College Football Week 6 is packed with matchups that could confirm everything we think we know about the 2026 season, or force us to reconsider. We preview Georgia-Alabama in Tuscaloosa, where two SEC heavyweights face a major test, and Texas-Oklahoma in a Red River rivalry featuring plenty of questions about both offenses.

Can Indiana keep rolling against an improved Nebraska team? Is UCLA ready to challenge Oregon in Eugene, especially with questions surrounding the Ducks' quarterback situation? And what happens when USC travels to Penn State for a White Out with both teams looking for answers? We break down the matchups, debate what matters most, and make our picks against the spread.

Plus, we run through more than 20 games across the weekend, including Texas A&M-Missouri, LSU-Kentucky, Ole Miss-Vanderbilt, Iowa-Washington, Florida State-Louisville, and Iowa State-BYU. We've also got our Quad Fathers picks, under-the-radar games, locks of the week, and the Window of Opportunity.

Don't forget to enter Run The Board this week for a chance to win a $500 gift card to Bass Pro Shops!