In Part 1 of a two-part interview, University of Toronto's Roger McIntyre discusses treatment-resistant depression, why many antidepressants fall short, and the growing promise of ketamine. Then, Ozempic for depression? The latest on GLP-1s and mental health.

Hosted by Jeyan Jeganathan, The Rundown delivers original journalism and in-depth analysis of the social, political, cultural, and economic issues that shape life in Ontario. Each episode focuses on one topic that’s making headlines, examining it from different angles and through diverse points of view — providing the context you need to understand what’s happening in the province and around the world.

<p data-renderer-start-pos="1">Hosted by Jeyan Jeganathan, The Rundown delivers original journalism and in-depth analysis of the social, political, cultural, and economic issues that shape life in Ontario. Each episode focuses on one topic that&rsquo;s making headlines, examining it from different angles and through diverse points of view &mdash; providing the context you need to understand what&rsquo;s happening in the province and around the world.</p>

Hosted by Jeyan Jeganathan, The Rundown delivers original journalism and in-depth analysis of the social, political, cultural, and economic issues that shape life in Ontario. 

The Rundown

Is Ketamine Revolutionizing the Treatment of Depression?

Young men are often told to tough it out, but a new report from GreenShield and Mental Health Research Canada suggests many may be struggling in silence, raising questions about why so many are reluctant to seek help when they need it most. Khush Amaria, director of clinical services at GreenShield, joins Jeyan to unpack the findings. Then, as loneliness becomes a growing concern, some people are turning to AI chatbots for companionship. Can a machine provide meaningful connection, or does it risk deepening the problem? University of Toronto psychology professor Paul Bloom weighs in.

Why Are So Many Young Men Suffering in Silence?

Canada is preparing for major nation-building projects while entering trade talks with the United States and Mexico, promising partnership with Indigenous peoples but leaving questions about what that means in practice. How will those commitments be carried out, and whose voices will shape the outcome? At the same time, Indigenous humour offers insight into culture, identity, and connection, reflecting shared experience while challenging assumptions. What makes it distinct, and can it help build understanding across communities? Anishinaabe journalist Tanya Talaga and playwright and author Drew Hayden Taylor join the conversation.

Can Indigenous Voices Reshape Canada's Next Big Projects?

Prime Minister Mark Carney met with world leaders at the G7 in France, trying to position Canada in an increasingly uncertain global order, new questions are emerging about the country's economic stability and its most critical trade relationship. U.S. President Donald Trump has cast doubt on the future of the Canada-U.S.-Mexico Agreement, saying "I'm not looking to renew it" and "we don't need anything that Canada has," with a key deadline approaching. How exposed is Canada if that deal unravels, and how should its foreign and economic strategy adapt? Arif Lalani, Shannon Gormley, Adam Chapnick, and Drew Fagan join Jeyan to discuss.

Is Ketamine Revolutionizing the Treatment of Depression?

The Rundown

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