Perimenopause is the natural transition leading into menopause, marked by erratic fluctuations in estrogen and progesterone. These unpredictable shifts can trigger emotional, cognitive, and physical changes – often years before menopause officially begins. We spoke with Megan Spence, PsyD, PMH-C, a licensed clinical psychologist, about the whole-body experience of perimenopause, including mood and memory changes, the structural and social factors that place some groups at higher risk, available hormonal and non-hormonal treatments, lifestyle strategies that may help, and when – and how – to ask for support. Your symptoms matter, and you deserve informed, compassionate care.

Credits
Host: Neha Pathak, MD, FACP, DipABLM
Guest: Megan Spence, PsyD, PMH-C
Producer/Editor: Lauren Summers
Show Notes: Lauren Summers

<a href="https://www.webmd.com/menopause/guide-chapter-perimenopause-overview" data-testid="linkable-text">Perimenopause</a> is the natural transition leading into menopause, marked by erratic fluctuations in estrogen and progesterone. These unpredictable shifts can trigger&nbsp;<a href="https://www.webmd.com/menopause/emotional-roller-coaster" data-testid="linkable-text">emotional</a>, cognitive, and physical changes &ndash; often years before menopause officially begins. We spoke with <a href="https://www.psychologytoday.com/us/therapists/megan-spence-alameda-ca/869278" data-testid="linkable-text">Megan Spence, PsyD, PMH-C</a>, a licensed clinical psychologist, about the whole-body experience of perimenopause, including mood and memory changes, the structural and social factors that place some groups at higher risk, available hormonal and non-hormonal treatments, lifestyle strategies that may help, and when &ndash; and how &ndash; to ask for support. Your symptoms matter, and you deserve informed, compassionate care.
Credits
<ul>
<li aria-level="1">Host: Neha Pathak, MD, FACP, DipABLM</li>
<li aria-level="1">Guest: Megan Spence, PsyD, PMH-C</li>
<li aria-level="1">Producer/Editor: Lauren Summers</li>
<li aria-level="1">Show Notes: Lauren Summers</li>
</ul>

WebMD Chief Physician Editor Neha Pathak, MD, and Chief Medical Officer, John Whyte, MD, MPH, explore fascinating stories to find the unexpected things that help us understand our health.

Health Discovered

Perimenopause: Understanding the Emotional, Cognitive, and Physical Changes

While heart disease may be the number-one killer in the United States, kidney disease is the silent partner we rarely discuss. It often develops quietly, with no pain or clear symptoms until advanced stages. What should we know about kidney health and kidney diseases? We spoke with Kirk Campbell, MD, president of the National Kidney Foundation, about the kidneys’ vital roles – from red blood cell production to supporting heart function – why testing matters, which tests to request, and the importance of knowing your numbers. If you’re at risk, don’t hesitate to advocate for screening at your appointments.

Credits
Host: Neha Pathak, MD, FACP, DipABLM
Producer/Editor: Lauren Summers
Show Notes: Lauren Summers
Guest: Kirk Campbell, MD

While heart disease may be the number-one killer in the United States, <a href="https://www.webmd.com/a-to-z-guides/understanding-kidney-disease-basic-information" data-testid="linkable-text">kidney disease</a> is the silent partner we rarely discuss. It often develops quietly, with no pain or clear symptoms until advanced stages. What should we know about kidney health and kidney diseases? We spoke with <a href="https://www.kidney.org/bio/dr-kirk-campbell" data-testid="linkable-text">Kirk Campbell, MD</a>, president of the <a href="https://www.kidney.org/" data-testid="linkable-text">National Kidney Foundation</a>, about the kidneys&rsquo; vital roles &ndash; from red blood cell production to supporting heart function &ndash; why testing matters, which <a href="https://www.webmd.com/a-to-z-guides/glomerular-filtration-rate" data-testid="linkable-text">tests to request</a>, and the importance of knowing your numbers. If you&rsquo;re at risk, don&rsquo;t hesitate to advocate for screening at your appointments.
Credits
<ul>
<li aria-level="1">Host: Neha Pathak, MD, FACP, DipABLM</li>
<li aria-level="1">Producer/Editor: Lauren Summers</li>
<li aria-level="1">Show Notes: Lauren Summers</li>
<li aria-level="1">Guest: Kirk Campbell, MD</li>
</ul>

Know Your Numbers: Why Kidney Health Can’t Wait

A lot of us have heard about “high cortisol” in the context of stress. But Cushing’s syndrome, which has recently been in the news, is something very different. It’s pathologic cortisol excess that can quietly drive certain health problems. We spoke with Lewis Blevins, MD, a neuroendocrinologist specializing in pituitary, hypothalamic, and adrenal disorders, about what cortisol is meant to do, what Cushing’s syndrome really is, why diagnosis is often delayed, and what practical steps to take if you suspect something more than everyday stress. We also discuss the path to an accurate diagnosis and shared decision-making grounded in patient education.

Credits
Host: Neha Pathak, MD, FACP, DipABLM
Producer/Editor: Lauren Summers
Show Notes: Lauren Summers
Guest: Lewis Blevins, MD

A lot of us have heard about &ldquo;high <a href="https://www.webmd.com/a-to-z-guides/what-is-cortisol?ref=ro" data-testid="linkable-text">cortisol</a>&rdquo; in the context of stress. But <a href="https://www.webmd.com/a-to-z-guides/cushing-syndrome" data-testid="linkable-text">Cushing&rsquo;s syndrome</a>, which has recently been in the news, is something very different. It&rsquo;s pathologic cortisol excess that can quietly drive certain health problems. We spoke with <a href="https://pituitaryworldnews.org/about-us/lewis-blevins-md/" data-testid="linkable-text">Lewis Blevins, MD</a>, a neuroendocrinologist specializing in pituitary, hypothalamic, and adrenal disorders, about what cortisol is meant to do, what Cushing&rsquo;s syndrome really is, why diagnosis is often delayed, and what practical steps to take if you suspect something more than everyday stress. We also discuss the path to an accurate diagnosis and shared decision-making grounded in patient education.
Credits
<ul>
<li aria-level="1">Host: Neha Pathak, MD, FACP, DipABLM</li>
<li aria-level="1">Producer/Editor: Lauren Summers</li>
<li aria-level="1">Show Notes: Lauren Summers</li>
<li aria-level="1">Guest: Lewis Blevins, MD</li>
</ul>

High Cortisol or Something More? Understanding Cushing’s Syndrome

For many of us in the “sandwich generation” – those raising kids while caring for aging parents – preventive health can feel like one more impossible task on an already full plate. But prevention isn’t just about protecting your future; it’s about preserving your energy so you can show up for the people who need you right now. We spoke with Eduardo Sanchez, MD, MPH, FAHA, chief medical officer for prevention at the American Heart Association, about a practical framework for health and how sleep, stress, mental well-being, and social connection all play a role in heart health, stroke prevention, and even cognitive health. Taking care of yourself isn’t selfish –  it’s preventive medicine that shapes your future.

Additional resources:
Life’s Essential 8
MyLifeCheck
Your Health Care Journey

Credits
Host: Neha Pathak, MD, FACP, DipABLM
Producer/Editor: Lauren Summers
Show Notes: Lauren Summers
Guest: Eduardo Sanchez, MD, MPH, FAHA

For many of us in the &ldquo;sandwich generation&rdquo; &ndash; those raising kids while caring for aging parents &ndash; <a href="https://www.webmd.com/diet/features/4-steps-healthy-lifestyle" data-testid="linkable-text">preventive health</a> can feel like one more impossible task on an already full plate. But prevention isn&rsquo;t just about protecting your future; it&rsquo;s about preserving your energy so you can show up for the people who need you right now. We spoke with <a href="https://www.heart.org/en/about-us/eduardo-sanchez" data-testid="linkable-text">Eduardo Sanchez, MD, MPH, FAHA</a>, chief medical officer for prevention at the <a href="https://www.heart.org/en/" data-testid="linkable-text">American Heart Association</a>, about a practical framework for health and how sleep, stress, mental well-being, and social connection all play a role in heart health, stroke prevention, and even cognitive health. Taking care of yourself isn&rsquo;t selfish &ndash;&nbsp; it&rsquo;s preventive medicine that shapes your future.
Additional resources: <a href="https://protect.checkpoint.com/v2/r01/___https://www.heart.org/en/healthy-living/healthy-lifestyle/lifes-essential-8___.YzJ1OndlYm1kOmM6ZzozM2M2YzBhMWVhMzQ2ODAxYzU0OTZlNzkwMDc4NjRiZTo3OjNjMTA6ZTllODYyNjVjNDY0MGQ1NjA5ZjdmZDdhNTcwMjQwODE1NjNkMDQwYzFhODQ2N2NjNjZlNTM1MzVkODJhZTdjODpoOlQ6Rg" data-testid="linkable-text">Life&rsquo;s Essential 8 </a><a href="http://mylifecheck/" data-testid="linkable-text">MyLifeCheck </a><a href="https://www.heart.org/en/health-topics/consumer-healthcare" data-testid="linkable-text">Your Health Care Journey</a>
Credits
<ul>
<li aria-level="1">Host: Neha Pathak, MD, FACP, DipABLM</li>
<li aria-level="1">Producer/Editor: Lauren Summers</li>
<li aria-level="1">Show Notes: Lauren Summers</li>
<li>Guest: Eduardo Sanchez, MD, MPH, FAHA</li>
</ul>

Perimenopause: Understanding the Emotional, Cognitive, and Physical Changes

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