Today's biggest winners and losers in the stock market.

On this episode of Stock Movers:

- Shares of Moderna (MRNA) surged by a record 101% - the stock’s biggest intraday gain on record - after the biotech said a personalized cancer vaccine combined with partner Merck & Co.’s Keytruda helped cut the recurrence of melanoma in a large, late-stage trial. The study also met a key secondary goal of showing the shot could help prevent tumors from spreading to new areas of the body, the companies said in a statement Wednesday.

- Shares of Estee Lauder (EL) rallied after the beauty company’s adjusted earnings per share and sales metrics topped consensus expectations for the fourth quarter. The midpoint of fiscal 2027 organic sales and adjusted EPS guidance ranges are above Street views.

- Shares of La-Z-Boy (LZB) tumbled at the open after the furniture maker’s forecast sales for the second quarter missed the average analyst estimate.