This is the last episode in the series on Kala Azar reported by Suno India’s Menaka Rao. 

The Indian government has said that it has hit the elimination target for Kala-azar, a parasitic disease that is life-threatening. But miltefosine, the drug used to treat the skin manifestation of Kala-azar, called Post-Kala-azar Dermal Leishmaniasis (PKDL), is being linked to eye problems, including blindness. 

The government has taken steps to try to reduce the side effects in 2021, but not much has been done for those who have lost their eyesight either in one eye or both, possibly as a result of miltefosine. The World Health Organization has found 83 cases of people in India who have suffered a problem in the eye after intake of miltefosine. 

In this episode, Menaka spoke to Iliyas Marandi, one of the patients who lost his eyesight completely after taking miltefosine treatment. She also spoke to ophthalmologists Dr Rakhi Kushumesh and Dr Asim Sil who treated such patients, and helped develop the guidelines to prevent such ocular side effects. 



References 

https://www.indiaspend.com/health/how-a-drug-to-treat-dermal-kala-azar-is-affecting-patients-eyesight-901497

Keratitis occurring in patients treated with miltefosine for post-kala-azar dermal leishmaniasis | British Journal of Ophthalmology

https://ncvbdc.mohfw.gov.in/WriteReadData/l892s/PKDL-Guidelines-220512.pdf

Using focused pharmacovigilance for ensuring patient safety against antileishmanial drugs in Bangladesh's National Kala-azar Elimination Programme

Keratitis After Post-Kala-Azar Dermal Leishmaniasis

Corneal complications following Post Kala-azar Dermal Leishmaniasis treatment | PLOS Neglected Tropical Diseases

Adverse ocular events on miltefosine treatment for post-kala-azar dermal leishmaniasis in India - Suman Saurabh, Manish Mahabir, 2020

Advisory Committee on Safety of Medicinal Products (ACSoMP): Measures to minimize the risk of ocular adverse events with miltefosine

Statement on miltefosine - Potential ocular disorders in patients treated with miltefosine for post-kala-azar dermal leishmaniasis (PKDL).

This is the last episode in the series on Kala Azar reported by Suno India’s Menaka Rao. 
The Indian government has said that it has hit the elimination target for Kala-azar, a parasitic disease that is life-threatening. But miltefosine, the drug used to treat the skin manifestation of Kala-azar, called Post-Kala-azar Dermal Leishmaniasis (PKDL), is being linked to eye problems, including blindness. 
The government has taken steps to try to reduce the side effects in 2021, but not much has been done for those who have lost their eyesight either in one eye or both, possibly as a result of miltefosine. The World Health Organization has found 83 cases of people in India who have suffered a problem in the eye after intake of miltefosine. 
In this episode, Menaka spoke to Iliyas Marandi, one of the patients who lost his eyesight completely after taking miltefosine treatment. She also spoke to ophthalmologists Dr Rakhi Kushumesh and Dr Asim Sil who treated such patients, and helped develop the guidelines to prevent such ocular side effects. 
 
References 
<a href="https://www.indiaspend.com/health/how-a-drug-to-treat-dermal-kala-azar-is-affecting-patients-eyesight-901497">https://www.indiaspend.com/health/how-a-drug-to-treat-dermal-kala-azar-is-affecting-patients-eyesight-901497</a>
<a href="https://bjo.bmj.com/content/105/11/1497">Keratitis occurring in patients treated with miltefosine for post-kala-azar dermal leishmaniasis | British Journal of Ophthalmology</a>
<a href="https://ncvbdc.mohfw.gov.in/WriteReadData/l892s/PKDL-Guidelines-220512.pdf">https://ncvbdc.mohfw.gov.in/WriteReadData/l892s/PKDL-Guidelines-220512.pdf</a>
<a href="https://pubmed.ncbi.nlm.nih.gov/30099967/">Using focused pharmacovigilance for ensuring patient safety against antileishmanial drugs in Bangladesh's National Kala-azar Elimination Programme</a>
<a href="https://pubmed.ncbi.nlm.nih.gov/29040115/">Keratitis After Post-Kala-Azar Dermal Leishmaniasis</a>
<a href="https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006781">Corneal complications following Post Kala-azar Dermal Leishmaniasis treatment | PLOS Neglected Tropical Diseases</a>
<a href="https://journals.sagepub.com/doi/10.1177/0049475519877317">Adverse ocular events on miltefosine treatment for post-kala-azar dermal leishmaniasis in India - Suman Saurabh, Manish Mahabir, 2020</a>
<a href="https://cdn.who.int/media/docs/default-source/medicines/pharmacovigilance/miltefosine-2023.pdf?sfvrsn=13e0c48c_3">Advisory Committee on Safety of Medicinal Products (ACSoMP): Measures to minimize the risk of ocular adverse events with miltefosine</a>
<a href="https://www.who.int/news/item/10-02-2022-statement-on-miltefosine---potential-ocular-disorders-in-patients-treated-with-miltefosine-for-post-kala-azar-dermal-leishmaniasis-(pkdl)#:~:text=dermal%20leishmaniasis%20(PKDL)-,Statement%20on%20miltefosine%20%2D%20Potential%20ocular%20disorders%20in%20patients%20treated%20with,%2Dazar%20dermal%20leishmaniasis%20(PKDL)&amp;text=Miltefosine%20is%20an%20oral%20anti,parasitic%20infection%20spread%20by%20sandflies">Statement on miltefosine - Potential ocular disorders in patients treated with miltefosine for post-kala-azar dermal leishmaniasis (PKDL)</a>.

The Suno India Show’ is a news show by Suno India combining slow journalism with under-represented and under-reported stories. Covering the diverse range of topics like politics, technology, education and society, the host brings in informative interviews and engaging discussions with experts. The show not only shines a spotlight on stories that matter but keeps the listeners up to date with the latest national news.

The Suno India Show&rsquo; is a news show by Suno India combining slow journalism with under-represented and under-reported stories. Covering the diverse range of topics like politics, technology, education and society, the host brings in informative interviews and engaging discussions with experts. The show not only shines a spotlight on stories that matter but keeps the listeners up to date with the latest national news.

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