A multi-omic assessment combines your genetic blueprint (genomics) with laboratory biomarker information (metabolomics) to provide a deeper understanding of the root cause of disease or disease risk. By starting with a specific enzyme and discussing what it does in the body, we can start to map its systemic effects and gather important data. When there are genetic variants in that enzyme many systems can be affected.

Today’s episode discusses the enzyme 5,10 methylenetetrahydrofolate reductase or “MTHFR”. In functional medicine, MTHFR is a common topic that is often debated and misunderstood. We explain what MTHFR does in the body and why it is important. Genetic variants in this enzyme can predispose a person to many clinical conditions but these are not always expressed. Hear why that is, and what you need to assess to get the full picture.

“Genes do not make your destiny, and SNPs do not always manifest themselves as a biological or functional problem.” – Michael Chapman

Today on The Lab Report Podcast:
2:30 What is a multi-omics assessment?
4:00 The basics of methylation and why it’s important
7:00 What is MTHFR and how does it relate to folate and methylation
8:55 Possible effects of genetic single nucleotide polymorphisms (SNPs) related to MTHFR
11:30 Which profiles and biomarkers can give multi-omic information about MTHFR SNPs?
16:45 How do we support patients with MTHFR SNPs, and should we give methylated vitamins
22:05 Question of the day: “How common is it to have an MTHFR SNP?”

Subscribe, Rate & Review The Lab Report

Thanks for tuning in to this week’s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.

Don’t forget to visit our website, like us on Facebook, follow us on Twitter, Instagram, and LinkedIn. Email Patti and Michael with your most interesting and pressing questions on functional medicine: podcast@gdx.net.

And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.

~~

Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions of Michael Chapman and Patti Devers and their guests.

For medical advice, diagnosis, and/or treatment, please consult a medical professional.

A multi-omic assessment combines your genetic blueprint (genomics) with laboratory biomarker information (metabolomics) to provide a deeper understanding of the root cause of disease or disease risk. By starting with a specific enzyme and discussing what it does in the body, we can start to map its systemic effects and gather important data. When there are genetic variants in that enzyme many systems can be affected.
Today&rsquo;s episode discusses the enzyme 5,10 methylenetetrahydrofolate reductase or &ldquo;MTHFR&rdquo;. In functional medicine, MTHFR is a common topic that is often debated and misunderstood. We explain what MTHFR does in the body and why it is important. Genetic variants in this enzyme can predispose a person to many clinical conditions but these are not always expressed. Hear why that is, and what you need to assess to get the full picture.
&ldquo;Genes do not make your destiny, and SNPs do not always manifest themselves as a biological or functional problem.&rdquo; &ndash; Michael Chapman
Today on The Lab Report Podcast:
<ul>
<li>2:30 What is a multi-omics assessment?</li>
<li>4:00 The basics of methylation and why it&rsquo;s important</li>
<li>7:00 What is MTHFR and how does it relate to folate and methylation</li>
<li>8:55 Possible effects of genetic single nucleotide polymorphisms (SNPs) related to MTHFR</li>
<li>11:30 Which profiles and biomarkers can give multi-omic information about MTHFR SNPs?</li>
<li>16:45 How do we support patients with MTHFR SNPs, and should we give methylated vitamins</li>
<li>22:05 Question of the day: &ldquo;How common is it to have an MTHFR SNP?&rdquo;</li>
</ul>
Subscribe, Rate &amp; Review The Lab Report
Thanks for tuning in to this week&rsquo;s episode of The Lab Report, presented by Genova Diagnostics, with your hosts Michael Chapman and Patti Devers. If you enjoyed this episode, please hit the subscribe button and give us a rating or leave a review.
Don&rsquo;t forget to <a href="https://www.gdx.net/">visit our website</a>, like us on <a href="https://www.facebook.com/genova.diagnostics/">Facebook</a>, follow us on <a href="https://twitter.com/genova_gdx">Twitter</a>, <a href="https://www.instagram.com/genovadiagnostics/">Instagram</a>, and <a href="https://www.linkedin.com/company/genova-diagnostics">LinkedIn</a>. Email Patti and Michael with your most interesting and pressing questions on functional medicine: <a href="mailto:podcast@gdx.net">podcast@gdx.net</a>.
And, be sure to share your favorite Lab Report episodes with your friends and colleagues on social media to help others learn more about Genova and all things related to functional medicine and specialty lab testing.
~~
Disclaimer: The content and information shared in The Lab Report is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in The Lab Report represent the opinions of Michael Chapman and Patti Devers and their guests.
For medical advice, diagnosis, and/or treatment, please consult a medical professional.

The world of medicine can be challenging. Clinicians and patients are always looking for more options, more effective treatments… and in the end, more answers. What if there was a way to practice medicine that digs deeper and offers a new perspective? Functional medicine focuses on addressing root causes of disease. At Genova Diagnostics we’ve watched this field evolve and grow for over 35 years….

We’ve not only adapted, we’ve led. Join us as we talk about functional medicine, laboratory testing, and optimizing health. Welcome to the Lab Report.

Functional Medicine, Specialty Lab Testing, and Integrative Therapeutics

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