Patrick discusses the real presence of Christ in the Eucharist and the differences between Catholicism and Protestant denominations. He also addresses the sensitive topic of priests or laypeople being in romantic relationships while striving to live celibate lives. Later, a caller seeks advice on how to approach his daughter's non-Catholic wedding, and Patrick draws parallels to the biblical story of St. John the Baptist.

• Don - My 6-year-old son told me that he has mortal sin and needs to go to confession. Should I get him his sacraments early because of this?
• Katie - Can a priest perform a sacrament in the state of mortal sin? (09:41)
• Diana - What makes us not in communion with other denominations like Lutheranism and other Protestants that believe in the real presence of Jesus in the Eucharist?
• Tony - I want to give a congratulations speech at my daughter’s wedding, who I disagree with who she is marrying. What should I say?
• Wilma - Is it okay to donate your body for science? (36:58)
• Ruben - I got a Franciscan Rosary with 7 decades and was wondering if it is okay to pray that instead of the normal rosary?
• Pete - I just had a total knee replacement. is that okay since I lost my knee?