In this episode of Scientists, Unedited, Luigi Naldini, PhD, Professor of Cell and Tissue Biology and of Gene and Cell Therapy at the San Raffaele University School of Medicine and Scientific Director of the San Raffaele Telethon Institute for Gene Therapy, joins host Eirini Vamva, PhD, for a discussion on his story. Dr. Naldini, a pioneer of lentiviral vectors, reflects on the unexpected path that led him to gene therapy and helped turn a bold scientific idea into a clinical reality. He discusses the risks, setbacks, collaborations, and family support that shaped his career, as well as the future of gene therapy and why meaningful scientific progress requires persistence, teamwork, and time.