Here is the second part of my conversation with biochemist Jon Brudvig to delve into the fascinating world of longevity and contemporary health interventions. We tackle topics ranging from SGLT2 inhibitors and their unexpected benefits to the controversial nature of microplastics in our environment. This dialogue is a treasure trove for anyone interested in the intersections of health, science, and longevity.

What You'll Learn:

Exploring SGLT2 Inhibitors: Discover the multifaceted benefits of SGLT2 inhibitors, originally diabetes drugs, for heart, kidney, and possibly cognitive health.

Metformin: A Mixed Bag: Get an overview of the metformin debate, examining its potential benefits and the contentious nature of the research.

Fasting Fundamentals: Gain insights into intermittent fasting, its impact on metabolism, potential benefits, and the critical role of resistance training to mitigate muscle loss.

Microplastics: An Underestimated Threat: Learn about the insidious presence of microplastics in human tissues and their potential health repercussions.

Potential Interventions: Hear about experimental approaches to reducing microplastics in the body, including the potential role of sulforaphane.

Key Takeaways:
SGLT2 inhibitors: These drugs have shown promising longevity benefits beyond their initial purpose for diabetes management.
Metformin's Controversy: While some data suggests potential longevity benefits, criticism exists regarding its exercise interference and study methodologies.
The Role of Fasting: Intermittent fasting can be beneficial, particularly for metabolic health, but must be carefully balanced with nutritional needs and physical activity.
Microplastics Concern: Ubiquitous in the environment, microplastics are potentially linked to inflammation and adverse health outcomes, necessitating further research and interventions.
Self-Experimentation: Personal health experiments, like those done by Jon Brudvig, highlight the importance of understanding one’s own biology in response to health interventions.

Resources:

Connect with Dr. Jon Brudvig for more insights into longevity and health:

LinkedIn:Jon Brudvig 

Substack: https://jonbrudvig.substack.com/

 

Support the Podcast:

If you found this episode valuable, please consider subscribing to our podcast and leaving a review. Your feedback helps us continue bringing important conversations like these to a wider audience.

Whether you're driven by personal health challenges or broader scientific curiosity, this conversation provides a unique peek into the current and future possibilities of living healthier, longer lives. Share this with individuals passionate about health and longevity, and join the ongoing dialogue to advance our understanding and well-being.

00:12 Understanding SGLT2 Inhibitors

02:51 Mendelian Randomization and SGLT2 Inhibitors

06:24 Benefits and Mechanisms of SGLT2 Inhibitors

09:47 Discussion on Metformin

14:36 Intermittent Fasting and Ketone Supplements

17:46 Fasting, Autophagy, and Muscle Health

22:38 Exploring Glycine and N-Acetyl Cysteine

24:48 Microplastics: A Growing Concern

26:25 The Impact of Microplastics on Health

31:54 Self-Experimentation with Sulforaphane

38:33 Final Thoughts and Future Work

 

 

 

 

 

Here is the second part of my conversation with biochemist Jon Brudvig to delve into the fascinating world of longevity and contemporary health interventions. We tackle topics ranging from SGLT2 inhibitors and their unexpected benefits to the controversial nature of microplastics in our environment. This dialogue is a treasure trove for anyone interested in the intersections of health, science, and longevity.
What You'll Learn:
Exploring SGLT2 Inhibitors: Discover the multifaceted benefits of SGLT2 inhibitors, originally diabetes drugs, for heart, kidney, and possibly cognitive health.
Metformin: A Mixed Bag: Get an overview of the metformin debate, examining its potential benefits and the contentious nature of the research.
Fasting Fundamentals: Gain insights into intermittent fasting, its impact on metabolism, potential benefits, and the critical role of resistance training to mitigate muscle loss.
Microplastics: An Underestimated Threat: Learn about the insidious presence of microplastics in human tissues and their potential health repercussions.
Potential Interventions: Hear about experimental approaches to reducing microplastics in the body, including the potential role of sulforaphane.
Key Takeaways:
<ul>
<li>SGLT2 inhibitors: These drugs have shown promising longevity benefits beyond their initial purpose for diabetes management.</li>
<li>Metformin's Controversy: While some data suggests potential longevity benefits, criticism exists regarding its exercise interference and study methodologies.</li>
<li>The Role of Fasting: Intermittent fasting can be beneficial, particularly for metabolic health, but must be carefully balanced with nutritional needs and physical activity.</li>
<li>Microplastics Concern: Ubiquitous in the environment, microplastics are potentially linked to inflammation and adverse health outcomes, necessitating further research and interventions.</li>
<li>Self-Experimentation: Personal health experiments, like those done by Jon Brudvig, highlight the importance of understanding one&rsquo;s own biology in response to health interventions.</li>
</ul>
Resources:
Connect with Dr. Jon Brudvig for more insights into longevity and health:
LinkedIn: <a href="https://www.linkedin.com/in/jon-brudvig-phd-9b1830134/">Jon Brudvig</a>&nbsp;
Substack: https://jonbrudvig.substack.com/
&nbsp;
Support the Podcast:
If you found this episode valuable, please consider subscribing to our podcast and leaving a review. Your feedback helps us continue bringing important conversations like these to a wider audience.
Whether you're driven by personal health challenges or broader scientific curiosity, this conversation provides a unique peek into the current and future possibilities of living healthier, longer lives. Share this with individuals passionate about health and longevity, and join the ongoing dialogue to advance our understanding and well-being.
00:12&nbsp;Understanding SGLT2 Inhibitors
02:51&nbsp;Mendelian Randomization and SGLT2 Inhibitors
06:24&nbsp;Benefits and Mechanisms of SGLT2 Inhibitors
09:47&nbsp;Discussion on Metformin
14:36&nbsp;Intermittent Fasting and Ketone Supplements
17:46&nbsp;Fasting, Autophagy, and Muscle Health
22:38&nbsp;Exploring Glycine and N-Acetyl Cysteine
24:48&nbsp;Microplastics: A Growing Concern
26:25&nbsp;The Impact of Microplastics on Health
31:54&nbsp;Self-Experimentation with Sulforaphane
38:33&nbsp;Final Thoughts and Future Work
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&nbsp;
&nbsp;
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Host Dr Paul Taylor, a Psychophysiologist, Neuroscientist, Exercise Scientist, and Nutritionist interviews experts from around the world on cutting edge research and practices related to improving hardiness in your mind, body and brain to become your best self.

Host Dr Paul Taylor, a Psychophysiologist, Neuroscientist, Exercise Scientist, and Nutritionist interviews experts from around the world on cutting edge research and practices related to improving hardiness in your mind, body and brain to become your best self.

Hardiness with Dr Paul Taylor

Host Dr Paul Taylor, a Psychophysiologist, Neuroscientist, Exercise Scientist, and Nutritionist interviews experts from around the world on cutting edge research and practices related to improving hardiness in your mind, body and brain to become your best self. 

Host Dr Paul Taylor, a Psychophysiologist, Neuroscientist, Exercise Scientist, and Nutritionist interviews experts from around the world on cutting edge research and practices related to improving hardiness in your mind, body and brain to become your best self.&nbsp;

Unpacking Longevity and Cellular Health: A Conversation with Dr. Jon Brudvig - Part Two

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