Mast Cell Activation Syndrome (MCAS) has become a hot topic in functional medicine. Mast cells are an integral part of the body’s immune system. They can be found in areas of exposure such as mucosal membranes, the lining of the GI tract, skin, and airways. Mast cells are responsible for storing important chemical mediators like histamine and others which help to instigate allergic responses. Mast cell disorders arise when there are too many mast cells, or they become hyper-reactive. That being said, these conditions are often misunderstood, and diagnoses are sometimes misused. 

In today’s episode, we focus on the role of mast cells and histamine in the immune response. We discuss the different mast cell activation disorders, how to diagnose them, and what you can do about it.  

Today on The Lab Report: 
3:05      Mast Cell Activation Diseases 
5:15      What is a mast cell? Why do we care?  
7:05      Symptoms of histamine release  
8:40      Histamine intolerance vs. MCAS  
11:11     Foods: High Histamine or Low Histamine?  
14:25    Non-food related histamine associations 
15:30    Diagnosing and treating MCAS  
18:00    Question of the Day


What Genova profiles can help parse out histamine intolerance v. MCAS?  

Additional Resources: 

IgE Food Antibodies Profile 

IgE Inhalants - Allergy Profile

IgE Mold - Allergy Profile

Methylation Panel

Subscribe, Rate, & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. 

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net.  

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.  

To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit Genova Connect.  

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.  

Mast Cell Activation Syndrome (MCAS) has become a hot topic in functional medicine. Mast cells are an integral part of the body’s immune system. They can be found in areas of exposure such as mucosal membranes, the lining of the GI tract, skin, and airways. Mast cells are responsible for storing important chemical mediators like histamine and others which help to instigate allergic responses. Mast cell disorders arise when there are too many mast cells, or they become hyper-reactive. That being said, these conditions are often misunderstood, and diagnoses are sometimes misused. 
In today’s episode, we focus on the role of mast cells and histamine in the immune response. We discuss the different mast cell activation disorders, how to diagnose them, and what you can do about it.  
Today on The Lab Report:  
<ul>
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<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}" aria-setsize="-1" data-aria-posinset="2" data-aria-level="1">5:15      What is a mast cell? Why do we care?  </li>
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}" aria-setsize="-1" data-aria-posinset="3" data-aria-level="1">7:05      Symptoms of histamine release  </li>
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}" aria-setsize="-1" data-aria-posinset="4" data-aria-level="1">8:40      Histamine intolerance vs. MCAS  </li>
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}" aria-setsize="-1" data-aria-posinset="5" data-aria-level="1">11:11     Foods: High Histamine or Low Histamine?  </li>
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}" aria-setsize="-1" data-aria-posinset="6" data-aria-level="1">14:25    Non-food related histamine associations </li>
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}" aria-setsize="-1" data-aria-posinset="7" data-aria-level="1">15:30    Diagnosing and treating MCAS  </li>
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}" aria-setsize="-1" data-aria-posinset="8" data-aria-level="1">18:00    Question of the Day
<ul>
<li>
<ul>
<li data-leveltext="" data-font="Symbol" data-listid="1" data-list-defn-props="{&quot;335552541&quot;:1,&quot;335559683&quot;:0,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}" aria-setsize="-1" data-aria-posinset="8" data-aria-level="1">What Genova profiles can help parse out histamine intolerance v. MCAS?  </li>
</ul>
</li>
</ul>
</li>
</ul>
Additional Resources:  
<a href="https://www.gdx.net/product/ige-food-allergy-test-blood">IgE Food Antibodies Profile </a> 
<a href="https://www.gdx.net/product/ige-inhalants-allergy-test-blood">IgE Inhalants - Allergy Profile</a> 
<a href="https://www.gdx.net/product/ige-mold-allergy-test-blood">IgE Mold - Allergy Profile</a> 
<a href="https://www.gdx.net/product/methylation">Methylation Panel</a> 
Subscribe, Rate, &amp; Review The Lab Report 
Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review. 
Don’t forget to <a href="https://www.gdx.net/">visit our website</a>, like us on <a href="https://www.facebook.com/genova.diagnostics/">Facebook</a>, follow us on <a href="https://twitter.com/genova_gdx">Twitter</a>, <a href="https://www.instagram.com/genovadiagnostics/">Instagram</a>, and <a href="https://www.linkedin.com/company/genova-diagnostics">LinkedIn</a>. Email Patti and Michael with your most interesting and pressing questions on functional medicine: <a href="mailto:podcast@gdx.net">podcast@gdx.net</a>.  
And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.  
To find a qualified healthcare provider to connect you with Genova testing, or to access select products directly, visit <a href="https://connect.gdx.net/">Genova Connect</a>.  
Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions and views of Michael Chapman and Patti Devers and their guests.

The world of medicine can be challenging. Clinicians and patients are always looking for more options, more effective treatments… and in the end, more answers. What if there was a way to practice medicine that digs deeper and offers a new perspective? Functional medicine focuses on addressing root causes of disease. At Genova Diagnostics we’ve watched this field evolve and grow for over 35 years….

We’ve not only adapted, we’ve led. Join us as we talk about functional medicine, laboratory testing, and optimizing health. Welcome to the Lab Report.

Functional Medicine, Specialty Lab Testing, and Integrative Therapeutics

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