Some major developments have occurred overnight in the search for missing 84 year old Nancy Guthrie.  First, Fox News is reporting 3 people have been detained in connection with the case, while police have confirmed law enforcement activity at a nearby residence.  TMZ has revealed a third note from same author asking for more money and suggesting the crime is international.  All this, as investigators say DNA found in Guthrie home is from someone other than Nancy or those close to her.