Today's biggest winners and losers in the stock market:

- Advanced Micro Devices (AMD) shares sink afterhours after a disappointing forecast for the current period, a sign it’s not making the kind of AI inroads that some investors anticipated.

- Novo Nordisk (NVO) ADRs tumble after an early release of its results, which were scheduled for Wednesday. The company said its sales will drop this year as its blockbusters Ozempic and Wegovy face ever-tougher competition and the company gets hit by the US government’s push to cut drug prices.

- PayPal (PYPL) shares plunge after the company announced HP Chief Executive Officer Enrique Lores will take the top job from Alex Chriss, whose turnaround plan failed to meet targets and streamline the sprawling payments business, and a separate statement showing fourth-quarter profit and revenue missed analysts’ estimates.