Dr. Victor Van Berkel lost his father to lung cancer — the deadliest cancer in the U.S., in part because it’s so difficult to detect early. That loss inspired Breath Diagnostics, a start-up using breath samples and microchip technology to identify cancer. But groundbreaking science doesn’t always translate into a sustainable business. After years of stalled leadership and mounting debt, investor Ivan Lo stepped in — buying the debt, restructuring the company and becoming CEO. When a Mayo Clinic partnership revealed they needed to fix some technical issues first, they hit pause to get it right — even if it meant going it alone for a while.

In this episode, Ben Walter and Kathleen Griffith speak with Victor and Ivan about making hard bets, the real costs and rewards of scientific startups and why leading with conviction sometimes matters more than consensus. These are The Unshakeables.