In this 117th episode of Sober Head Podcast, Dr. Esra Çavuşoğlu, PhD speaks with Harvard and Yale-trained physician-scientist Dr. Andrew Salzman about NAD, NMN, CD38, mitochondrial health, brain energy, and healthy aging.

Dr. Andrew Salzman is a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery, biotechnology, oncology, autoimmune diseases, and cellular therapies, and is an alumnus of Harvard Medical School, Yale University, and Columbia University. With over 170 scientific publications and more than 60 patents, he currently serves as Chief Medical Officer at Wonderfeel Biosciences, focusing on cellular health and healthy aging.

Dr. Salzman explains what NAD does inside the cell, why it is essential for energy production, DNA repair, metabolism, inflammation control, and brain function, and why NAD levels may decline with age.

The episode also explores why CD38 acts like a “drain” that breaks down NAD, why inflammation may accelerate NAD loss, whether NAD IVs really work, how NMN and NR differ, and what people should understand before taking NAD supplements. They also discuss the controversial question of NAD and cancer, why people with cancer should be cautious with supplements, and why creatine may be important not only for muscles but also for brain health and aging.

#EsraÇavuşoğlu #AyıkKafa #ElevatingLifeEvolvingHealth #Longevilab #DrAndrewSalzman

Dr. Andrew Salzman, MD
Website: https://getwonderfeel.com/experts/andrew-salzman-md/

Special thanks to T.C. Istanbul Gedik University https://www.gedik.edu.tr/en/

00:00-03:24 Introduction. 
03:24-07:14 Dr. Andrew Salzman’s Background
07:14-11:20 NA What Is NAD?
11:20-12:42 Why NAD Declines With Age
12:42-13:17 CD38: The Enzyme That Drains NAD
13:17-19:47 CD38, Ovaries and Menopause
19:47-21:03 NAD, Repair and Aging
21:03-21:58 Does NMN Feed CD38?
21:58-22:58 Do NAD IVs Work?
22:58-30:13 Why NAD Precursors Matter
30:13-40:25 NMN vs NR vs Niacin
40:25-45:18 Apigenin, Quercetin and CD38
45:18-48:06 What is NNMT and NMT pathway?
48:06-50:00 NAD and Brain Energy
50:00-53:44 NAD and Cancer Concerns
53:44-57:37 Creatine Beyond Muscle
57:37-01:04:40 Creatine and Brain Health
01:04:40-01:06:25 Gut Leak, Inflammation and Aging
01:06:25-01:08:04 Wrap up.

*About Ayık Kafa* Dr. Esra Çavuşoğlu, PhD, took her studies, starting from her personal treatment experiences and continuing with her clinical psychology education, to the next level by completing her PhD focused on Addiction. Dr. Esra in Ayık Kafa podcast discusses the world’s latest technologies, protocols, products and research in the fields of Biohacking and Longevity, while sharing first-hand information and experiences about the Disease of Addiction, as well as her latest academic studies.

*About Dr. Esra Çavuşoğlu, PhD* Longevilab’s founder, Dr. Esra, is a United States and internationally trained clinical psychologist and a certified addiction therapist in New York. She served as International Development Advisor on the Yale University Faculty of Medicine Clinical Advisory Board. She is the founder and supervisor of Gaziantep Oya Bahadır Yüksel Rehabilitation Center, Dr. Esra is the designer and implementer of the Turkey Rehabilitation Model. Dr. Esra founded the Contemporary Addiction Studies Association (ÇABAÇAD) in order to combat Turkey’s growing addiction problem.

DisclaimerThe information and statements on our YouTube Channel Sober-Head are not intended to guide individuals towards medical diagnosis and treatment.Please consult with your doctor for medical diagnostic and treatment procedures.The content is shared for informational purposes only, derived from scientific studies prepared by EMC Medya Yayıncılık Ticaret Ltd. Şti.’s researchers, consultants, and authors/scientists, as well as compilations from publicly available public