In Part 1 of a two-part interview, University of Toronto's Roger McIntyre discusses treatment-resistant depression, why many antidepressants fall short, and the growing promise of ketamine. Then, Ozempic for depression? The latest on GLP-1s and mental health.

Hosted by Jeyan Jeganathan, The Rundown delivers original journalism and in-depth analysis of the social, political, cultural, and economic issues that shape life in Ontario. Each episode focuses on one topic that’s making headlines, examining it from different angles and through diverse points of view — providing the context you need to understand what’s happening in the province and around the world.

<p data-renderer-start-pos="1">Hosted by Jeyan Jeganathan, The Rundown delivers original journalism and in-depth analysis of the social, political, cultural, and economic issues that shape life in Ontario. Each episode focuses on one topic that&rsquo;s making headlines, examining it from different angles and through diverse points of view &mdash; providing the context you need to understand what&rsquo;s happening in the province and around the world.</p>

Hosted by Jeyan Jeganathan, The Rundown delivers original journalism and in-depth analysis of the social, political, cultural, and economic issues that shape life in Ontario. 