Fierce Healthcare unveiled its seventh annual Fierce 15 earlier this month, introducing the 2025 class of 15 companies bringing innovation and bold ideas to healthcare. Executive Editor Heather Landi and Senior Writer Paige Minemyer sit down to chat about the evolution of the Fierce 15 project over the past seven years, how it has become more competitive and how the virtual care boom during the COVID-19 pandemic ushered in a new generation of companies. Telehealth seemed novel in 2019 but has now become mainstream. 

Paige and Heather also dive into Fierce Healthcare’s collaboration this year with the New York Stock Exchange and Senior Writer Anastassia Gliadkovskaya’s interview with NYSE TV on the trading floor. What companies will make the list next year and what trends will define the market? Stay tuned next year for the 2026 class of the Fierce 15. 

To learn more about the topics in this episode: 
Fierce Healthcare's Fierce 15 of 2025
Fierce Healthcare's Anastassia Gliadkovskaya presents Fierce 15 at NYSE
Fierce Healthcare's Fierce 15 of 2024
Fierce Healthcare's Fierce 15 of 2023

This episode is sponsored by Optum Rx. Learn more.

Fierce Healthcare unveiled its seventh annual Fierce 15 earlier this month, introducing the 2025 class of 15 companies bringing innovation and bold ideas to healthcare. Executive Editor Heather Landi and Senior Writer Paige Minemyer sit down to chat about the evolution of the Fierce 15 project over the past seven years, how it has become more competitive and how the virtual care boom during the COVID-19 pandemic ushered in a new generation of companies. Telehealth seemed novel in 2019 but has now become mainstream.&nbsp;
Paige and Heather also dive into Fierce Healthcare&rsquo;s collaboration this year with the New York Stock Exchange and Senior Writer Anastassia Gliadkovskaya&rsquo;s interview with NYSE TV on the trading floor. What companies will make the list next year and what trends will define the market? Stay tuned next year for the 2026 class of the Fierce 15.&nbsp;
To learn more about the topics in this episode:&nbsp;
<ul>
<li><a href="https://www.fiercehealthcare.com/special-reports/fierce-healthcares-fierce-15-2025">Fierce Healthcare's Fierce 15 of 2025</a></li>
<li><a href="https://www.fiercehealthcare.com/health-tech/fierce-healthcares-anastassia-gliadkovskaya-presents-fierce-15-nyse">Fierce Healthcare's Anastassia Gliadkovskaya presents Fierce 15 at NYSE</a></li>
<li><a href="https://www.fiercehealthcare.com/special-reports/fierce-healthcares-fierce-15-2024">Fierce Healthcare's Fierce 15 of 2024</a></li>
<li><a href="https://Fierce Healthcare's Fierce 15 of 2023">Fierce Healthcare's Fierce 15 of 2023</a></li>
</ul>
This episode is sponsored by Optum Rx. <a href="https://ad.doubleclick.net/ddm/clk/608177016;413236643;d;gdpr=$%7BGDPR%7D;gdpr_consent=$%7BGDPR_CONSENT_755%7D">Learn more</a>.

Podnosis: the pulse of the healthcare industry. Every week, journalists from Fierce Healthcare dive into some of the industry’s biggest trends. We talk to the experts about what’s important now so you can prep for the future. Hear about all things healthcare, from physician practices to hospital chains and insurance giants—and those that mix all three—plus the tech they use, disruptors looking to compete and people moving the sector forward. Follow Podnosis on Apple Podcasts, Spotify, Amazon or wherever you get your podcasts.

Podnosis: the pulse of the healthcare industry. Every week, journalists from Fierce Healthcare dive into some of the industry’s biggest trends. We talk to the experts about what’s important now so you can prep for the future. Hear about all things healthcare, from physician practices to hospital chains and insurance giants—and those that mix all three—plus the tech they use, disruptors looking to compete and people moving the sector forward. Follow Podnosis on Apple Podcasts, Spotify, Amazon or wherever you get your podcasts.

Podnosis

Podnosis: the pulse of the healthcare industry. Every week, journalists from Fierce Healthcare dive into some of the industry’s biggest trends. We talk to the experts about what’s important now so you can prep for the future. Hear about all things healthcare, from physician practices to hospital chains and insurance giants—and those that mix all three—plus the tech they use, disruptors looking to compete and people moving the sector forward. Follow Podnosis on Apple Podcasts, Spotify, Amazon or wherever you get your podcasts.

Fierce 15 of 2025: A breakdown

Dual-eligible beneficiaries are among the most expensive and complex patients out there. The costliest 5% of dual-eligibles drive more than 40% of Medicare spend. But addressing their medical, behavioral and social needs is far from simple. Community-based organizations could use extra help. 

From coordinating billing to telemedicine to care navigation, Pair Team claims to offer just that. It does so through California's Medi-Cal Community Care Hubs model. To break this down, Senior Writer Anastassia Gliadkovskaya talks to Nate Favini, Pair Team’s chief medical officer.  

Then, she connects with Christian Curby, executive director of Turlock Gospel Mission, a nonprofit in California’s Central Valley partnering with Pair Team to support people without housing. 

To learn more about the topics in this episode: 
Policy report on improving care for disadvantaged youth in LA stresses collaboration
Socially Determined's platform now stratifies social risks for minors
New Unite Us-driven payments pilot to reimburse social service organizations in Brooklyn

This episode is sponsored by Optum Rx. Learn more.

Dual-eligible beneficiaries are among the most expensive and complex patients out there. The costliest 5% of dual-eligibles <a href="https://www.medpac.gov/wp-content/uploads/import_data/scrape_files/docs/default-source/reports/June04_ch3.pdf">drive </a>more than 40% of Medicare spend. But addressing their medical, behavioral and social needs is far from simple. Community-based organizations could use extra help.&nbsp;
From coordinating billing to telemedicine to care navigation, Pair Team claims to offer just that. It does so through California's Medi-Cal Community Care Hubs model. To break this down, Senior Writer Anastassia Gliadkovskaya talks to Nate Favini, Pair Team&rsquo;s chief medical officer.&nbsp;&nbsp;
Then, she connects with Christian Curby, executive director of Turlock Gospel Mission, a nonprofit in California&rsquo;s Central Valley partnering with Pair Team to support people without housing.&nbsp;
To learn more about the topics in this episode:&nbsp;
<ul>
<li><a href="https://www.fiercehealthcare.com/providers/la-care-health-plan-childrens-hospital-la-team-new-policy-report">Policy report on improving care for disadvantaged youth in LA stresses collaboration</a></li>
<li><a href="https://www.fiercehealthcare.com/health-tech/socially-determineds-platform-now-stratifies-social-risk-minors">Socially Determined's platform now stratifies social risks for minors</a></li>
<li><a href="https://www.fiercehealthcare.com/health-tech/new-unite-us-driven-payments-solution-social-service-organizations-brooklyn">New Unite Us-driven payments pilot to reimburse social service organizations in Brooklyn</a></li>
</ul>
This episode is sponsored by Optum Rx. <a href="https://ad.doubleclick.net/ddm/clk/608177016;413236643;d;gdpr=$%7BGDPR%7D;gdpr_consent=$%7BGDPR_CONSENT_755%7D">Learn more</a>.

Caring for high-need, high-cost populations in California

In a sponsored episode of Podnosis, host Chris Hayden speaks with Dr. Steven O’Day, chief medical officer at Agenus, about the latest advancements in immunotherapy. With more than 30 years of experience in oncology, O’Day discusses how immunotherapy is changing cancer treatment and providing new hope where traditional methods, such as chemotherapy and radiation, often fall short.

Unlike conventional treatments that directly attack cancer cells, immunotherapy strengthens the body’s immune system—particularly T-cells—to recognize and destroy cancer. While this approach has led to significant breakthroughs in treating melanoma, challenges remain in tackling “cold” tumors, such as colorectal cancer, which the immune system struggles to identify.

Agenus is working to address this issue with its experimental therapies, botensilimab and balstilimab. The treatments aim to activate and sustain the immune response, showing promising results across multiple hard-to-treat cancers.

What’s next for immunotherapy? O’Day believes the field is entering a second revolution, with the potential to expand life-saving treatments to a broader range of cancers.

Listen to the full conversation on the latest episode of Podnosis.

In a sponsored episode of Podnosis, host Chris Hayden speaks with Dr. Steven O&rsquo;Day, chief medical officer at Agenus, about the latest advancements in immunotherapy. With more than 30 years of experience in oncology, O&rsquo;Day discusses how immunotherapy is changing cancer treatment and providing new hope where traditional methods, such as chemotherapy and radiation, often fall short.
Unlike conventional treatments that directly attack cancer cells, immunotherapy strengthens the body&rsquo;s immune system&mdash;particularly T-cells&mdash;to recognize and destroy cancer. While this approach has led to significant breakthroughs in treating melanoma, challenges remain in tackling &ldquo;cold&rdquo; tumors, such as colorectal cancer, which the immune system struggles to identify.
Agenus is working to address this issue with its experimental therapies, botensilimab and balstilimab. The treatments aim to activate and sustain the immune response, showing promising results across multiple hard-to-treat cancers.
What&rsquo;s next for immunotherapy? O&rsquo;Day believes the field is entering a second revolution, with the potential to expand life-saving treatments to a broader range of cancers.
Listen to the full conversation on the latest episode of Podnosis.

New therapies aim to expand the benefits of immunotherapy to more cancer patients

The future of immunotherapy: a game-changer in cancer treatment (Sponsored)

It’s no secret that health insurance is among the most complex parts of healthcare. With many parties involved, and evolving approaches to plan design, patients today are often confused and frustrated by their billing experience. 

Some health tech companies, like Inbox Health, help providers communicate more proactively with patients about what they might owe and what repayment options are available to them. To explain the current trends in patient billing, senior writer Anastassia Gliadkovskaya chats with Inbox Health’s co-founder and CEO Blake Walker. 

To learn more about the topics in this episode: 


Consumer Financial Protection Bureau shake-up leaves medical debt reform in limbo


Why one New York health system stopped suing its patients


Federal watchdog warns medical debt collectors off illegal tactics 

It&rsquo;s no secret that health insurance is among the most complex parts of healthcare. With many parties involved, and evolving approaches to plan design, patients today are often confused and frustrated by their billing experience.&nbsp;
Some health tech companies, like Inbox Health, help providers communicate more proactively with patients about what they might owe and what repayment options are available to them. To explain the current trends in patient billing, senior writer Anastassia Gliadkovskaya chats with Inbox Health&rsquo;s co-founder and CEO Blake Walker.&nbsp;
To learn more about the topics in this episode:&nbsp;
<ul>
<li>
<a href="https://www.fiercehealthcare.com/regulatory/consumer-financial-protection-bureau-shakeup-leaves-medical-debt-reform-limbo">Consumer Financial Protection Bureau shake-up leaves medical debt reform in limbo</a>
</li>
<li>
<a href="https://www.fiercehealthcare.com/providers/why-one-new-york-health-system-stopped-suing-its-patients">Why one New York health system stopped suing its patients</a>
</li>
<li>
<a href="https://www.fiercehealthcare.com/finance/federal-watchdog-warns-medical-debt-collectors-illegal-tactics">Federal watchdog warns medical debt collectors off illegal tactics</a>&nbsp;
</li>
</ul>

Fierce 15 of 2025: A breakdown

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