Phages are viruses that attack bacteria. People have been using phages to treat infections for over a hundred years, but in most cases they just don't work as well as antibiotics. 

Paul Garofolo is the co-founder and CEO of Locus Biosciences. His problem is this: How do you genetically engineer phages to be more effective at curing disease? 

In this episode, Paul explains: 
Why wild phages never completely wipe out a bacterial infection
How to engineer phages with CRISPR to kill bacteria more effectively
The clinical trial testing phage therapy for chronic, recurrent UTIs
Why persistent bacteria may contribute to autoimmune conditions like Crohn's disease
How to use robots and AI to create phage cocktails from wastewater

Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram 
Email us at problem@pushkin.fm 
Follow Pushkin on Instagram, LinkedIn or X 
Listen to Jacob’s other show, Business History 
To listen to the show early and ad free, sign up for Pushkin+

Phages are viruses that attack bacteria. People have been using phages to treat infections for over a hundred years, but in most cases they just don't work as well as antibiotics.&nbsp;
Paul Garofolo is the co-founder and CEO of Locus Biosciences. His problem is this: How do you genetically engineer phages to be more effective at curing disease?&nbsp;
In this episode, Paul explains:&nbsp;
<ul>
<li>Why wild phages never completely wipe out a bacterial infection</li>
<li>How to engineer phages with CRISPR to kill bacteria more effectively</li>
<li>The clinical trial testing phage therapy for chronic, recurrent UTIs</li>
<li>Why persistent bacteria may contribute to autoimmune conditions like Crohn's disease</li>
<li>How to use robots and AI to create phage cocktails from wastewater</li>
</ul>
Connect with us:
<ul>
<li>Follow Jacob Goldstein on <a href="https://www.linkedin.com/in/jacob-goldstein-888a2441/" data-airgap-id="10">LinkedIn</a>, <a href="https://x.com/jacobgoldstein?lang=en" data-airgap-id="11">X</a> and <a href="https://www.instagram.com/jacobjgoldstein/" data-airgap-id="12">Instagram&nbsp;</a></li>
<li>Email us at <a href="mailto:problem@pushkin.fm" data-airgap-id="13">problem@pushkin.fm</a>&nbsp;</li>
<li>Follow Pushkin on <a href="https://www.instagram.com/pushkinpods/" data-airgap-id="14">Instagram</a>,<a href="https://www.linkedin.com/company/pushkin-industries/posts/?feedView=all" data-airgap-id="15"> LinkedIn</a> or <a href="https://x.com/pushkinpods?lang=en" data-airgap-id="16">X</a>&nbsp;</li>
<li>Listen to Jacob&rsquo;s other show, <a href="https://podcasts.apple.com/us/podcast/business-history/id1844409167" data-airgap-id="17">Business History&nbsp;</a></li>
<li>To listen to the show early and ad free, sign up for <a href="https://www.pushkin.fm/join-pushkin" data-airgap-id="18">Pushkin+</a></li>
</ul>

Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with entrepreneurs and engineers tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with&nbsp;entrepreneurs and engineers&nbsp;tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better.
iHeartMedia is the exclusive podcast partner of Pushkin Industries.

What's Your Problem?

Every week on What’s Your Problem, entrepreneurs and engineers talk about the future they’re trying to build – and the problems they have to solve to get there.

How do you take a drone delivery service you’ve built in Rwanda and make it work in North Carolina? How do you convince people to buy a house on the Internet? How do you sell thousands of dog ramps to weiner dogs all across America when a pandemic breaks the global supply chain? 

Hosted by former Planet Money host Jacob Goldstein, What’s Your Problem helps listeners understand the problems really smart people are trying to solve right now.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

Using Viruses to Fight Disease

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/9f599782-8645-43fd-befb-b481016d7571/transcript

I'm here with a preview of Blockers, a new audiobook from Michael Lewis, the author of Liars Poker, Moneyball, The Big Short and more. In Blockers, Lewis tells the story of a handful of people who dedicated their careers to public service—until the Department of Government Efficiency decided they were a problem. These were people who believed they had a calling—people who kept American's sensitive tax data out of the wrong hands, made sure that politicians and civil servants played by the rules, and figured out how to stop wildfires from destroying suburban neighborhoods—and then discovered they were no longer wanted.

Here's an excerpt from the audiobook. You can buy the audiobook exclusively at blockers.fm. 

I'm here with a preview of Blockers, a new audiobook from Michael Lewis, the author of Liars Poker, Moneyball, The Big Short and more. In Blockers, Lewis tells the story of a handful of people who dedicated their careers to public service&mdash;until the Department of Government Efficiency decided they were a problem. These were people who believed they had a calling&mdash;people who kept American's sensitive tax data out of the wrong hands, made sure that politicians and civil servants played by the rules, and&nbsp;figured out how to stop wildfires from destroying suburban neighborhoods&mdash;and then discovered they were no longer wanted.
Here's an excerpt from the audiobook. You can buy the audiobook exclusively at <a href="http://blockers.fm/" data-airgap-id="17">blockers.fm</a>.&nbsp;

Blockers | A Preview of Michael Lewis's New Audiobook

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/aae25215-6e31-4660-aa49-b4da00f45fa3/transcript

We’ve all heard that nothing ever gets deleted from the internet. Luke Arrigoni says that just isn’t true. His company deletes thousands of deepfakes every day.

Luke is the founder and CEO of Loti, and his problem is this: How do you turn the Internet into a place where people have more control over their name, image and likeness?

Tens of thousands of famous people pay Loti to scour the internet and take down deepfakes and unapproved endorsements. But in Luke's telling, this is just the beginning. The company will soon allow celebrities to license their likeness for use in AI videos, and it also plans to start offering its services to ordinary people. 

In this episode, Luke explains: 
The harm that online deepfakes and impersonations can cause 
How Loti automates tens of thousands of takedowns per day 
Why the law may soon make it easier to fight deepfakes 
Why celebrities are beginning to license their likenesses to AI platforms 
AI’s role in the future of human creativity 

Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram 
Email us at problem@pushkin.fm 
Follow Pushkin on Instagram, LinkedIn or X 
Listen to Jacob’s other show, Business History 
To listen to the show ad free, sign up for Pushkin+

We&rsquo;ve all heard that nothing ever gets deleted from the internet. Luke Arrigoni says that just isn&rsquo;t true. His company deletes thousands of deepfakes every day.
Luke is the founder and CEO of Loti, and his problem is this: How do you turn the Internet into a place where people have more control over their name, image and likeness?
Tens of thousands of famous people pay Loti to scour the internet and take down deepfakes and unapproved endorsements. But in Luke's telling, this is just the beginning. The company will soon allow celebrities to license their likeness for use in AI videos, and it also plans to start offering its services to ordinary people.&nbsp;
In this episode, Luke explains:&nbsp;
<ul>
<li>The harm that online deepfakes and impersonations can cause&nbsp;</li>
<li>How Loti automates tens of thousands of takedowns per day&nbsp;</li>
<li>Why the law may soon make it easier to fight deepfakes&nbsp;</li>
<li>Why celebrities are beginning to license their likenesses to AI platforms&nbsp;</li>
<li>AI&rsquo;s role in the future of human creativity&nbsp;</li>
</ul>
Connect with us:
<ul>
<li>Follow Jacob Goldstein on <a href="https://www.linkedin.com/in/jacob-goldstein-888a2441/" data-airgap-id="12">LinkedIn</a>, <a href="https://x.com/jacobgoldstein?lang=en" data-airgap-id="13">X</a> and <a href="https://www.instagram.com/jacobjgoldstein/" data-airgap-id="14">Instagram&nbsp;</a></li>
<li>Email us at <a href="mailto:problem@pushkin.fm" data-airgap-id="15">problem@pushkin.fm</a>&nbsp;</li>
<li>Follow Pushkin on <a href="https://www.instagram.com/pushkinpods/" data-airgap-id="16">Instagram</a>,<a href="https://www.linkedin.com/company/pushkin-industries/posts/?feedView=all" data-airgap-id="17"> LinkedIn</a> or <a href="https://x.com/pushkinpods?lang=en" data-airgap-id="18">X</a>&nbsp;</li>
<li>Listen to Jacob&rsquo;s other show, <a href="https://podcasts.apple.com/us/podcast/business-history/id1844409167" data-airgap-id="19">Business History&nbsp;</a></li>
<li>To listen to the show ad free, sign up for <a href="https://www.pushkin.fm/join-pushkin" data-airgap-id="20">Pushkin+</a></li>
</ul>

Can We Defeat Deepfakes?

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/f1e81bf1-ded2-408f-8d17-b4d60013511b/transcript

Before 1450, books were written out by hand. It was slow and expensive. But Johannes Gutenberg borrowed a ton of money to create a printing press that could crank out Bibles and pamphlets and documents in huge numbers. Science, politics and philosophy were all up-ended. 

For example, the Catholic Church seized on the invention to sell special certificates absolving people of their sins – a move that made money, but caused a permanent schism in Christianity.   

And Gutenberg too found himself in trouble – when a financier sued the inventor to reclaim his loan, plus interest. 

Enjoy this episode from Business History, another Pushkin podcast. 

Before 1450, books were written out by hand. It was slow and expensive. But Johannes Gutenberg borrowed a ton of money to create a printing press that could crank out Bibles and pamphlets and documents in huge numbers. Science, politics and philosophy were all up-ended.&nbsp;
For example, the Catholic Church seized on the invention to sell special certificates absolving people of their sins &ndash; a move that made money, but caused a permanent schism in Christianity.&nbsp;&nbsp;&nbsp;
And Gutenberg too found himself in trouble &ndash; when a financier sued the inventor to reclaim his loan, plus interest.&nbsp;
Enjoy this episode from&nbsp;<a href="https://www.pushkin.fm/podcasts/business-history" data-airgap-id="13">Business History</a>, another Pushkin podcast.&nbsp;

The Printing Press: The Invention Built on Debt and Sin… from Business History 

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/1c025c44-0572-4e4e-95d6-b4ce0144cdd0/transcript

Using Viruses to Fight Disease

In 1 playlist(s)

What's Your Problem?

Social links

Follow podcast

Recent clips