 Mike Blue is the CEO of HistoSonics. The company recently developed a device that uses ultrasound to destroy tumors.

On today’s show, Mike talks about how a garage-built prototype became an FDA-approved machine; changing the company’s story after a failed clinical trial; and why he loves being a salesman but hates most sales pitches.

Mike Blue is the CEO of HistoSonics. The company recently developed a device that uses ultrasound to destroy tumors. On today&rsquo;s show, Mike talks about how a garage-built prototype became an FDA-approved machine; changing the company&rsquo;s story after a failed clinical trial; and why he loves being a salesman but hates most sales pitches.

Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with entrepreneurs and engineers tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

Every week on What's Your Problem?, former Planet Money host Jacob Goldstein talks with&nbsp;entrepreneurs and engineers&nbsp;tackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What's Your Problem? learns from the thinkers and doers trying to make our future better.
iHeartMedia is the exclusive podcast partner of Pushkin Industries.

What's Your Problem?

Every week on What’s Your Problem, entrepreneurs and engineers talk about the future they’re trying to build – and the problems they have to solve to get there.

How do you take a drone delivery service you’ve built in Rwanda and make it work in North Carolina? How do you convince people to buy a house on the Internet? How do you sell thousands of dog ramps to weiner dogs all across America when a pandemic breaks the global supply chain? 

Hosted by former Planet Money host Jacob Goldstein, What’s Your Problem helps listeners understand the problems really smart people are trying to solve right now.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

Using Sound Waves to Destroy Tumors

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/ad565e33-42ce-49c5-a766-b39300f9f98c/transcript

Nir Barzilai is a physician and a researcher at the Albert Einstein College of Medicine in New York, where he runs the Institute for Geroscience. Nir’s problem is this: How can we use lifestyle changes and drugs to slow the process of aging?

In this episode, Nir explains: 
The search for biological markers of aging
The existing drugs that might reduce the risk of diseases associated with aging
The four key lifestyle factors that every researcher in the field agrees on
What he learned by studying the genes of people who lived to 100
What “geroscience” means, and why it doesn’t have a Wikipedia page 

Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram 
Email us at problem@pushkin.fm 
Follow Pushkin on Instagram, LinkedIn or X 
Listen to Jacob’s other show, Business History
To listen to the show early and ad free, sign up for Pushkin+

Nir Barzilai is a physician and a researcher at the Albert Einstein College of Medicine in New York, where he runs the Institute for Geroscience. Nir&rsquo;s problem is this: How can we use lifestyle changes and drugs to slow the process of aging?
In this episode, Nir explains:&nbsp;
<ul>
<li>The search for biological markers of aging</li>
<li>The existing drugs that might reduce the risk of diseases associated with aging</li>
<li>The four key lifestyle factors that every researcher in the field agrees on</li>
<li>What he learned by studying the genes of people who lived to 100</li>
<li>What &ldquo;geroscience&rdquo; means, and why it doesn&rsquo;t have a Wikipedia page&nbsp;</li>
</ul>
Connect with us:
<ul>
<li>Follow Jacob Goldstein on <a href="https://www.linkedin.com/in/jacob-goldstein-888a2441/" data-airgap-id="11">LinkedIn</a>, <a href="https://x.com/jacobgoldstein?lang=en" data-airgap-id="12">X</a> and <a href="https://www.instagram.com/jacobjgoldstein/" data-airgap-id="13">Instagram&nbsp;</a></li>
<li>Email us at <a href="mailto:problem@pushkin.fm" data-airgap-id="14">problem@pushkin.fm</a>&nbsp;</li>
<li>Follow Pushkin on <a href="https://www.instagram.com/pushkinpods/" data-airgap-id="15">Instagram</a>,<a href="https://www.linkedin.com/company/pushkin-industries/posts/?feedView=all" data-airgap-id="16"> LinkedIn</a> or <a href="https://x.com/pushkinpods?lang=en" data-airgap-id="17">X</a>&nbsp;</li>
<li>Listen to Jacob&rsquo;s other show, <a href="https://podcasts.apple.com/us/podcast/business-history/id1844409167" data-airgap-id="18">Business History</a></li>
<li>To listen to the show early and ad free, sign up for <a href="https://www.pushkin.fm/join-pushkin" data-airgap-id="19">Pushkin+</a></li>
</ul>

Can We Slow Down Aging?

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/3134ceb8-3ac7-487f-9059-b49800fd9965/transcript

Helen Pearson is the author of the book “Beyond Belief: How Evidence Shows What Really Works.” Helen's problem is this: How do you get people to make important decisions based on high-quality evidence, instead of on hunches or habits?

In this episode, Helen explains: 
How a doctor's fatal mistake sparked the evidence-based medicine movement
Why management is so resistant to evidence-based practices
How systematic reviews changed the way she works as a science journalist
Why global trust in science remains high – outside the US
What a randomized trial of pint glasses revealed about preventing violent injuries.

Check out Helen’s book here. 

Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram 
Email us at problem@pushkin.fm 
Follow Pushkin on Instagram, LinkedIn or X 
Listen to Jacob’s other show, Business History 
To listen to the show early and ad free, sign up for Pushkin+

Helen Pearson is the author of the book &ldquo;Beyond Belief: How Evidence Shows What Really Works.&rdquo; Helen's problem is this: How do you get people to make important decisions based on high-quality evidence, instead of on hunches or habits?
In this episode, Helen explains:&nbsp;
<ul>
<li>How a doctor's fatal mistake sparked the evidence-based medicine movement</li>
<li>Why management is so resistant to evidence-based practices</li>
<li>How systematic reviews changed the way she works as a science journalist</li>
<li>Why global trust in science remains high &ndash; outside the US</li>
<li>What a randomized trial of pint glasses revealed about preventing violent injuries.</li>
</ul>
Check out Helen&rsquo;s book <a href="https://press.princeton.edu/books/hardcover/9780691207070/beyond-belief?srsltid=AfmBOooVaXmWw4JymbCEjP6j1gJchAmKubucnn3yzLZz7AH7s3vWnWQU" data-airgap-id="12">here</a>.&nbsp;
Connect with us:
<ul>
<li>Follow Jacob Goldstein on <a href="https://www.linkedin.com/in/jacob-goldstein-888a2441/" data-airgap-id="13">LinkedIn</a>, <a href="https://x.com/jacobgoldstein?lang=en" data-airgap-id="14">X</a> and <a href="https://www.instagram.com/jacobjgoldstein/" data-airgap-id="15">Instagram&nbsp;</a></li>
<li>Email us at <a href="mailto:problem@pushkin.fm" data-airgap-id="16">problem@pushkin.fm</a>&nbsp;</li>
<li>Follow Pushkin on <a href="https://www.instagram.com/pushkinpods/" data-airgap-id="17">Instagram</a>,<a href="https://www.linkedin.com/company/pushkin-industries/posts/?feedView=all" data-airgap-id="18"> LinkedIn</a> or <a href="https://x.com/pushkinpods?lang=en" data-airgap-id="19">X</a>&nbsp;</li>
<li>Listen to Jacob&rsquo;s other show, <a href="https://podcasts.apple.com/us/podcast/business-history/id1844409167" data-airgap-id="20">Business History&nbsp;</a></li>
<li>To listen to the show early and ad free, sign up for <a href="https://www.pushkin.fm/join-pushkin" data-airgap-id="21">Pushkin+</a></li>
</ul>

Why Doctors Use Evidence but Managers (Mostly) Don’t

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/660c6b69-11b8-4fe5-b1dd-b49800fb96bf/transcript

In 2016, Geoffrey Hinton, one of the inventors of modern AI, predicted that AI would replace radiologists within years. Ten years later, we have a shortage of radiologists. AI has yet to revolutionize the field. What happened, and what does the story of AI and radiology tell us about AI and the future of work?

Saurabh Jha is a radiologist at the University of Pennsylvania. He's written about how he uses AI in his practice, and why radiologists have been slow to adopt AI. Saurabh has also traveled to India and Nepal to understand the very different ways AI is being adopted for radiology in the developing world.

In this episode, Saurabh explains: 
Why AI still hasn't made radiologists faster or more productive
The risks of novice radiologists using AI versus the benefits to experts
Why a successful AI model would need to be nearly perfect 
How AI is being used to spot tuberculosis in India
Why diagnosing a normal scan is harder than diagnosing disease

Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram 
Email us at problem@pushkin.fm 
Follow Pushkin on Instagram, LinkedIn or X 
Listen to Jacob’s other show, Business History 
To listen to the show early and ad free, sign up for Pushkin+

In 2016, Geoffrey Hinton, one of the inventors of modern AI, predicted that AI would replace radiologists within years. Ten years later, we have a shortage of radiologists. AI has yet to revolutionize the field. What happened, and what does the story of AI and radiology tell us about AI and the future of work?
Saurabh Jha is a radiologist at the University of Pennsylvania. He's written about how he uses AI in his practice, and why radiologists have been slow to adopt AI. Saurabh has also traveled to India and Nepal to understand the very different ways AI is being adopted for radiology in the developing world.
In this episode, Saurabh explains:&nbsp;
<ul>
<li>Why AI still hasn't made radiologists faster or more productive</li>
<li>The risks of novice radiologists using AI versus the benefits to experts</li>
<li>Why a successful AI model would need to be nearly perfect&nbsp;</li>
<li>How AI is being used to spot tuberculosis in India</li>
<li>Why diagnosing a normal scan is harder than diagnosing disease</li>
</ul>
Connect with us:
<ul>
<li>Follow Jacob Goldstein on <a href="https://www.linkedin.com/in/jacob-goldstein-888a2441/" data-airgap-id="22">LinkedIn</a>, <a href="https://x.com/jacobgoldstein?lang=en" data-airgap-id="23">X</a> and <a href="https://www.instagram.com/jacobjgoldstein/" data-airgap-id="24">Instagram&nbsp;</a></li>
<li>Email us at <a href="mailto:problem@pushkin.fm" data-airgap-id="25">problem@pushkin.fm</a>&nbsp;</li>
<li>Follow Pushkin on <a href="https://www.instagram.com/pushkinpods/" data-airgap-id="26">Instagram</a>,<a href="https://www.linkedin.com/company/pushkin-industries/posts/?feedView=all" data-airgap-id="27"> LinkedIn</a> or <a href="https://x.com/pushkinpods?lang=en" data-airgap-id="28">X</a>&nbsp;</li>
<li>Listen to Jacob&rsquo;s other show, <a href="https://podcasts.apple.com/us/podcast/business-history/id1844409167" data-airgap-id="29">Business History&nbsp;</a></li>
<li>To listen to the show early and ad free, sign up for <a href="https://www.pushkin.fm/join-pushkin" data-airgap-id="30">Pushkin+</a></li>
</ul>

The Job AI Was Supposed to Kill

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/92f3d715-d451-43fa-a7d6-b49500f82ed9/transcript

Using Sound Waves to Destroy Tumors

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