Multi-omics is the layering of genetic information (genomics) with laboratory biomarker results (metabolomics) to understand the root cause of disease and risk. This educational series focuses on genetic variants in specific enzymes and explains how to evaluate the systemic effects.

Today’s episode revolves around the enzyme cystathionine-beta-synthase (CBS). This enzyme is important for homocysteine metabolism, sitting at a branch point between two important cycles: methylation and transsulfuration. The action of this enzyme is important for balancing the critical functions of methylation with the creation of glutathione and energy. Listen to understand why this enzyme is important and what a genetic variant in CBS might mean for you and your patients.

Today on The Lab Report: 
2:20 Reminder of what we mean by multi-omics
4:50 Introducing the CBS enzyme and the sink drain metaphor
7:40 The genetics of CBS – the silent mutation – and its potential effects
12:40 Better Know A Biomarker:  Cystathionine!
16:20 Activators and inhibitors of CBS and its effects on other biomarkers
18:55 Question of the Day: 

Does a CBS SNP cause elevated ammonia levels?
21:40 Evaluating surrounding biomarkers and how do you treat this SNP?

Additional Resources:

Methylation Panel 

Genova Connect **PROMO CODE TheLabReport20 for 20% off your purchase**



Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net.

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit Genova Connect.

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and show not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

Multi-omics is the layering of genetic information (genomics) with laboratory biomarker results (metabolomics) to understand the root cause of disease and risk. This educational series focuses on genetic variants in specific enzymes and explains how to evaluate the systemic effects.
Today’s episode revolves around the enzyme cystathionine-beta-synthase (CBS). This enzyme is important for homocysteine metabolism, sitting at a branch point between two important cycles: methylation and transsulfuration. The action of this enzyme is important for balancing the critical functions of methylation with the creation of glutathione and energy. Listen to understand why this enzyme is important and what a genetic variant in CBS might mean for you and your patients.
Today on The Lab Report: 
<ul>
<li>2:20 Reminder of what we mean by multi-omics</li>
<li>4:50 Introducing the CBS enzyme and the sink drain metaphor</li>
<li>7:40 The genetics of CBS – the silent mutation – and its potential effects</li>
<li>12:40 Better Know A Biomarker:  Cystathionine!</li>
<li>16:20 Activators and inhibitors of CBS and its effects on other biomarkers</li>
<li>18:55 Question of the Day: 
<ul>
<li>Does a CBS SNP cause elevated ammonia levels?</li>
</ul>
</li>
<li>21:40 Evaluating surrounding biomarkers and how do you treat this SNP?</li>
</ul>
Additional Resources:
<a href="https://www.gdx.net/products/methylation-panel">Methylation Panel </a>
<a href="https://connect.gdx.net/">Genova Connect </a>**PROMO CODE TheLabReport20 for 20% off your purchase**
 
Subscribe, Rate, &amp; Review The Lab Report
Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.
Don’t forget to <a href="https://www.gdx.net/">visit our website</a>, like us on <a href="https://www.facebook.com/genova.diagnostics/">Facebook</a>, follow us on <a href="https://twitter.com/genova_gdx">Twitter</a>, <a href="https://www.instagram.com/genovadiagnostics/">Instagram</a>, and <a href="https://www.linkedin.com/company/genova-diagnostics">LinkedIn</a>. Email Patti and Michael with your most interesting and pressing questions on functional medicine: <a href="mailto:podcast@gdx.net">podcast@gdx.net</a>.
And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.
To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly yourself, visit <a href="https://connect.gdx.net/">Genova Connect</a>.
Disclaimer: The content and information shared in The Lab Report is for educational purposes only and show not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

The world of medicine can be challenging. Clinicians and patients are always looking for more options, more effective treatments… and in the end, more answers. What if there was a way to practice medicine that digs deeper and offers a new perspective? Functional medicine focuses on addressing root causes of disease. At Genova Diagnostics we’ve watched this field evolve and grow for over 35 years….

We’ve not only adapted, we’ve led. Join us as we talk about functional medicine, laboratory testing, and optimizing health. Welcome to the Lab Report.

Functional Medicine, Specialty Lab Testing, and Integrative Therapeutics

Advertisement