Feeling down from time to time is normal, but how can you tell when sadness is something more – like major depressive disorder? We spoke with Jessi Gold, MD, MS, the first chief wellness officer of the University of Tennessee system and bestselling author of How Do You Feel?, to unpack the complexities of depression. She breaks down the differences between temporary low mood and clinical depression, the role of genetics and medical conditions, and how daily stressors can contribute. We also dive into treatment options -- from therapy to medication -- and the importance of recognizing when it’s time to seek help.