Sam Quinones is a distinguished journalist and author who has reported on America's opioid crisis for over a decade. His 2015 book, Dreamland, examined the spread of prescription opioids and then heroin across the country. His new book, The Least of Us, focuses on the spread of fentanyl and P2P methamphetamine, and their devastating impact on people and communities. We discussed all of this, including the evolution in illicit drug networks, racial differences in drug use, Sam’s skepticism of hard reduction, and my skepticism of his policy recommendations.