding of it and what particular types and does it depend on the antibiotic that you're on. What do we know about this?

Yeah, good question. I think the first thing is just making sure you need it the analyotic and I always just people really cutch the prescriber for something like you're dealing with, Yeah, you know, for a bone infection or something. Yet totally you know, patient of the week that that feller broke the risk and had to have you know, surgery in the metal bits in their armed whole things. Yeah, they need antibotics to prevent any sort of bone infection, no doubt. But we also know that I think for Australian data show that just a couple of years ago from viral bronchitis, eighty percent of people who went to their GP were prescribed antibotics.

Yeah, good question. I think the first thing is just making sure you need it the analyotic and I always just people really cutch the prescriber for something like you're dealing with, Yeah, you know, for a bone infection or something. Yet totally you know, patient of the week that that feller broke the risk and had to have you know, surgery in the metal bits in their armed whole things. Yeah, they need antibotics to prevent any sort of bone infection, no doubt. But we also know that I think for Australian data show that just a couple of years ago from viral bronchitis, eighty percent of people who went to their GP were prescribed antibotics.

For viral and they do nothing virus it's got harm.

For viral and they do nothing virus it's got harm.

You know, So just be aware of that that one don't request them for viral infections to question whether they're really needed in this case, because sometimes they are, and they are live in life saving and they need them. So when you do need them, the research, it's very clear if you take the right probotic during the course, you get less side effets, and you get less microbiome harm and you get better restoration of the ecosystem afterwards. Okay, so that is clear, and the idea that you should wait till afterwards is kind of not based on evidence anymore. I think it was a theoretical concept from forty years ago, before we had studies showing that the opposite, we get better outcomes. It's not to say that every probotic can be helpful, because there was one study that made huge worldwide airplayers and Israeli study where they found a one particular probotic supplement on the Israeli market that when given alongside of course of antobotics, actually slowed down the microbiome restoration compared to doing nothing at all. Yeah, and it turns out that the lack of silite in that specific supplement, so they created compounds that prevented the growth of good bacteria. Okay, there's potential for harm if you just take a random products someone with no evidence on it, I think is relatively small, but there is. But we have you know, you know, I've got a website called Product Advisor, which is actually an evidence based database where you can actually look at at probodic research and you can type in antibotics when it comes up with the product strains that have been using human clinical trials and the effects in those studies and the level evidence where there it's be meta analysis or rand Rise controlled trial or open label trial. Try to make this easier to prescribe it products an evidence based way and using the right one for the right condition. And there is a bug Lacy skill surrand Nooses g G that has you know, meta analysis level data for prevention of that rock associated side epics or sacrifices, servy a CI variety, bloody eye.