Chelsea Handler is the famous comedian, author, talk show host, documentary maker and activist whose millions of fans relish her revealing and humorous stories about sex, drugs, relationships and politics. Our conversation focused, of course, on drugs: on how getting in trouble with drugs launched her career in comedy, on why she prefers marijuana to alcohol, on what she has learned from her experiences with psychedelics, on which drugs help with creative writing, and on why she considers herself a “pharmacological intuit.”