Dr. Mills dives deep into the surgical side of Peyronie's disease with Professor Matt Ziegelman from the Mayo Clinic, one of the most renowned Peyronie's surgeons in the country. Building on previous episodes covering the disease's natural history and treatments, this conversation explores the intricate surgical options — including the highly complex plaque excision and graft procedure, which requires essentially disassembling and reassembling the penis to correct the condition. Whether you're a patient weighing your options or just curious about some of the most delicate surgery in all of medicine, this is a must-listen.

Dr. Mills dives deep into the surgical side of Peyronie's disease with Professor Matt Ziegelman from the Mayo Clinic, one of the most renowned Peyronie's surgeons in the country. Building on previous episodes covering the disease's natural history and treatments, this conversation explores the intricate surgical options &mdash; including the highly complex plaque excision and graft procedure, which requires essentially disassembling and reassembling the penis to correct the condition. Whether you're a patient weighing your options or just curious about some of the most delicate surgery in all of medicine, this is a must-listen.

As Director of The Men’s Clinic at UCLA, Dr. Jesse Mills has spent his career helping men understand their bodies, their hormones, and their health. Now he’s bringing that expertise to The Male Room — a podcast where data-driven medicine meets common sense. Each episode separates fact from hype, science from snake oil, and gives men the tools to live longer, stronger, and happier lives. With candor, humor, and real-world experience from the exam room and the operating room, Dr. Mills breaks down the latest health headlines, dissects trends, and explains what actually works — and what doesn’t. Smart, straightforward, and entertaining, The Male Room is the show that helps men take charge of their health without the jargon.

As Director of The Men&rsquo;s Clinic at UCLA, Dr. Jesse Mills has spent his career helping men understand their bodies, their hormones, and their health. Now he&rsquo;s bringing that expertise to The Male Room &mdash; a podcast where data-driven medicine meets common sense. Each episode separates fact from hype, science from snake oil, and gives men the tools to live longer, stronger, and happier lives. With candor, humor, and real-world experience from the exam room and the operating room, Dr. Mills breaks down the latest health headlines, dissects trends, and explains what actually works &mdash; and what doesn&rsquo;t. Smart, straightforward, and entertaining, The Male Room is the show that helps men take charge of their health without the jargon.

The Male Room with Dr. Jesse Mills

Peyronie’s Disease Surgery: What Patients Should Know

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/73950cf3-28cf-46d0-a8d5-b478017887f2/transcript

On Part 2 of our prostate cancer series, Dr. Mills welcomes back UCLA urologic oncologist Dr. Wayne Brisbane to walk listeners through what happens after a PSA bump — touching on how doctors use prostate MRI, biomarkers, and shared decision-making to determine who really needs a biopsy. Dr. Brisbane demystifies the MRI experience (yes, the loud, tight tube), explains what those 1–5 “PIRADS” scores actually mean, and breaks down modern biopsy options—including why the transperineal approach can lower infection risk. Then it’s on decoding Gleason scores, grade groups, and “risk stratification”— and explaining why, for many men, this is a highly treatable, often curable disease when caught early. (Originally aired February 24, 2026)

On Part 2 of our prostate cancer series, Dr. Mills welcomes back UCLA urologic oncologist Dr. Wayne Brisbane to walk listeners through what happens after a PSA bump &mdash; touching on how doctors use prostate MRI, biomarkers, and shared decision-making to determine who really needs a biopsy. Dr. Brisbane demystifies the MRI experience (yes, the loud, tight tube), explains what those 1&ndash;5 &ldquo;PIRADS&rdquo; scores actually mean, and breaks down modern biopsy options&mdash;including why the transperineal approach can lower infection risk. Then it&rsquo;s on decoding Gleason scores, grade groups, and &ldquo;risk stratification&rdquo;&mdash; and explaining why, for many men, this is a highly treatable, often curable disease when caught early. (Originally aired February 24, 2026)

Prostate Cancer Awareness Month (Part 2): Diagnosing Without the Panic

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/49399c16-9266-409f-b1bc-b4b901322e86/transcript

Does stress literally break your balls? Dr. Jesse Mills is joined by urologist and men’s health specialist Dr. Susan MacDonald to break down the many causes of testicular and scrotal pain, from infections and pelvic floor dysfunction to chronic nerve pain. They explain why imaging doesn’t always reveal the source, how constipation and stress can contribute to symptoms, and why pelvic floor physical therapy may be an important part of treatment. Plus, Dr. MacDonald explains spermatic cord denervation, a surgical option that can offer relief for some men living with chronic testicular pain.

Follow Dr. MacDonald here for more information on chronic pain: @DrSusanMacDonald

More information about the Pelvic Health and Rehabilitation Center can be found here: https://www.youtube.com/@PelvicHealth

Does stress literally break your balls? Dr. Jesse Mills is joined by urologist and men&rsquo;s health specialist Dr. Susan MacDonald to break down the many causes of testicular and scrotal pain, from infections and pelvic floor dysfunction to chronic nerve pain. They explain why imaging doesn&rsquo;t always reveal the source, how constipation and stress can contribute to symptoms, and why pelvic floor physical therapy may be an important part of treatment. Plus, Dr. MacDonald explains spermatic cord denervation, a surgical option that can offer relief for some men living with chronic testicular pain.
Follow Dr. MacDonald here for more information on chronic pain: @DrSusanMacDonald
More information about the Pelvic Health and Rehabilitation Center can be found here: https://www.youtube.com/@PelvicHealth

Balls Hurt for No Reason? Here’s What It Might Mean — And What to Do

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/1e93c743-2127-4a24-8e2f-b4c600ea29ae/transcript

With September being prostate awareness month, we're resharing our lengthy discussion with UCLA urologic oncologist and surgeon-scientist Dr. Wayne Brisbane. In our first installment, Dr. Mills tackles  the most confusing—and most important—starting point: screening. What does an “elevated PSA” actually mean, why is it controversial, and how do you avoid unnecessary panic (or unnecessary procedures) while still catching cancer early? Using a real-world “55-year-old patient journey,” they break down PSA as a prostate “thermometer,” when to repeat a test, what role MRI plays today, and how newer tools like urine biomarkers and micro-ultrasound are reshaping early detection—before the series moves on to diagnosis and treatment. (Originally aired February 17, 2026)

With September being prostate awareness month, we're resharing our lengthy discussion with UCLA urologic oncologist and surgeon-scientist Dr. Wayne Brisbane. In our first installment, Dr. Mills tackles&nbsp; the most confusing&mdash;and most important&mdash;starting point: screening. What does an &ldquo;elevated PSA&rdquo; actually mean, why is it controversial, and how do you avoid unnecessary panic (or unnecessary procedures) while still catching cancer early? Using a real-world &ldquo;55-year-old patient journey,&rdquo; they break down PSA as a prostate &ldquo;thermometer,&rdquo; when to repeat a test, what role MRI plays today, and how newer tools like urine biomarkers and micro-ultrasound are reshaping early detection&mdash;before the series moves on to diagnosis and treatment. (Originally aired February 17, 2026)

Prostate Cancer Awareness Month (Part 1): Screening Without the Scare Tactics

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/b81c5580-f2e4-4bc6-8aa1-b4b901305af8/transcript

Peyronie’s Disease Surgery: What Patients Should Know

In 1 playlist(s)

The Male Room with Dr. Jesse Mills

Social links

Follow podcast

Recent clips