What really separates roflumilast (Zoryve) from other PDE4 inhibitors — and why does it matter for your patients with atopic dermatitis, psoriasis, or seborrheic dermatitis? In this episode, Dr. Ted Lane sits down with Dr. Chris Bunick, Associate Professor of Dermatology at Yale School of Medicine and Editor-in-Chief of Dermatology Times, for a deep dive into the biochemistry, formulation science, and clinical implications behind this breakthrough topical treatment.

In this episode, you'll learn:
Why roflumilast binds PDE4 with 200x more potency than apremilast — and 1,000x more than crisaborole
How cyclic AMP inhibition controls upstream cytokine pathways (TH1, TH2, TH17) across multiple inflammatory skin diseases
The science behind the Crotofos emulsifier — and why the right emulsifier protects the skin barrier instead of stripping ceramides
Why formulating at pH 5.5 matters for filaggrin, keratin, and barrier integrity
How the roflumilast foam is specifically engineered for scalp conditions and hair-bearing areas
What's next in topical formulation innovation — from targeted dermal delivery to longevity skincare

Whether you're a dermatologist, resident, PA, NP, or skincare enthusiast who wants to understand the why behind cutting-edge topicals, this episode is packed with clinical and scientific insight you won't find anywhere else.

🎙️ This episode is sponsored by Arcutis Biotherapeutics, maker of roflumilast cream and foam.

📧 Send your questions to: questions@scienceofskinnsummit.com

📅 Science of Skin Summit — September 19–21, Austin, TX

📅 Longevity Meeting — February 19 - 21, Scottsdale, AZ

Subscribe, leave a 5-star review, and follow Dr. Bunick's podcast: ABCDs in Dermatology.

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

What really separates roflumilast (Zoryve) from other PDE4 inhibitors &mdash; and why does it matter for your patients with atopic dermatitis, psoriasis, or seborrheic dermatitis? In this episode, Dr. Ted Lane sits down with Dr. Chris Bunick, Associate Professor of Dermatology at Yale School of Medicine and Editor-in-Chief of Dermatology Times, for a deep dive into the biochemistry, formulation science, and clinical implications behind this breakthrough topical treatment.
In this episode, you'll learn:
<ul>
<li>Why roflumilast binds PDE4 with 200x more potency than apremilast &mdash; and 1,000x more than crisaborole</li>
<li>How cyclic AMP inhibition controls upstream cytokine pathways (TH1, TH2, TH17) across multiple inflammatory skin diseases</li>
<li>The science behind the Crotofos emulsifier &mdash; and why the right emulsifier protects the skin barrier instead of stripping ceramides</li>
<li>Why formulating at pH 5.5 matters for filaggrin, keratin, and barrier integrity</li>
<li>How the roflumilast foam is specifically engineered for scalp conditions and hair-bearing areas</li>
<li>What's next in topical formulation innovation &mdash; from targeted dermal delivery to longevity skincare</li>
</ul>
Whether you're a dermatologist, resident, PA, NP, or skincare enthusiast who wants to understand the why behind cutting-edge topicals, this episode is packed with clinical and scientific insight you won't find anywhere else.
🎙️ This episode is sponsored by Arcutis Biotherapeutics, maker of roflumilast cream and foam.
📧 Send your questions to: <a href="mailto:questions@scienceofskinnsummit.com">questions@scienceofskinnsummit.com</a>
📅 Science of Skin Summit &mdash; September 19&ndash;21, Austin, TX
📅 Longevity Meeting &mdash; February 19 - 21, Scottsdale, AZ
Subscribe, leave a 5-star review, and follow Dr. Bunick's podcast: ABCDs in Dermatology.
Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

The Science of Skin is a podcast for those who want to be in-the-know about what’s trending, and what’s next in topical skincare.  Hosts  Dr. Patti Farris and Dr. Ted Lain are board certified dermatologist, recognized experts in topical skincare and co-founders of the Science of Skin Summit. In each episode, The Science of Skin will give you an insider’s view of the skincare industry.  You will hear from research scientists, formulators, and leading physician experts on how products are developed, tested, and used to treat medical and cosmetic patients.  

So, if you’re interested in a behind the scenes look at what makes the skincare industry tick, subscribe to The Science of Skin today. Thanks for listening!

 

You can slo find us on YouTube: https://www.youtube.com/@scienceofskinpodcast

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

The Science of Skin is a podcast for those who want to be in-the-know about what&rsquo;s trending, and what&rsquo;s next in topical skincare.&nbsp; Hosts &nbsp;Dr. Patti Farris and Dr. Ted Lain are board certified dermatologist, recognized experts in topical skincare and co-founders of the <a href="https://scienceofskincaresummit.com/">Science of Skin Summit</a>. In each episode, The Science of Skin will give you an insider&rsquo;s view of the skincare industry.&nbsp; You will hear from research scientists, formulators, and leading physician experts on how products are developed, tested, and used to treat medical and cosmetic patients. &nbsp;
So, if you&rsquo;re interested in a behind the scenes look at what makes the skincare industry tick, subscribe to The Science of Skin today. Thanks for listening!
&nbsp;
You can slo find us on YouTube: <a href="https://www.youtube.com/@scienceofskinpodcast">https://www.youtube.com/@scienceofskinpodcast</a>
Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

The Science of Skin

The Science of Skin is a podcast for those who want to be in-the-know about what’s trending, and what’s next in topical skincare.  Hosts  Dr. Patti Farris and Dr. Ted Lain are board certified dermatologist, recognized experts in topical skincare and co-founders of the Science of Skin Summit. In each episode, The Science of Skin will give you an insider’s view of the skincare industry.  You will hear from research scientists, formulators, and leading physician experts on how products are developed, tested, and used to treat medical and cosmetic patients.  

So, if you’re interested in a behind the scenes look at what makes the skincare industry tick, subscribe to The Science of Skin today. Thanks for listening!

You can also find us on YouTube: https://www.youtube.com/@scienceofskinpodcast

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

The Science of Skin is a podcast for those who want to be in-the-know about what&rsquo;s trending, and what&rsquo;s next in topical skincare.&nbsp; Hosts &nbsp;Dr. Patti Farris and Dr. Ted Lain are board certified dermatologist, recognized experts in topical skincare and co-founders of the <a href="https://scienceofskincaresummit.com/">Science of Skin Summit</a>. In each episode, The Science of Skin will give you an insider&rsquo;s view of the skincare industry.&nbsp; You will hear from research scientists, formulators, and leading physician experts on how products are developed, tested, and used to treat medical and cosmetic patients. &nbsp;
So, if you&rsquo;re interested in a behind the scenes look at what makes the skincare industry tick, subscribe to The Science of Skin today. Thanks for listening!
You can also find us on YouTube: <a href="https://www.youtube.com/@scienceofskinpodcast">https://www.youtube.com/@scienceofskinpodcast</a>
Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

Roflumilast vs. Crisaborole: The PDE4 Science That Changes Everything

Dr. Ted Lain sits down with board-certified pediatric dermatologist Dr. Nnenna Agim to discuss the toddler indication for roflumilast cream (Zoryve) and how non-steroidal topicals are changing the treatment landscape for atopic dermatitis, psoriasis, and seborrheic dermatitis in children.

In this episode of the Science of Skin Podcast, Dr. Agim shares her real-world clinical experience using roflumilast cream 0.05% (ages 2-5) and 0.15% (ages 6+) as a steroid-sparing alternative for pediatric eczema, explaining why more families are requesting non-steroidal options from the start of treatment. The conversation covers:
Why roflumilast (Zoryve) is safe to use on any body surface, including the face and skin folds
Managing parent expectations and proper dosing to avoid overuse
The importance of pairing roflumilast with ceramide-rich, fragrance-free moisturizers like CeraVe, La Roche-Posay, and Vaseline
How roflumilast compares to crisaborole (Eucrisa) and topical corticosteroids in tolerability
Treating psoriasis and seborrheic dermatitis in children with roflumilast foam and cream
Skin barrier repair, ceramide production, and the role of the acid mantle in atopic dermatitis
Caring for textured hair and scalp conditions in pediatric patients
Real patient outcomes and quality-of-life improvements with Zoryve

This episode is sponsored by Arcutis Biotherapeutics and is part of an ongoing series exploring roflumilast formulation science. Don't miss the related episode on roflumilast's formulation with Dr. Chris Bunick.

Learn more about the Science of Skin Summit (Austin, TX) and the new Science of Skin Longevity Summit (Scottsdale, AZ, Feb 2027) at scienceofskinsummit.com.

🔔 Subscribe and leave a 5-star rating to support the show!

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

Dr. Ted Lain sits down with board-certified pediatric dermatologist Dr. Nnenna Agim to discuss the toddler indication for roflumilast cream (Zoryve) and how non-steroidal topicals are changing the treatment landscape for atopic dermatitis, psoriasis, and seborrheic dermatitis in children.
In this episode of the Science of Skin Podcast, Dr. Agim shares her real-world clinical experience using roflumilast cream 0.05% (ages 2-5) and 0.15% (ages 6+) as a steroid-sparing alternative for pediatric eczema, explaining why more families are requesting non-steroidal options from the start of treatment. The conversation covers:
<ul>
<li>Why roflumilast (Zoryve) is safe to use on any body surface, including the face and skin folds</li>
<li>Managing parent expectations and proper dosing to avoid overuse</li>
<li>The importance of pairing roflumilast with ceramide-rich, fragrance-free moisturizers like CeraVe, La Roche-Posay, and Vaseline</li>
<li>How roflumilast compares to crisaborole (Eucrisa) and topical corticosteroids in tolerability</li>
<li>Treating psoriasis and seborrheic dermatitis in children with roflumilast foam and cream</li>
<li>Skin barrier repair, ceramide production, and the role of the acid mantle in atopic dermatitis</li>
<li>Caring for textured hair and scalp conditions in pediatric patients</li>
<li>Real patient outcomes and quality-of-life improvements with Zoryve</li>
</ul>
This episode is sponsored by Arcutis Biotherapeutics and is part of an ongoing series exploring roflumilast formulation science. Don't miss the related episode on roflumilast's formulation with Dr. Chris Bunick.
Learn more about the Science of Skin Summit (Austin, TX) and the new Science of Skin Longevity Summit (Scottsdale, AZ, Feb 2027) at <a href="https://scienceofskinsummit.com/">scienceofskinsummit.com</a>.
🔔 Subscribe and leave a 5-star rating to support the show!
Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

Roflumilast Cream for Toddler Eczema, Psoriasis & Seborrheic Dermatitis

In this episode of the Science of Skin podcast, board-certified dermatologist Dr. Patti Farris sits down with Golden Follicle Award winner and hair restoration surgery pioneer Dr. Nicole Rogers to break down everything you need to know about hair loss treatment — from trending social media remedies to cutting-edge clinical trials.

Whether you're experiencing male pattern baldness, female pattern hair loss, postpartum shedding, or hair thinning from GLP-1 weight loss drugs, this episode covers it all. Dr. Rogers shares her expert framework for building a personalized hair loss treatment plan and explains exactly when to move from over-the-counter solutions to prescription therapies.

Topics covered include:
Rosemary oil, pumpkin seed oil & nutraceuticals — do they actually work?
Oral minoxidil vs. topical minoxidil — what the latest research shows
Extended-release oral minoxidil (Veridermix) — the next FDA-approved hair loss drug?
Finasteride and dutasteride for men and women — dosing, safety, and the truth about post-finasteride syndrome
Spironolactone for pre-menopausal women with hair loss
Topical finasteride and dutasteride via compounding pharmacy
Low-level laser/red light therapy (LLLT) for hair growth — what the science really says
PRP (platelet-rich plasma) injections — when they help and when they're overhyped
Exosomes for hair loss — promise vs. FDA concerns
PP405 and stem cell activation — the groundbreaking new molecule in clinical trials
FUE vs. FUT hair transplant surgery — what's right for you
No-shave FUE — the emerging frontier in hair restoration
Hair transplants for women — why strip harvesting remains the gold standard

If you're searching for answers on androgenetic alopecia, alopecia areata, telogen effluvium, scalp health, DHT blockers, hair regrowth treatments, or the best dermatologist-recommended solutions for thinning hair, this is the episode you've been waiting for. Dr. Rogers brings decades of clinical expertise, peer-reviewed research, and real patient outcomes to help you navigate the overwhelming world of hair loss — with science, not social media hype.

🎙️ Subscribe, leave a review, and share with anyone on their hair loss journey. New episodes available on Apple Podcasts and Spotify.

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

In this episode of the Science of Skin podcast, board-certified dermatologist Dr. Patti Farris sits down with Golden Follicle Award winner and hair restoration surgery pioneer Dr. Nicole Rogers to break down everything you need to know about hair loss treatment &mdash; from trending social media remedies to cutting-edge clinical trials.
Whether you're experiencing male pattern baldness, female pattern hair loss, postpartum shedding, or hair thinning from GLP-1 weight loss drugs, this episode covers it all. Dr. Rogers shares her expert framework for building a personalized hair loss treatment plan and explains exactly when to move from over-the-counter solutions to prescription therapies.
Topics covered include:
<ul>
<li>Rosemary oil, pumpkin seed oil &amp; nutraceuticals &mdash; do they actually work?</li>
<li>Oral minoxidil vs. topical minoxidil &mdash; what the latest research shows</li>
<li>Extended-release oral minoxidil (Veridermix) &mdash; the next FDA-approved hair loss drug?</li>
<li>Finasteride and dutasteride for men and women &mdash; dosing, safety, and the truth about post-finasteride syndrome</li>
<li>Spironolactone for pre-menopausal women with hair loss</li>
<li>Topical finasteride and dutasteride via compounding pharmacy</li>
<li>Low-level laser/red light therapy (LLLT) for hair growth &mdash; what the science really says</li>
<li>PRP (platelet-rich plasma) injections &mdash; when they help and when they're overhyped</li>
<li>Exosomes for hair loss &mdash; promise vs. FDA concerns</li>
<li>PP405 and stem cell activation &mdash; the groundbreaking new molecule in clinical trials</li>
<li>FUE vs. FUT hair transplant surgery &mdash; what's right for you</li>
<li>No-shave FUE &mdash; the emerging frontier in hair restoration</li>
<li>Hair transplants for women &mdash; why strip harvesting remains the gold standard</li>
</ul>
If you're searching for answers on androgenetic alopecia, alopecia areata, telogen effluvium, scalp health, DHT blockers, hair regrowth treatments, or the best dermatologist-recommended solutions for thinning hair, this is the episode you've been waiting for. Dr. Rogers brings decades of clinical expertise, peer-reviewed research, and real patient outcomes to help you navigate the overwhelming world of hair loss &mdash; with science, not social media hype.
🎙️ Subscribe, leave a review, and share with anyone on their hair loss journey. New episodes available on Apple Podcasts and Spotify.
Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

Hair Loss Treatments: Dr. Nicole Rogers on What Actually Works

Are you a dermatologist curious about clinical research — or a seasoned trialist looking to reignite your passion? In this episode of the Science of Skin Podcast, Dr. Ted Lane (Austin, TX) sits down with Dr. Jason Hawkes, Chief Scientific Officer at Oregon Medical Research Center, to pull back the curtain on what it really means to build a career in dermatology clinical trials.

From navigating the growing complexity of modern trial protocols to reframing the pharma-physician relationship, Ted and Jason share candid insights that only experienced clinical trialists can offer. They discuss how running trials makes you a sharper diagnostician, why medical dermatology remains one of the most rewarding specialties, and how industry partnerships open unexpected academic and commercial doors.

You'll also hear their honest takes on mentorship — including the must-read JAMA article Mentorship Malpractice — and why thinking of your career as a lattice, not a ladder may be the most liberating shift you can make.

Whether you're five years into practice or just starting out, this episode is packed with hard-won wisdom on building a meaningful, intellectually stimulating career in dermatology.

📩 Questions or future episode ideas? Email: questions@scienceofskinpodcast.com

Topics Covered:
How clinical trials combat physician burnout
The real motivations behind patient participation in trials
How to interpret clinical data like a trialist
Navigating the evolving complexity of trial conduct
Building industry relationships the right way
The importance of mentorship in dermatology research
Career advice: "lattice, not a ladder"

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

Are you a dermatologist curious about clinical research &mdash; or a seasoned trialist looking to reignite your passion? In this episode of the Science of Skin Podcast, Dr. Ted Lane (Austin, TX) sits down with Dr. Jason Hawkes, Chief Scientific Officer at Oregon Medical Research Center, to pull back the curtain on what it really means to build a career in dermatology clinical trials.
From navigating the growing complexity of modern trial protocols to reframing the pharma-physician relationship, Ted and Jason share candid insights that only experienced clinical trialists can offer. They discuss how running trials makes you a sharper diagnostician, why medical dermatology remains one of the most rewarding specialties, and how industry partnerships open unexpected academic and commercial doors.
You'll also hear their honest takes on mentorship &mdash; including the must-read JAMA article Mentorship Malpractice &mdash; and why thinking of your career as a lattice, not a ladder may be the most liberating shift you can make.
Whether you're five years into practice or just starting out, this episode is packed with hard-won wisdom on building a meaningful, intellectually stimulating career in dermatology.
📩 Questions or future episode ideas? Email: <a href="mailto:questions@scienceofskinpodcast.com">questions@scienceofskinpodcast.com</a>
Topics Covered:
<ul>
<li>How clinical trials combat physician burnout</li>
<li>The real motivations behind patient participation in trials</li>
<li>How to interpret clinical data like a trialist</li>
<li>Navigating the evolving complexity of trial conduct</li>
<li>Building industry relationships the right way</li>
<li>The importance of mentorship in dermatology research</li>
<li>Career advice: "lattice, not a ladder"</li>
</ul>
Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

Roflumilast vs. Crisaborole: The PDE4 Science That Changes Everything

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