 Mike Blue is the CEO of HistoSonics. The company recently developed a device that uses ultrasound to destroy tumors.

On today’s show, Mike talks about how a garage-built prototype became an FDA-approved machine; changing the company’s story after a failed clinical trial; and why he loves being a salesman but hates most sales pitches.

Mike Blue is the CEO of HistoSonics. The company recently developed a device that uses ultrasound to destroy tumors. On today&rsquo;s show, Mike talks about how a garage-built prototype became an FDA-approved machine; changing the company&rsquo;s story after a failed clinical trial; and why he loves being a salesman but hates most sales pitches.

Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with entrepreneurs and engineers tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with&nbsp;entrepreneurs and engineers&nbsp;tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better.
iHeartMedia is the exclusive podcast partner of Pushkin Industries.

What's Your Problem?

Every week on What’s Your Problem, entrepreneurs and engineers talk about the future they’re trying to build – and the problems they have to solve to get there.

How do you take a drone delivery service you’ve built in Rwanda and make it work in North Carolina? How do you convince people to buy a house on the Internet? How do you sell thousands of dog ramps to weiner dogs all across America when a pandemic breaks the global supply chain? 

Hosted by former Planet Money host Jacob Goldstein, What’s Your Problem helps listeners understand the problems really smart people are trying to solve right now.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

Using Sound Waves to Destroy Tumors

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/ad565e33-42ce-49c5-a766-b39300f9f98c/transcript

Before 1450, books were written out by hand. It was slow and expensive. But Johannes Gutenberg borrowed a ton of money to create a printing press that could crank out Bibles and pamphlets and documents in huge numbers. Science, politics and philosophy were all up-ended. 

For example, the Catholic Church seized on the invention to sell special certificates absolving people of their sins – a move that made money, but caused a permanent schism in Christianity.   

And Gutenberg too found himself in trouble – when a financier sued the inventor to reclaim his loan, plus interest. 

Enjoy this episode from Business History, another Pushkin podcast. 

Before 1450, books were written out by hand. It was slow and expensive. But Johannes Gutenberg borrowed a ton of money to create a printing press that could crank out Bibles and pamphlets and documents in huge numbers. Science, politics and philosophy were all up-ended.&nbsp;
For example, the Catholic Church seized on the invention to sell special certificates absolving people of their sins &ndash; a move that made money, but caused a permanent schism in Christianity.&nbsp;&nbsp;&nbsp;
And Gutenberg too found himself in trouble &ndash; when a financier sued the inventor to reclaim his loan, plus interest.&nbsp;
Enjoy this episode from&nbsp;<a href="https://www.pushkin.fm/podcasts/business-history" data-airgap-id="13">Business History</a>, another Pushkin podcast.&nbsp;

The Printing Press: The Invention Built on Debt and Sin… from Business History 

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/1c025c44-0572-4e4e-95d6-b4ce0144cdd0/transcript

Everybody’s worried about the risks of AI. So we called up one of the most insightful writers we know on the subject: Zvi Mowshowitz. Zvi writes about AI and AI risks at his substack, Don’t Worry About the Vase. Zvi’s problem is this: How do we prevent artificial intelligence from killing everyone? 

In this episode, Zvi explains: 
Why it’s often useful to anthropomorphize AI 
What this summer’s Hugging Face attack tells us about the nature of AI
 What increasing AI capability means for cybersecurity risk
 Whether and when we should pause AI development
Why powerful pen-weight models may remove the last reliable points of control

Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram 
Email us at problem@pushkin.fm 
Follow Pushkin on Instagram, LinkedIn or X 
Listen to Jacob’s other show, Business History 
To listen to the show ad free, sign up for Pushkin+ 

Everybody&rsquo;s worried about the risks of AI. So we called up one of the most insightful writers we know on the subject: Zvi Mowshowitz. Zvi writes about AI and AI risks at his substack, <a href="https://thezvi.substack.com/" data-airgap-id="12">Don&rsquo;t Worry About the Vase</a>. Zvi&rsquo;s problem is this: How do we prevent artificial intelligence from killing everyone?&nbsp;
In this episode, Zvi explains:&nbsp;
<ul>
<li>Why it&rsquo;s often useful to anthropomorphize AI&nbsp;</li>
<li>What this summer&rsquo;s Hugging Face attack tells us about the nature of AI</li>
<li> What increasing AI capability means for cybersecurity risk</li>
<li> Whether and when we should pause AI development</li>
<li>Why powerful pen-weight models may remove the last reliable points of control</li>
</ul>
Connect with us:
<ul>
<li>Follow Jacob Goldstein on <a href="https://www.linkedin.com/in/jacob-goldstein-888a2441/" data-airgap-id="13">LinkedIn</a>, <a href="https://x.com/jacobgoldstein?lang=en" data-airgap-id="14">X</a> and <a href="https://www.instagram.com/jacobjgoldstein/" data-airgap-id="15">Instagram&nbsp;</a></li>
<li>Email us at <a href="mailto:problem@pushkin.fm" data-airgap-id="16">problem@pushkin.fm</a>&nbsp;</li>
<li>Follow Pushkin on <a href="https://www.instagram.com/pushkinpods/" data-airgap-id="17">Instagram</a>,<a href="https://www.linkedin.com/company/pushkin-industries/posts/?feedView=all" data-airgap-id="18"> LinkedIn</a> or <a href="https://x.com/pushkinpods?lang=en" data-airgap-id="19">X</a>&nbsp;</li>
<li>Listen to Jacob&rsquo;s other show, <a href="https://podcasts.apple.com/us/podcast/business-history/id1844409167" data-airgap-id="20">Business History&nbsp;</a></li>
<li>To listen to the show ad free, sign up for <a href="https://www.pushkin.fm/join-pushkin" data-airgap-id="21">Pushkin+</a>&nbsp;</li>
</ul>

Should We Pause AI?

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/6380cb0f-71ad-4f93-b291-b4c701750b7a/transcript

On this bonus episode of What’s Your Problem, Jacob talks to Christine Chase, a Vice President, Financial Consultant at Fidelity Investments. Christine’s problem is this: How do you help clients build a plan to achieve their financial goals? Today’s show is sponsored by Fidelity Investments.

On this bonus episode of What&rsquo;s Your Problem, Jacob talks to Christine Chase, a Vice President, Financial Consultant at Fidelity Investments. Christine&rsquo;s problem is this: How do you help clients build a plan to achieve their financial goals? Today&rsquo;s show is sponsored by Fidelity Investments.

Bonus: Planning for Your Financial Future

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/f7ca05fb-7bd0-4e1c-8583-b4c00155ba68/transcript

Using Sound Waves to Destroy Tumors

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