Today's biggest winners and losers in the stock market.

On this episode of Stock Movers:

- Shares of Moderna (MRNA) surged by a record 101% - the stock’s biggest intraday gain on record - after the biotech said a personalized cancer vaccine combined with partner Merck & Co.’s Keytruda helped cut the recurrence of melanoma in a large, late-stage trial. The study also met a key secondary goal of showing the shot could help prevent tumors from spreading to new areas of the body, the companies said in a statement Wednesday.

- Shares of Estee Lauder (EL) rallied after the beauty company’s adjusted earnings per share and sales metrics topped consensus expectations for the fourth quarter. The midpoint of fiscal 2027 organic sales and adjusted EPS guidance ranges are above Street views.

- Shares of La-Z-Boy (LZB) tumbled at the open after the furniture maker’s forecast sales for the second quarter missed the average analyst estimate.

Today's biggest winners and losers in the stock market.
On this episode of Stock Movers:
- Shares of Moderna (MRNA) surged by a record 101% - the stock&rsquo;s biggest intraday gain on record - after the biotech said a personalized cancer vaccine combined with partner Merck &amp; Co.&rsquo;s Keytruda helped cut the recurrence of melanoma in a large, late-stage trial. The study also met a key secondary goal of showing the shot could help prevent tumors from spreading to new areas of the body, the companies said in a statement Wednesday.
- Shares of Estee Lauder (EL) rallied after the beauty company&rsquo;s adjusted earnings per share and sales metrics topped consensus expectations for the fourth quarter. The midpoint of fiscal 2027 organic sales and adjusted EPS guidance ranges are above Street views.
- Shares of La-Z-Boy (LZB) tumbled at the open after the furniture maker&rsquo;s forecast sales for the second quarter missed the average analyst estimate.

Listen for five-minute conversations on today's biggest winners and losers in the stock market. 

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Listen for five-minute conversations on today's biggest winners and losers in the stock market.&nbsp;
Subscribe for analysis on the companies making news in global equity markets. Episodes are published throughout the day to track stock moves from New York, London, Frankfurt and Paris. Join us for investment news covering technology, energy, finance, health care, communications, industrials, utilities, consumer staples, materials, real estate and more.

Listen for news on today's biggest winners and losers in the stock market.

Stock Movers

Moderna's Record Surge, Estee Lauder Rises on Q4 Beat, La-Z-Boy Sinks

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