Dr. Jesse Mills sits down with gastroenterologist-turned-biotech leader Dr. Josh Ofman, president of GRAIL, the company behind a groundbreaking blood test designed to detect dozens of cancers early by analyzing DNA shed by tumors. They break down how multi-cancer early detection works, who should consider testing (even before age 50), and how the technology fits into the larger—and often confusing—longevity conversation. The episode also tackles concerns about over-screening, false positives, and why waiting decades for perfect data may cost lives today.

Have a question for Dr. Mills? Send us an email at: themaleroompod@gmail.com

Dr. Jesse Mills sits down with gastroenterologist-turned-biotech leader Dr. Josh Ofman, president of GRAIL, the company behind a groundbreaking blood test designed to detect dozens of cancers early by analyzing DNA shed by tumors. They break down how multi-cancer early detection works, who should consider testing (even before age 50), and how the technology fits into the larger&mdash;and often confusing&mdash;longevity conversation. The episode also tackles concerns about over-screening, false positives, and why waiting decades for perfect data may cost lives today.
Have a question for Dr. Mills? Send us an email at: themaleroompod@gmail.com

As Director of The Men’s Clinic at UCLA, Dr. Jesse Mills has spent his career helping men understand their bodies, their hormones, and their health. Now he’s bringing that expertise to The Male Room — a podcast where data-driven medicine meets common sense. Each episode separates fact from hype, science from snake oil, and gives men the tools to live longer, stronger, and happier lives. With candor, humor, and real-world experience from the exam room and the operating room, Dr. Mills breaks down the latest health headlines, dissects trends, and explains what actually works — and what doesn’t. Smart, straightforward, and entertaining, The Male Room is the show that helps men take charge of their health without the jargon.

As Director of The Men&rsquo;s Clinic at UCLA, Dr. Jesse Mills has spent his career helping men understand their bodies, their hormones, and their health. Now he&rsquo;s bringing that expertise to The Male Room &mdash; a podcast where data-driven medicine meets common sense. Each episode separates fact from hype, science from snake oil, and gives men the tools to live longer, stronger, and happier lives. With candor, humor, and real-world experience from the exam room and the operating room, Dr. Mills breaks down the latest health headlines, dissects trends, and explains what actually works &mdash; and what doesn&rsquo;t. Smart, straightforward, and entertaining, The Male Room is the show that helps men take charge of their health without the jargon.

The Male Room with Dr. Jesse Mills

Catching Cancer Early: What’s Actually Possible Now?

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/caf0c669-2b90-47e0-b2e0-b3df0058e8f2/transcript

AD BREAK

Rock and Roll Hall of Famer Tim Commerford joins The Male Room to speak candidly about his prostate cancer journey — from the shock of diagnosis and the emotional aftermath of surgery to the hard-won strength he’s built on the other side. The Rage Against the Machine bassist opens up about masculinity, recovery, fitness, sexuality, and why men need to take their health seriously and advocate for themselves. Alongside Dr. Jesse Mills and Producer Jordan, Commerford reflects on turning fear into purpose, and how sharing his story can help save lives.

Rock and Roll Hall of Famer Tim Commerford joins The Male Room to speak candidly about his prostate cancer journey &mdash; from the shock of diagnosis and the emotional aftermath of surgery to the hard-won strength he&rsquo;s built on the other side. The Rage Against the Machine bassist opens up about masculinity, recovery, fitness, sexuality, and why men need to take their health seriously and advocate for themselves. Alongside Dr. Jesse Mills and Producer Jordan, Commerford reflects on turning fear into purpose, and how sharing his story can help save lives.

Rage Against the Machine’s Tim Commerford on His Prostate Cancer Diagnosis and Recovery

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/5c65373d-b3ae-4c37-8c82-b40900c042bc/transcript

In the third and final installment of our prostate-cancer trilogy with UCLA urologic oncologist Dr. Wayne Brisbane, Dr. Mills walks a 55-year-old patient through the modern treatment menu—active surveillance, focal therapy, surgery, and radiation—and why “having prostate cancer” doesn’t always mean “operate immediately.” Dr. Brisbane breaks down how doctors risk-stratify tumors (including what Gleason scores really mean), why PSA “ups and downs” can trigger anxiety, and how newer tools (from genomic tests to MRI-guided radiation) help personalize decisions. They also get real about side effects and recovery, from muscle-sparing prostatectomy techniques that can speed urinary control to the “sunburn in the bladder” sensations some men feel after radiation. The takeaway: treat the cancer the way it’s asking to be treated—and don’t be afraid to slow down, get second opinions, and choose the option that best matches your life.

In the third and final installment of our prostate-cancer trilogy with UCLA urologic oncologist Dr. Wayne Brisbane, Dr. Mills walks a 55-year-old patient through the modern treatment menu&mdash;active surveillance, focal therapy, surgery, and radiation&mdash;and why &ldquo;having prostate cancer&rdquo; doesn&rsquo;t always mean &ldquo;operate immediately.&rdquo; Dr. Brisbane breaks down how doctors risk-stratify tumors (including what Gleason scores really mean), why PSA &ldquo;ups and downs&rdquo; can trigger anxiety, and how newer tools (from genomic tests to MRI-guided radiation) help personalize decisions. They also get real about side effects and recovery, from muscle-sparing prostatectomy techniques that can speed urinary control to the &ldquo;sunburn in the bladder&rdquo; sensations some men feel after radiation. The takeaway: treat the cancer the way it&rsquo;s asking to be treated&mdash;and don&rsquo;t be afraid to slow down, get second opinions, and choose the option that best matches your life.

Prostate Cancer (Part 3): Surgery, Radiation, and the Reality of Side Effects

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/d2e12780-5d86-428e-b8a8-b401014f75bc/transcript

On Part 2 of our prostate cancer series, Dr. Mills welcomes back UCLA urologic oncologist Dr. Wayne Brisbane to walk listeners through what happens after a PSA bump — touching on how doctors use prostate MRI, biomarkers, and shared decision-making to determine who really needs a biopsy. Dr. Brisbane demystifies the MRI experience (yes, the loud, tight tube), explains what those 1–5 “PIRADS” scores actually mean, and breaks down modern biopsy options—including why the transperineal approach can lower infection risk. Then it’s on decoding Gleason scores, grade groups, and “risk stratification”— and explaining why, for many men, this is a highly treatable, often curable disease when caught early.

On Part 2 of our prostate cancer series, Dr. Mills welcomes back UCLA urologic oncologist Dr. Wayne Brisbane to walk listeners through what happens after a PSA bump &mdash; touching on how doctors use prostate MRI, biomarkers, and shared decision-making to determine who really needs a biopsy. Dr. Brisbane demystifies the MRI experience (yes, the loud, tight tube), explains what those 1&ndash;5 &ldquo;PIRADS&rdquo; scores actually mean, and breaks down modern biopsy options&mdash;including why the transperineal approach can lower infection risk. Then it&rsquo;s on decoding Gleason scores, grade groups, and &ldquo;risk stratification&rdquo;&mdash; and explaining why, for many men, this is a highly treatable, often curable disease when caught early.

Prostate Cancer (Part 2): Diagnosing Without the Panic

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/6eb9230f-72da-47a7-96e3-b3fb0067baf2/transcript

Catching Cancer Early: What’s Actually Possible Now?

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