Gate Bioscience is betting that a decades-old biological mechanism could pave the way for a new class of medicines. The biotech is developing small molecules that selectively block disease-causing proteins from passing through a cellular channel called Sec61, causing them to be degraded before they can do harm.

The approach could be particularly promising for diseases of the brain, where traditional biologics face significant delivery challenges. Gate's first publicly disclosed program targets prion disease, but the company sees opportunities across inflammation, fibrosis and other therapeutic areas.

In this episode of "The Top Line," Fierce Biotech's Marissa Russo sits down with Gate co-founder and CEO Jordi Mata-Fink, Ph.D., to discuss the science behind the technology, how an expanded partnership with Eli Lilly is helping advance the platform and what's next as Gate prepares to move its first molecular gate drugs into the clinic.

To learn more about the topics in this episode: 
Gate CEO sees expanded $870M pact with Lilly as ‘vote of confidence’ in biotech’s platform

Gate Bioscience is betting that a decades-old biological mechanism could pave the way for a new class of medicines. The biotech is developing small molecules that selectively block disease-causing proteins from passing through a cellular channel called Sec61, causing them to be degraded before they can do harm.
The approach could be particularly promising for diseases of the brain, where traditional biologics face significant delivery challenges. Gate's first publicly disclosed program targets prion disease, but the company sees opportunities across inflammation, fibrosis and other therapeutic areas.
In this episode of "The Top Line," Fierce Biotech's Marissa Russo sits down with Gate co-founder and CEO Jordi Mata-Fink, Ph.D., to discuss the science behind the technology, how an expanded partnership with Eli Lilly is helping advance the platform and what's next as Gate prepares to move its first molecular gate drugs into the clinic.
To learn more about the topics in this episode:&nbsp;
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<li><a href="https://www.fiercebiotech.com/biotech/gate-secures-870m-vote-confidence-eli-lilly" data-processed-url="true">Gate CEO sees expanded $870M pact with Lilly as &lsquo;vote of confidence&rsquo; in biotech&rsquo;s platform</a></li>
</ul>

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech, and Fierce Pharma recount the latest industry trends and why they matter. We'll analyze the week's biggest business news, from mergers and marketing to drug R&D and device development. Available every Friday morning. 

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech, and Fierce Pharma recount the latest industry trends and why they matter. We'll analyze the week's biggest business news, from mergers and marketing to drug R&amp;D and device development. Available every Friday morning.&nbsp;

The Top Line

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech and Fierce Pharma recount the latest industry trends and why they matter. We’ll analyze the week’s biggest business news—from mergers and marketing to drug R&D and device development. Available every Friday morning.

 

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech and Fierce Pharma recount the latest industry trends and why they matter. We&rsquo;ll analyze the week&rsquo;s biggest business news&mdash;from mergers and marketing to drug R&amp;D and device development. Available every Friday morning.
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