Last year, the FDA approved a treatment for sickle cell disease using a revolutionary new gene editing technology called CRISPR. Rachel Haurwitz conducted pioneering research on CRISPR as a graduate student. Now she’s the co-founder and CEO of Caribou Biosciences. Rachel's problem is this: How can you improve CRISPR and use it to engineer human immune cells to fight cancer? 

Last year, the FDA approved a treatment for sickle cell disease using a revolutionary new gene editing technology called CRISPR. Rachel Haurwitz conducted pioneering research on CRISPR as a graduate student. Now she’s the co-founder and CEO of Caribou Biosciences. Rachel's problem is this: How can you improve CRISPR and use it to engineer human immune cells to fight cancer?

Every week on What’s Your Problem, entrepreneurs and engineers talk about the future they’re trying to build – and the problems they have to solve to get there.

How do you take a drone delivery service you’ve built in Rwanda and make it work in North Carolina? How do you convince people to buy a house on the Internet? How do you sell thousands of dog ramps to weiner dogs all across America when a pandemic breaks the global supply chain? 

Hosted by former Planet Money host Jacob Goldstein, What’s Your Problem helps listeners understand the problems really smart people are trying to solve right now.

iHeartMedia is the exclusive podcast partner of Pushkin Industries.

What's Your Problem?

Fighting Cancer with CRISPR

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/cc308cac-2f96-47cc-b21e-b171010e4d31/transcript

Why has rabies invaded our nightmares for centuries? Author and veterinarian Monica Murphy tells us about the cultural history of rabies (which involves vampires and werewolves!) and how our long nightmare with the disease came to an end. Then, wildlife biologist Kathy Nelson tells us about a surprising program that works to control raccoon rabies… from the sky. Enjoy this episode from Incubation, another Pushkin podcast. 

Why has rabies invaded our nightmares for centuries? Author and veterinarian Monica Murphy tells us about the cultural history of rabies (which involves vampires and werewolves!) and how our long nightmare with the disease came to an end. Then, wildlife biologist Kathy Nelson tells us about a surprising program that works to control raccoon rabies… from the sky. Enjoy this episode from <a href="https://podcasts.apple.com/us/podcast/incubation/id1703813796">Incubation</a>, another Pushkin podcast.

Rabies: When Monsters are Real…from Incubation

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/353856cc-b3d0-4800-aabf-b219015b423f/transcript

After decades of research, gene therapy is starting to work. Shannon Boye is a professor of cellular and molecular therapeutics at the University of Florida. She is also the co-founder and chief scientific officer of Atsena Therapeutics. Shannon’s problem is this: How do you use gene therapy to cure certain forms of blindness? 

After decades of research, gene therapy is starting to work. Shannon Boye is a professor of cellular and molecular therapeutics at the University of Florida. She is also the co-founder and chief scientific officer of Atsena Therapeutics. Shannon’s problem is this: How do you use gene therapy to cure certain forms of blindness?

Using Gene Therapy to Help the Blind See

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/caf0e197-0987-433f-9c46-b204012678e1/transcript

*Or at least, sort of bringing back mammoths and dodos.

Beth Shapiro is the chief scientific officer at Colossal Biosciences and the author of How to Clone a Mammoth: The Science of De-Extinction. Beth's problem is this: How do you use the tools of modern biology – and hundreds of millions of dollars – to bring back species that have been extinct for centuries? And on another level, Beth’s problem is explaining to the world what it really means (and doesn’t mean) to bring back an extinct species.

*Or at least, sort of bringing back mammoths and dodos. Beth Shapiro is the chief scientific officer at Colossal Biosciences and the author of How to Clone a Mammoth: The Science of De-Extinction. Beth's problem is this: How do you use the tools of modern biology – and hundreds of millions of dollars – to bring back species that have been extinct for centuries? And on another level, Beth’s problem is explaining to the world what it really means (and doesn’t mean) to bring back an extinct species.

Bringing Back Mammoths and Dodos*

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/cbac9034-e6fe-47cc-bd0b-b1fd01248893/transcript

Fighting Cancer with CRISPR

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