After a turbulent 2025, the biopharma industry is heading into the new year with major questions still unresolved.

A tough biotech investing environment, aggressive direct-to-consumer drug marketing and sweeping U.S. policy changes reshaped the landscape last year. Many of those pressures are expected to persist into 2026, even as early signs point to a thaw in venture capital. At the same time, the industry is testing whether DTC drug sales can meaningfully affect pricing for patients and whether broad manufacturing onshoring goals can realistically apply to advanced therapies like cell and gene treatments and radiopharmaceuticals.

In this week’s episode of "The Top Line," Fierce Pharma’s Fraiser Kansteiner sits down with three biopharma CEOs to unpack what defined 2025 and what comes next. He’s joined by Thijs Spoor, CEO of Perspective Therapeutics; Brian Culley, CEO of Lineage Cell Therapeutics; and Rich Daly, CEO of Catalyst Pharmaceuticals.

Together, they tackle issues from DTC sales and onshore manufacturing to drug pricing, regulatory uncertainty at the FDA and the broader innovations the leaders are most excited about this year.

To learn more about the topics in this episode: 
2026 forecast: After a surge of M&A in Q4, will the trend continue?
Editor's Corner: Fierce Biotech's 10 most-read stories of 2025
What a year: Here are the stories that captivated our audience in 2025
Editor's Corner: The top 10 Fierce Pharma Marketing stories of 2025
2026 forecast: Pharma clicks with patients as direct sales model shifts marketing strategies

After a turbulent 2025, the biopharma industry is heading into the new year with major questions still unresolved.
A tough biotech investing environment, aggressive direct-to-consumer drug marketing and sweeping U.S. policy changes reshaped the landscape last year. Many of those pressures are expected to persist into 2026, even as early signs point to a thaw in venture capital. At the same time, the industry is testing whether DTC drug sales can meaningfully affect pricing for patients and whether broad manufacturing onshoring goals can realistically apply to advanced therapies like cell and gene treatments and radiopharmaceuticals.
In this week&rsquo;s episode of "The Top Line," Fierce Pharma&rsquo;s Fraiser Kansteiner sits down with three biopharma CEOs to unpack what defined 2025 and what comes next. He&rsquo;s joined by Thijs Spoor, CEO of Perspective Therapeutics; Brian Culley, CEO of Lineage Cell Therapeutics; and Rich Daly, CEO of Catalyst Pharmaceuticals.
Together, they tackle issues from DTC sales and onshore manufacturing to drug pricing, regulatory uncertainty at the FDA and the broader innovations the leaders are most excited about this year.
To learn more about the topics in this episode:&nbsp;
<ul>
<li><a href="https://www.fiercepharma.com/pharma/2026-forecast-after-surge-ma-q4-will-trend-continue-next-year">2026 forecast: After a surge of M&amp;A in Q4, will the trend continue?</a></li>
<li><a href="https://www.fiercebiotech.com/biotech/editors-corner-fierce-biotechs-10-most-read-stories-2025">Editor's Corner: Fierce Biotech's 10 most-read stories of 2025</a></li>
<li><a href="https://www.fiercepharma.com/pharma/what-year-here-are-stories-captivated-our-audience-2025">What a year: Here are the stories that captivated our audience in 2025</a></li>
<li><a href="https://www.fiercepharma.com/marketing/editors-corner-top-10-fierce-pharma-marketing-stories-2025">Editor's Corner: The top 10 Fierce Pharma Marketing stories of 2025</a></li>
<li><a href="https://www.fiercepharma.com/marketing/pharma-clicks-patients-direct-sales-model-shifts-marketing-strategies">2026 forecast: Pharma clicks with patients as direct sales model shifts marketing strategies</a></li>
</ul>

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech, and Fierce Pharma recount the latest industry trends and why they matter. We'll analyze the week's biggest business news, from mergers and marketing to drug R&D and device development. Available every Friday morning. 

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech, and Fierce Pharma recount the latest industry trends and why they matter. We'll analyze the week's biggest business news, from mergers and marketing to drug R&amp;D and device development. Available every Friday morning.&nbsp;

The Top Line

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech and Fierce Pharma recount the latest industry trends and why they matter. We’ll analyze the week’s biggest business news—from mergers and marketing to drug R&D and device development. Available every Friday morning.

 

Biopharma and medtech explained. Every week, journalists from Fierce Biotech, Fierce Medtech and Fierce Pharma recount the latest industry trends and why they matter. We&rsquo;ll analyze the week&rsquo;s biggest business news&mdash;from mergers and marketing to drug R&amp;D and device development. Available every Friday morning.
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