Pancreatic cancer can surround itself with dense scar tissue, creating a kind of fortress that makes tumours incredibly difficult to treat. So, how do we find a way through?

In this episode, Garvan researcher Dr Brooke Pereira explains the role of this complex tumour environment, and reveals how better understanding it could be the key to uncovering new treatment options.

Pancreatic cancer can surround itself with dense scar tissue, creating a kind of fortress that makes tumours incredibly difficult to treat. So, how do we find a way through?
In this episode, Garvan researcher Dr Brooke Pereira explains the role of this complex tumour environment, and reveals&nbsp;how better understanding it could be the key to uncovering new treatment options.

We dive deep into the minds of our amazing researchers to find out how they tick and how they are working to make our lives better.

We dive deep into the minds of our amazing researchers to find out how they tick and how they are working to make our lives better.

Medical Minds

Storming the tumour fortress 

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/93317ee4-2f5e-4964-8fad-b4bb005b3150/transcript

Our immune system is like a well-trained security network, constantly scanning the body for threats. So, how is it that some harmful cells manage to slip by unnoticed?

In this episode, we speak to computational biologist, Dr Clare Puttick, about how cancer cells can evade detection by disrupting the molecular “flags” that would normally mark them for attack.

Her research is uncovering new ways to expose these hidden cells and could offer fresh insights into diseases where the immune system doesn’t behave as expected, including endometriosis.

 

Our immune system is like a well-trained security network, constantly scanning the body for threats. So, how is it that some harmful cells manage to slip by unnoticed?
In this episode, we speak to computational biologist, Dr Clare Puttick, about how cancer cells can evade detection by disrupting the molecular &ldquo;flags&rdquo; that would normally mark them for attack.
Her research is uncovering new ways to expose these hidden cells and could offer fresh insights into diseases where the immune system doesn&rsquo;t behave as expected, including endometriosis.
&nbsp;

Hunting hidden cells

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/a936857b-b908-45b7-a925-b46c017bc1e2/transcript

What if the missing piece in diagnosing, and even treating, a rare disease was hiding in plain sight? For one such condition, mevalonate kinase deficiency, which affects at least one in a million people globally, that piece may now have been uncovered.

In this episode, Garvan's Professor Mike Rogers shares insights from more than a decade of research into this condition, and explains how his findings are helping reveal a bigger picture.

What if the missing piece in diagnosing, and even treating, a rare disease was hiding in plain sight? For one such condition, mevalonate kinase deficiency, which affects at least one in a million people globally, that piece may now have been uncovered.
In this episode, Garvan's Professor Mike Rogers shares insights from more than a decade of research into this condition, and explains how his findings are helping reveal a bigger picture.

The missing piece of the puzzle

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/03c7fe37-f422-4711-be8b-b42d000d35d5/transcript

Immunotherapy has revolutionised the treatment of many blood cancers, harnessing the immune system so our bodies can fight back. But for solid tumours, like pancreatic cancer with a survival rate of just 13%, that breakthrough has remained frustratingly out of reach. 

In this episode, we explore why the immune system struggles to attack these tumours and how the physical environment inside cancers can shape the way immune cells behave.

We hear from Garvan's Associate Professor Maté Biro, whose research maps how cells move inside of tumours, with the goal of uncovering new strategies to improve cancer treatment.

Immunotherapy has revolutionised the treatment of many blood cancers, harnessing the immune system so our bodies can fight back. But for solid tumours, like pancreatic cancer with a survival rate of just 13%, that breakthrough has remained frustratingly out of reach.&nbsp;
In this episode, we explore why the immune system struggles to attack these tumours and how the physical environment inside cancers can shape the way immune cells behave.
We hear from Garvan's Associate Professor Mat&eacute; Biro, whose research maps how cells move inside of tumours, with the goal of uncovering new strategies to improve cancer treatment.

Storming the tumour fortress

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