Patrick opens with a heartfelt exchange about a daughter’s efforts to help her father, who has dementia, return to faith before his final days. He offers practical advice on confession and shares encouragement rooted in Catholic teaching. Throughout the show, Patrick responds to questions about the morality of stem cell therapy, respectfully disposing of religious items, and supporting prisoners’ spiritual needs, all while maintaining a tone of genuine understanding. He addresses timely issues such as campus controversies, academic integrity, freedom of speech in schools, and challenges facing today’s youth. Patrick also gives thoughtful guidance to a parent whose teenager is experiencing young love, emphasizing virtue and healthy boundaries. As the episode wraps up, Patrick encourages listeners to join in prayer and expresses gratitude for the supportive community that gathers on The Patrick Madrid Show.

• Patrick continues his conversation with Jodi from the end of the last hour. She’s asking for advice on how to talk to her father, who is suffering for Alzheimer’s, about the faith (00:24)
• Steven - What is the Catholic Church's position on getting stem cell therapy from animals. (10:32)
• Kay (email) - What should I do with old copies of Magnificat? (13:06)
• Rae - My husband died from Alzheimer’s and I was worried about his soul. While he was declining, we found a small Bible. I knew he was trying to make things right with God. (14:48)
• Star Harvard business professor stripped of tenure, fired for manipulating data in studies on dishonesty (19:43)
• Supreme Court declines case on student's 'only two genders' T-shirt (26:45)
• Email – Our 14-year-old has a secret girlfriend, which is against our rules. What should we do? (35:11)
• Gary – I don’t understand the bible story about the servant who works a full day and then has to keep working (43:05)