At Fierce Biotech, we love a big M&A deal, but valuation does not always equal the most exciting.  

In this week's episode of "The Top Line," Fierce Biotech’s Annalee Armstrong and James Waldron discuss what they think are the best and smartest acquisitions in recent years.  

From obesity to radiopharmaceuticals, they give you the Fierce Biotech team’s thoughts on who got the best deal. 

To learn more about the topics in this episode:  
Top 10 smartest deals in biopharma

At Fierce Biotech, we love a big M&amp;A deal, but valuation does not always equal the most exciting.  
In this week's episode of "The Top Line," Fierce Biotech’s Annalee Armstrong and James Waldron discuss what they think are the best and smartest acquisitions in recent years.  
From obesity to radiopharmaceuticals, they give you the Fierce Biotech team’s thoughts on who got the best deal. 
To learn more about the topics in this episode:  
<ul>
<li><a href="https://www.fiercebiotech.com/biotech/smartest-pharma-acquisitions" data-cke-saved-href="https://www.fiercebiotech.com/biotech/smartest-pharma-acquisitions">Top 10 smartest deals in biopharma</a> </li>
</ul>

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech, and Fierce Pharma recount the latest industry trends and why they matter. We'll analyze the week's biggest business news, from mergers and marketing to drug R&D and device development. Available every Friday morning. 

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech, and Fierce Pharma recount the latest industry trends and why they matter. We'll analyze the week's biggest business news, from mergers and marketing to drug R&amp;D and device development. Available every Friday morning.&nbsp;

The Top Line

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech and Fierce Pharma recount the latest industry trends and why they matter. We’ll analyze the week’s biggest business news—from mergers and marketing to drug R&D and device development. Available every Friday morning.

 

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech and Fierce Pharma recount the latest industry trends and why they matter. We&rsquo;ll analyze the week&rsquo;s biggest business news&mdash;from mergers and marketing to drug R&amp;D and device development. Available every Friday morning.
&nbsp;

The best biopharma M&A deals

In this episode of “The Top Line,” recorded on site at Fierce Biotech Week in Boston, Fierce’s Ayla Ellison sits down with Christelle Huguet, Ph.D., executive vice president and head of R&D at Ipsen, to discuss how the company is building its pipeline through external innovation while maintaining internal scientific accountability.

Huguet explains Ipsen’s approach to partnering, describing the company as an “accelerator” that helps move promising science from academic labs and biotech partners toward patients. She also discusses how Ipsen evaluates which programs move forward, why transparency with partners is essential from the start and what the company is watching as it heads into a year with several key clinical and regulatory milestones.

To learn more about the topics in this episode: 
Ipsen unveils data for Botox rival that drove long-acting anti-wrinkle jab into phase 3
Ipsen scuttles liver disease candidates from $952M Albireo acquisition

This week's episode is sponsored by IQVIA

In this episode of &ldquo;The Top Line,&rdquo; recorded on site at Fierce Biotech Week in Boston, Fierce&rsquo;s Ayla Ellison sits down with Christelle Huguet, Ph.D., executive vice president and head of R&amp;D at Ipsen, to discuss how the company is building its pipeline through external innovation while maintaining internal scientific accountability.
Huguet explains Ipsen&rsquo;s approach to partnering, describing the company as an &ldquo;accelerator&rdquo; that helps move promising science from academic labs and biotech partners toward patients. She also discusses how Ipsen evaluates which programs move forward, why transparency with partners is essential from the start and what the company is watching as it heads into a year with several key clinical and regulatory milestones.
To learn more about the topics in this episode:&nbsp;
<ul>
<li><a href="https://www.fiercebiotech.com/biotech/ipsen-posts-data-drove-long-acting-anti-wrinkle-jab-phase-3">Ipsen unveils data for Botox rival that drove long-acting anti-wrinkle jab into phase 3</a></li>
<li><a href="https://www.fiercebiotech.com/biotech/ipsen-scuttles-liver-disease-candidates-952m-albireo-acquisition">Ipsen scuttles liver disease candidates from $952M Albireo acquisition</a></li>
</ul>
This week's episode is sponsored by <a href="https://www.iqviabiotech.com/">IQVIA</a>

Ipsen R&D chief on pipeline discipline, partnerships and 2026 milestones

Marker 01

In this sponsored episode of The Top Line, experts from Myriad Genetics join host Stephanie Butler to examine how tumor-informed molecular residual disease, or MRD, testing is beginning to redefine what early insight can mean in oncology drug development. As biomarker-driven therapies become more precise, the ability to understand response earlier and more clearly is increasingly being viewed as foundational to smarter development strategy.

The discussion looks at how ultrasensitive, tumor-informed MRD assays can help track response over time, potentially surface deeper signals earlier and inform decisions that shape trial design, patient selection and regulatory direction. It also considers why these capabilities may become more important as oncology programs face growing pressure to balance speed, flexibility and evidence generation.

Listeners will hear why early diagnostic strategy is increasingly seen as a competitive differentiator, how MRD can help teams make better decisions sooner and why its role in oncology development is expected to continue to evolve and expand.

In this sponsored episode of The Top Line, experts from Myriad Genetics join host Stephanie Butler to examine how tumor-informed molecular residual disease, or MRD, testing is beginning to redefine what early insight can mean in oncology drug development. As biomarker-driven therapies become more precise, the ability to understand response earlier and more clearly is increasingly being viewed as foundational to smarter development strategy.
The discussion looks at how ultrasensitive, tumor-informed MRD assays can help track response over time, potentially surface deeper signals earlier and inform decisions that shape trial design, patient selection and regulatory direction. It also considers why these capabilities may become more important as oncology programs face growing pressure to balance speed, flexibility and evidence generation.
Listeners will hear why early diagnostic strategy is increasingly seen as a competitive differentiator, how MRD can help teams make better decisions sooner and why its role in oncology development is expected to continue to evolve and expand.

Why MRD is becoming central to oncology drug development (Sponsored)

Each year, the global oncology community flocks to Chicago to convene at the American Society of Clinical Oncology’s annual meeting for a weekend of buzzy data drops, practice-changing posters and insightful sessions.  

In this week’s episode of "The Top Line," Fierce Biotech and Fierce Pharma’s Darren Incorvaia, Zoey Becker and Angus Liu break down the biggest takeaways from their weekend of reporting live from the Windy City. From “nutty” in vivo CAR-T data to a historic first for a Chinese biotech asset, ASCO 2026 reflected new and continuing trends within the evolving state of cancer care today.  

To learn more about the topics in this episode:  


ASCO: Revolution Medicines confident in RAS leadership as rivals square up 


ASCO: Lilly exec points to ‘nutty’ 100% response rate for in vivo CAR-T as justifying Kelonia buyout 


ASCO preview: With expectations jacked up, Akeso's ivonescimab to face scrutiny in high-stakes plenary 

This week's episode is sponsored by IQVIA

Each year, the global oncology community flocks to Chicago to convene at the American Society of Clinical Oncology&rsquo;s annual meeting for a weekend of buzzy data drops, practice-changing posters and insightful sessions.&nbsp;&nbsp;
In this week&rsquo;s episode of "The Top Line," Fierce Biotech and Fierce Pharma&rsquo;s Darren Incorvaia, Zoey Becker and Angus Liu break down the biggest takeaways from their weekend of reporting live from the Windy City. From &ldquo;nutty&rdquo; in vivo CAR-T data to a historic first for a Chinese biotech asset, ASCO 2026 reflected new and continuing trends within the evolving state of cancer care today.&nbsp;&nbsp;
To learn more about the topics in this episode:&nbsp;&nbsp;
<ul>
<li>
<a href="https://www.fiercebiotech.com/biotech/asco-revolution-medicines-confident-ras-leadership-rivals-square">ASCO: Revolution Medicines confident in RAS leadership as rivals square up</a>&nbsp;
</li>
</ul>
<ul>
<li>
<a href="https://www.fiercebiotech.com/biotech/asco-kelonia-keeps-vivo-car-t-momentum-rolling-nutty-100-response-rate">ASCO: Lilly exec points to &lsquo;nutty&rsquo; 100% response rate for in vivo CAR-T as justifying Kelonia buyout</a>&nbsp;
</li>
<li>
<a href="https://www.fiercepharma.com/pharma/asco-preview-expectations-jacked-akeso-ivonescimab-face-scrutiny-high-stakes-plenary">ASCO preview: With expectations jacked up, Akeso's ivonescimab to face scrutiny in high-stakes plenary</a>&nbsp;
</li>
</ul>
This week's episode is sponsored by <a href="https://www.iqviabiotech.com/">IQVIA</a>

The best biopharma M&A deals

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