Dr. Gabrielle Lyon doesn’t just talk about strength—she reframes it, revealing how building muscle is a daily practice of resilience, clarity, and long-term health.

Jay sits down with Dr. Gabrielle Lyon for a conversation that shifts how we think about health, strength, and aging. What starts as a conversation about fitness quickly becomes something deeper: our responsibility to our future selves. Jay shares his own journey with exercise, mindset, and consistency, while Gabrielle challenges long-held beliefs around weight loss, diet culture, and why so many people feel exhausted, stuck, or confused about their health..

Together, they unpack why muscle is far more than an aesthetic goal, it’s a metabolic organ that influences brain health, longevity, hormones, confidence, and disease prevention. Gabrielle breaks down why weight loss alone can backfire, how being “skinny fat” puts people at real risk, and why muscle loss may be linked to diabetes, Alzheimer’s, and chronic fatigue. Jay bridges the science to everyday life, digging into practical questions about protein, resistance training, walking, cardio, fasting, supplements, and how even small actions, like pushups or cold exposure, can create powerful mental shifts.

In this interview, you'll learn:

How to Build Muscle for Longevity, Not Just Appearance

How to Stop Chasing Weight Loss and Start Building Strength

How to Eat Protein in a Way That Actually Builds Muscle

How to Avoid Being “Skinny Fat” and Why It Matters

How to Balance Cardio and Resistance Training for Real Results

How to Build Physical Strength That Supports Emotional Resilience

No matter your age, starting point, or past habits, it’s never too late to build strength from the inside out. Aging is inevitable, but feeling weak, stuck, or disconnected doesn’t have to be. You are allowed to become stronger, mentally and physically, one choice at a time and that choice is always available to you today.

Check out Dr. Gabrielle Lyon’s latest book, The Forever Strong PLAYBOOK, the ultimate guide for anyone who wants to feel stronger, move better, and stay energized.

To order FOREVER STRONG, visit: https://drgabriellelyon.com/forever-strong/ 

With Love and Gratitude,

Jay Shetty

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What We Discuss:

00:00 Intro

01:16 Building a Stronger, More Resilient World

02:06 Why Everything Starts With the Mind

04:12 How Building Muscle Can Shift Your Mental State

06:23 Why Unhealthy Muscle Drives Obesity

10:53 Understanding Metabolic Syndrome

13:05 Why Is Gaining Fat Easier Than Building Muscle?

16:02 A Simple Framework for Building Muscle

19:39 Muscle Mass Matters More for Long-Term Health!

25:27 Men vs. Women: Is Building Muscle Different?

28:31 Simple Ways to Test and Build Grip Strength

34:59 The Hidden Dangers of Being “Skinny Fat”

38:01 How Highly Processed Diets Damage Muscle Health

42:41 How to Use Nutrition to Stimulate Muscle Growth

47:11 How Much Protein Do We Actually Need?

51:11 The Two Ways to Stimulate Skeletal Muscle

53:45 Being Sedentary Will Kill Your Progress

57:44 Don’t Skip Meals if You Want to Gain Muscle 

59:39 Do 10,000 Steps Actually Build Muscle?

01:00:20 Do Pilates and Yoga Count as Strength Training?

01:01:11 Lifting Weights Is a Non-Negotiable

01:03:39 The Link Between Muscle Health and Fertility

01:06:58 The Only Organ System You Can Truly Control

01:09:10 Supplements That Actually Support Your Body

01:13:00 Are Protein Ice Creams Actually a Good Source of Protein?

01:17:22 How Food Companies Shape What You Believe

01:24:04 Gabrielle on Final Five

Episode Resources:

Website | https://drgabriellelyon.com/  

Instagram | https://www.instagram.com/drgabriellelyon/ 

YouTube | https://www.youtube.com/channel/UCWPQJeWz4pvccA3lIoZ7j1Q 

TikTok | https://www.tiktok.com/@drgabriellelyon  

X | https://x.com/drgabriellelyon 

Facebook | https://www.facebook.com/doctorgabriellelyon/