This episode covers three examples of historically important roads. One is quite ancient, one is an important part of the development of the U.S., and the third is a more modern road that’s been lauded for its design.
Research:

Robert Moses and the Shaping of New York, Part 1
41:59

SYMHC Classics: Eradication of Smallpox
43:25

Behind the Scenes Minis: Progressive Medicine
22:11