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Well, there are around one point three million Australians that live with type two diabetes and now there's a world first trial that's going to extend and happen right here in Australia. If it's successful, it could see the reduction of insulin injections to treat advanced type two diabetes. It's a groundbreaking procedure called reset and it shows promise as a potential one off treatment. Early trial results are encouraging. Participants show substantial improvements in their blood sugar weight and overall health. Professor Elif Kinji is the co investigator of this new trial, heads up Diabetes, Austin Health and the Australian Center for Accelerating Diabetes Innovations at the University of Melbourne.

Well, there are around one point three million Australians that live with type two diabetes and now there's a world first trial that's going to extend and happen right here in Australia. If it's successful, it could see the reduction of insulin injections to treat advanced type two diabetes. It's a groundbreaking procedure called reset and it shows promise as a potential one off treatment. Early trial results are encouraging. Participants show substantial improvements in their blood sugar weight and overall health. Professor Elif Kinji is the co investigator of this new trial, heads up Diabetes, Austin Health and the Australian Center for Accelerating Diabetes Innovations at the University of Melbourne.

And I'm police to say.

And I'm police to say.

She's popped back up to have a chat with us here on afternoons.

She's popped back up to have a chat with us here on afternoons.

Thanks for your time, professor, thank you, thanks for the invitation.

Thanks for your time, professor, thank you, thanks for the invitation.

Well, we spoke back in March of twenty twenty three when you were in the beginning of working on this trial and and.

Well, we spoke back in March of twenty twenty three when you were in the beginning of working on this trial and and.

Seeing whether or not it would work.

Seeing whether or not it would work.

So can you again just tell our Afternoons listeners what the procedure is how it works. And so what you found in the two year period between when we last spoken now.

So can you again just tell our Afternoons listeners what the procedure is how it works. And so what you found in the two year period between when we last spoken now.

Yeah, thank you.

Yeah, thank you.

If you remember that that was actually the first in human clinical trial, first.

If you remember that that was actually the first in human clinical trial, first.

Time in the world. And this the reason we're having.

Time in the world. And this the reason we're having.

This conversation is because I'm presenting those results this week actually at the American Darbetes Association meeting in Chicago. So we have those results and what basically it showed is that people with diabetes had improvements in their glucose levels, insurance sensitivity, and other glue coose by marketers, and that it was a very safe procedure. And you know, it's something that is exciting, and I can tell you a little bit about how it all works. But if you recall, it was electrical pulses that controlled electrical pulses into the first part of the small test done of the duodenum, and that leads to regeneration of those cells in the duodenum in the first part.

This conversation is because I'm presenting those results this week actually at the American Darbetes Association meeting in Chicago. So we have those results and what basically it showed is that people with diabetes had improvements in their glucose levels, insurance sensitivity, and other glue coose by marketers, and that it was a very safe procedure. And you know, it's something that is exciting, and I can tell you a little bit about how it all works. But if you recall, it was electrical pulses that controlled electrical pulses into the first part of the small test done of the duodenum, and that leads to regeneration of those cells in the duodenum in the first part.

That helps improve glucose levels.

That helps improve glucose levels.

And how the research study is done is through an endoscopic procedure, so it's like similar to gastroscopy, but it's done under a general anesthetic at last about an hour and a catheterist passed by gastroentrologists into the duodenal war and that is used then to destroy those poorly functioning cells to allow the regrowth of new.

And how the research study is done is through an endoscopic procedure, so it's like similar to gastroscopy, but it's done under a general anesthetic at last about an hour and a catheterist passed by gastroentrologists into the duodenal war and that is used then to destroy those poorly functioning cells to allow the regrowth of new.

And healthy cells.

And healthy cells.

And we feel that those new cells and you know, excreet those hormones that are really important part of diabetes and glucose metabolism. So we're learning much more about the importance of duodenum in the whole picture of you know, diabetes type two diabetes in particular, So I'm excited about that. Istralia was you know, we did the first in human trials at the Austin at St Vincent and through the Austrange Center, so with a strength center for accelerating diaries innovations at the University of Melbourne and also their first and human studies are also done.

And we feel that those new cells and you know, excreet those hormones that are really important part of diabetes and glucose metabolism. So we're learning much more about the importance of duodenum in the whole picture of you know, diabetes type two diabetes in particular, So I'm excited about that. Istralia was you know, we did the first in human trials at the Austin at St Vincent and through the Austrange Center, so with a strength center for accelerating diaries innovations at the University of Melbourne and also their first and human studies are also done.

In Sydney as well.

In Sydney as well.

And now there is a follow up trial which is a sort of second trial, which is a randomized control trial which basically compares a dummy procedure versus and the actual procedure and sees whether those results you know, are happening again. And so that type of trial is really needed. Yeah, obviously for progression of this type of technology.

And now there is a follow up trial which is a sort of second trial, which is a randomized control trial which basically compares a dummy procedure versus and the actual procedure and sees whether those results you know, are happening again. And so that type of trial is really needed. Yeah, obviously for progression of this type of technology.

That's what we wait for to see the random controlled trial that's usually then the gold standard before things move move forward. I'd love you to give us a I mean, I know that this is obviously incredibly complex. There are two things that struck me about this that I wanted some clarity on. One is that everything I've read about this professor talks about advanced type two diabetes. We know that, you know, my limited understanding is that the type one diabetic is the person who is born with diabetes. Type two diabetes is the one that can develop over time. We know there are plenty of lifestyle implications of whether or not somebody will find themselves in that situation, and that you can go through a period quite prolonged where you're pre diabetic before you're diagnosed with type two diabetes. So this particular treatment, is it isolated to help those who have advanced type two diabet betes where you are insulin dependent, or can people further down the sort of diabetes path also access the potential benefit of this treatment?

That's what we wait for to see the random controlled trial that's usually then the gold standard before things move move forward. I'd love you to give us a I mean, I know that this is obviously incredibly complex. There are two things that struck me about this that I wanted some clarity on. One is that everything I've read about this professor talks about advanced type two diabetes. We know that, you know, my limited understanding is that the type one diabetic is the person who is born with diabetes. Type two diabetes is the one that can develop over time. We know there are plenty of lifestyle implications of whether or not somebody will find themselves in that situation, and that you can go through a period quite prolonged where you're pre diabetic before you're diagnosed with type two diabetes. So this particular treatment, is it isolated to help those who have advanced type two diabet betes where you are insulin dependent, or can people further down the sort of diabetes path also access the potential benefit of this treatment?

Yeah, so thank you. So, just to clarify, this is for type two.

Yeah, so thank you. So, just to clarify, this is for type two.

Diabetes only, and it's under investigation, so it's still in under clinical trials. But the clinical trials are at the moment there is still you know, it's recruiting and it is for people who have type two diabetes who are high glucose levels despite being on tablets or in injections such as in cretans, you know, the ozentbic type of medications, the ones weekly treatment. See, it's open to be real reading that in that sort of setting. And it's across Australia and other parts of the world as well, so not just in Australia but other parts of the world. And it is a randomized control trial and you can find out more information from www. Dot reset study dot com. So it's r C T study dot com. And what I think is important is that like we're finding that there are real great medications out there, as you know, there's like medications like othmpic that work using the sort of similar hormones that we think is the mechanism behind why.

Diabetes only, and it's under investigation, so it's still in under clinical trials. But the clinical trials are at the moment there is still you know, it's recruiting and it is for people who have type two diabetes who are high glucose levels despite being on tablets or in injections such as in cretans, you know, the ozentbic type of medications, the ones weekly treatment. See, it's open to be real reading that in that sort of setting. And it's across Australia and other parts of the world as well, so not just in Australia but other parts of the world. And it is a randomized control trial and you can find out more information from www. Dot reset study dot com. So it's r C T study dot com. And what I think is important is that like we're finding that there are real great medications out there, as you know, there's like medications like othmpic that work using the sort of similar hormones that we think is the mechanism behind why.

The procedures having an effect.

The procedures having an effect.

It's those hormones that are produced by the gut that is having an effect on the pancreas seeing people with type two dirbet, it's not type one because type one DIRBET is you know people it's a different process and people meet insulance.

It's those hormones that are produced by the gut that is having an effect on the pancreas seeing people with type two dirbet, it's not type one because type one DIRBET is you know people it's a different process and people meet insulance.

Is it a one off treatment do you think?

Is it a one off treatment do you think?

Or a follow up procedures or maintenance treatments expected.

Or a follow up procedures or maintenance treatments expected.

So at this stage the trial is it's a one off treatment for the trial, but we do need to follow people.

So at this stage the trial is it's a one off treatment for the trial, but we do need to follow people.

It is again it's a clinical trial.

It is again it's a clinical trial.

You know, it's not rooved or anything at this stage, but we do need to follow up to see whether that one off treatment is enough. You know, it's possible that you know, another retreatment may need to be done.

You know, it's not rooved or anything at this stage, but we do need to follow up to see whether that one off treatment is enough. You know, it's possible that you know, another retreatment may need to be done.

We don't know.

We don't know.

We don't know the answer to that, but this trial's looking at a one off treatment to see and you know how durable that response is and the effect of that is we'll be following people to see.

We don't know the answer to that, but this trial's looking at a one off treatment to see and you know how durable that response is and the effect of that is we'll be following people to see.

Yeah, because you want to see whether or not over time their benefits are sustained. And beyond blood sugar, what other health market markers did you note we're improved in the first lot of trials. Did you also see Yeah, weight and cholesterol and those other things.

Yeah, because you want to see whether or not over time their benefits are sustained. And beyond blood sugar, what other health market markers did you note we're improved in the first lot of trials. Did you also see Yeah, weight and cholesterol and those other things.

There were some favorable effects on the weight and on the lipid profile. But you know, obviously the sort of the primary outcome of that initial first pase, first phase trial was more the safety.

There were some favorable effects on the weight and on the lipid profile. But you know, obviously the sort of the primary outcome of that initial first pase, first phase trial was more the safety.

So we're more.

So we're more.

Worried about that, so we didn't, you know, necessarily have enough. You know, you've got to have the first few just to say that the preliminary results look very promising, but generally you need more people in.

Worried about that, so we didn't, you know, necessarily have enough. You know, you've got to have the first few just to say that the preliminary results look very promising, but generally you need more people in.

Trust to be sure about all of those things.

Trust to be sure about all of those things.

And that's what that second that's recruit the second trial that's on the way is looking at.

And that's what that second that's recruit the second trial that's on the way is looking at.

I just love an idea to elif you know you talked to and I'll give everybody the website again before we finish our conversation. But who is the ideal candidate for you now to be involved in this RESET clinical trial?

I just love an idea to elif you know you talked to and I'll give everybody the website again before we finish our conversation. But who is the ideal candidate for you now to be involved in this RESET clinical trial?

Or there's some specific criteria, the duration.

Or there's some specific criteria, the duration.

That they've had diabetes you already mentioned sort of the current medication regime that they might be on overall health pay a part of this.

That they've had diabetes you already mentioned sort of the current medication regime that they might be on overall health pay a part of this.

Yeah, look, I think someone who's able to undertake an endoscopy Procedureen, or anathetic who has type two diabetes on tablets all that once weekly injections like a zen pick.

Yeah, look, I think someone who's able to undertake an endoscopy Procedureen, or anathetic who has type two diabetes on tablets all that once weekly injections like a zen pick.

Preferably someone who hasn't had.

Preferably someone who hasn't had.

The diabetes for you know, really really long time or for this trial is particularly looking at. You know, see what I suppose you know, if you've had diabetes for a very long time, then there are other sort of where the pancreas doesn't work anymore.

The diabetes for you know, really really long time or for this trial is particularly looking at. You know, see what I suppose you know, if you've had diabetes for a very long time, then there are other sort of where the pancreas doesn't work anymore.

Yeah, so that can come into place.

Yeah, so that can come into place.

So ideally someone who you know may have had diabetes for you know, seven eight years or you know six seven years to look, but there were inclusion exclusion crust theory on the.

So ideally someone who you know may have had diabetes for you know, seven eight years or you know six seven years to look, but there were inclusion exclusion crust theory on the.

On the workout as well.

On the workout as well.

And look, finally, I'll say that prevention obviously of getting the diagnosis of type two diabetes, I imagine, is always preferred over a cure.

And look, finally, I'll say that prevention obviously of getting the diagnosis of type two diabetes, I imagine, is always preferred over a cure.

This is this is your life.

This is this is your life.

What lifestyle changes could people who might be pre diabetic or recently diagnosed with type two diabetes considered to help to halt the progression to see them not getting to a point where they have advanced disease.

What lifestyle changes could people who might be pre diabetic or recently diagnosed with type two diabetes considered to help to halt the progression to see them not getting to a point where they have advanced disease.

Yeah, I could not agree with you more. So prevention is the key to this. And there's some really good data that shows lifestyle things for people who have pre diabetes or her risk if they've had gestational diabetes or either you know risk factors for diabetes that you know prevention works. So even just another study that was published in The Lancet just last week that showed that if you follow up people for a long time, like twenty years, that preventative things work, so that what I'm talking about there is you know, really avoiding sort of process foods, having lots of fresh produce, lots of green vegetables, lots of vegetables, you know, avoiding you know, ultra processed foods and sugar soft drinks. You know, really increasing physical activities. I mean physical activity has benefits some you know, for every organ in the body.

Yeah, I could not agree with you more. So prevention is the key to this. And there's some really good data that shows lifestyle things for people who have pre diabetes or her risk if they've had gestational diabetes or either you know risk factors for diabetes that you know prevention works. So even just another study that was published in The Lancet just last week that showed that if you follow up people for a long time, like twenty years, that preventative things work, so that what I'm talking about there is you know, really avoiding sort of process foods, having lots of fresh produce, lots of green vegetables, lots of vegetables, you know, avoiding you know, ultra processed foods and sugar soft drinks. You know, really increasing physical activities. I mean physical activity has benefits some you know, for every organ in the body.

And could not emphasize that, you know, for me, Like really, the.

And could not emphasize that, you know, for me, Like really, the.

First thing is obviously all around prevention for people who obviously do have type two diabetes and the blood sugars are high and that you know, the medications are not working. This type of approach, you know, is another approach which could help people. Yeah, but prevention is the key to this condition.

First thing is obviously all around prevention for people who obviously do have type two diabetes and the blood sugars are high and that you know, the medications are not working. This type of approach, you know, is another approach which could help people. Yeah, but prevention is the key to this condition.

Yeah, thank you for your time this afternoon.

Yeah, thank you for your time this afternoon.

I'll say again you are looking for trial participants here for anyone who would like to learn more or to be involved, or for those who are looking for some more detailed information or to see even the scientific publications already about the trial results to this point. You can go to the website that Elift just mentioned, which is RESET study dot com and that is spelled r E c E T Study dot com.

I'll say again you are looking for trial participants here for anyone who would like to learn more or to be involved, or for those who are looking for some more detailed information or to see even the scientific publications already about the trial results to this point. You can go to the website that Elift just mentioned, which is RESET study dot com and that is spelled r E c E T Study dot com.

Promise me you'll come back on after this.

Promise me you'll come back on after this.

Next lot of trials are done and we'll see how things have unfolded for you.

Next lot of trials are done and we'll see how things have unfolded for you.

Good on, you keep up the good work.

Good on, you keep up the good work.

That's preferre elif Akinji this afternoon, just talking about that world first in being able to treat people who have advanced insulindependent diabetes. And of course the other resource that's available for people to learn more is Diabetes Australia dot com dot au.

That's preferre elif Akinji this afternoon, just talking about that world first in being able to treat people who have advanced insulindependent diabetes. And of course the other resource that's available for people to learn more is Diabetes Australia dot com dot au.

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