Today's biggest winners and losers in the stock market.
On this episode of Stock Movers:

Listen for comprehensive cross-platform coverage of the US market close as heard on Bloomberg Television, Bloomberg Radio, and YouTube with Romaine Bostick, Isabelle Lee, Carol Massar and Emily Graffeo

- Moderna (MRNA) shares surged, delivering a $5.5 billion blow to short sellers who had bet that the vaccine maker's slump would continue. The company's stock price soared 177% after it said its personalized cancer vaccine helped reduce the recurrence of melanoma in a late-stage trial. The jump generated paper losses of about $5.5 billion for short sellers, bringing mark-to-market losses to roughly $7.7 billion this year, according to data from S3 Partners LLC.

- Estée Lauder (EL) shares jumped after its results beat estimates and ended a run of three straight declines in annual revenue. The company reported revenue of $3.6 billion in its fiscal fourth quarter and adjusted earnings per share of $0.39, which topped expectations. The company reaffirmed guidance for organic net sales growth and raised guidance on its adjusted operating margin, with analysts saying a steady recovery is underway.

- TJ Maxx (TJX) shares fall 0.84% in Wednesday trading after the clothing retailer reported second-quarter comparable sales for its Marmaxx segment, which includes TJ Maxx and Marshalls, that missed the average analyst estimate.

Today's biggest winners and losers in the stock market. On this episode of Stock Movers: Listen for comprehensive cross-platform coverage of the US market close as heard on Bloomberg Television, Bloomberg Radio, and YouTube with Romaine Bostick, Isabelle Lee, Carol Massar and Emily Graffeo - Moderna (MRNA) shares surged, delivering a $5.5 billion blow to short sellers who had bet that the vaccine maker's slump would continue. The company's stock price soared 177% after it said its personalized cancer vaccine helped reduce the recurrence of melanoma in a late-stage trial. The jump generated paper losses of about $5.5 billion for short sellers, bringing mark-to-market losses to roughly $7.7 billion this year, according to data from S3 Partners LLC. - Est&eacute;e Lauder (EL) shares jumped after its results beat estimates and ended a run of three straight declines in annual revenue. The company reported revenue of $3.6 billion in its fiscal fourth quarter and adjusted earnings per share of $0.39, which topped expectations. The company reaffirmed guidance for organic net sales growth and raised guidance on its adjusted operating margin, with analysts saying a steady recovery is underway. - TJ Maxx (TJX) shares fall 0.84% in Wednesday trading after the clothing retailer reported second-quarter comparable sales for its Marmaxx segment, which includes TJ Maxx and Marshalls, that missed the average analyst estimate.

Listen for five-minute conversations on today's biggest winners and losers in the stock market. 

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Listen for five-minute conversations on today's biggest winners and losers in the stock market.&nbsp;
Subscribe for analysis on the companies making news in global equity markets. Episodes are published throughout the day to track stock moves from New York, London, Frankfurt and Paris. Join us for investment news covering technology, energy, finance, health care, communications, industrials, utilities, consumer staples, materials, real estate and more.

Listen for news on today's biggest winners and losers in the stock market.

Stock Movers

Closing Bell: Moderna Surges, Estee Lauder Soars, TJ Maxx Declines

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