What if the missing piece in diagnosing, and even treating, a rare disease was hiding in plain sight? For one such condition, mevalonate kinase deficiency, which affects at least one in a million people globally, that piece may now have been uncovered.

In this episode, Garvan's Professor Mike Rogers shares insights from more than a decade of research into this condition, and explains how his findings are helping reveal a bigger picture.

What if the missing piece in diagnosing, and even treating, a rare disease was hiding in plain sight? For one such condition, mevalonate kinase deficiency, which affects at least one in a million people globally, that piece may now have been uncovered.
In this episode, Garvan's Professor Mike Rogers shares insights from more than a decade of research into this condition, and explains how his findings are helping reveal a bigger picture.

We dive deep into the minds of our amazing researchers to find out how they tick and how they are working to make our lives better.

We dive deep into the minds of our amazing researchers to find out how they tick and how they are working to make our lives better.

Medical Minds

The missing piece of the puzzle

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/03c7fe37-f422-4711-be8b-b42d000d35d5/transcript

Immunotherapy has revolutionised the treatment of many blood cancers, harnessing the immune system so our bodies can fight back. But for solid tumours, like pancreatic cancer with a survival rate of just 13%, that breakthrough has remained frustratingly out of reach. 

In this episode, we explore why the immune system struggles to attack these tumours and how the physical environment inside cancers can shape the way immune cells behave.

We hear from Garvan's Associate Professor Maté Biro, whose research maps how cells move inside of tumours, with the goal of uncovering new strategies to improve cancer treatment.

Immunotherapy has revolutionised the treatment of many blood cancers, harnessing the immune system so our bodies can fight back. But for solid tumours, like pancreatic cancer with a survival rate of just 13%, that breakthrough has remained frustratingly out of reach.&nbsp;
In this episode, we explore why the immune system struggles to attack these tumours and how the physical environment inside cancers can shape the way immune cells behave.
We hear from Garvan's Associate Professor Mat&eacute; Biro, whose research maps how cells move inside of tumours, with the goal of uncovering new strategies to improve cancer treatment.

Calling killer cells to action

Arthritis affects millions of people, but the underlying causes are still not fully understood. What makes the immune system that normally protects us suddenly attack our joints? And why do arthritis flares seem to arrive without warning?

In this episode, we explore how certain immune cells or signals might be responsible for switching inflammation on.

We hear from Garvan's Dr Etienne Masle-Farquhar, who is mapping these processes in both rheumatoid arthritis and osteoarthritis, with the goal of predicting flares earlier and guiding more effective treatment.

Arthritis affects millions of people, but the underlying causes are still not fully understood. What makes the immune system that normally protects us suddenly attack our joints? And why do arthritis flares seem to arrive without warning?
In this episode, we explore how certain immune cells or signals might be responsible for switching inflammation on.
We hear from Garvan's Dr Etienne Masle-Farquhar, who is mapping these processes in both rheumatoid arthritis and osteoarthritis, with the goal of predicting flares earlier and guiding more effective treatment.

Arthritis: uncovering pathways to better treatment   

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/693e3518-8816-44e3-b70f-b3b00147ab9f/transcript

For decades, the fight against cancer has focused on killing the tumour cell. We treated cancer like an isolated entity that needed to be destroyed – but what if we’ve been looking at the wrong target?

In this episode, we delve into the critical insight that cancer is not just a rogue cell – it’s an entire ecosystem – and that ecosystem is the key to unlocking a new class of cures.

We hear from Garvan's Dr Ankur Sharma, who is using precision technology to dissect how the environment around liver cancers allows them to grow unchecked. The ultimate goal for this research is to develop better diagnostics and treatments for this deadly cancer.

For decades, the fight against cancer has focused on killing the tumour cell. We treated cancer like an isolated entity that needed to be destroyed &ndash; but what if we&rsquo;ve been looking at the wrong target?
In this episode, we delve into the critical insight that cancer is not just a rogue cell &ndash; it&rsquo;s an entire ecosystem &ndash; and that ecosystem is the key to unlocking a new class of cures.
We hear from Garvan's Dr Ankur Sharma, who is using precision technology to dissect how the environment around liver cancers allows them to grow unchecked. The ultimate goal for this research is to develop better diagnostics and treatments for this deadly cancer.

Liver cancer: discovering the next generation of therapy targets

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/e8a23dde-e99f-4d93-8323-b38d0189a6fd/transcript

The missing piece of the puzzle

Medical Minds

In 1 playlist(s)

Medical Minds

Social links

Follow podcast

Recent clips