The O.R. is jam packed this week with some of the BIGGEST guests we’ve ever had! We start off with worlds colliding for Tanya, because Ryan Seacrest scrubs in and gives some incredible advice for some burning Ask a Guy questions, and we hear his thoughts on what Tanya should do to her new place to attract more guys.   And Dr. April Kepner herself, Sarah Drew, stops by with her Grey’s co-star Justin Bruening, to talk about their new movie, and what it was like taking their on-screen relationship to a new project. Plus, she shares some juicy behind the scenes secrets about her time on Grey’s Anatomy.