Orexin is a 'master controller' of the sleep wake control system. It stimulates the wake-promoting system and stabilises the switching between wake and sleep. The unique role of orexin makes it an attractive target for manipulating sleep. Blocking orexin has been shown to be an effective strategy in insomnia, and drugs that block orexin, like suvorexant (Belsomra), are now available. Orexin replacement will also play a key role in managing narcolepsy in the future.

Dr Moira Junge (Health Psychologist) and Dr David Cunnington (Sleep Physician) host the monthly podcast, Sleep Talk, talking all things sleep.

Leave a review and subscribe via iTunes

Audio Timeline:
00:00 - 01:25 Introduction
01:25 - 07:43 What's news in sleep?

01:25 - 02:53 SCN2a gene mutation / sleep for carers
02:53 - 04:14 Sleep in Australians - Sleep Health Foundation research
04:14 - 05:17 World Sleep Day - Sleep Health Foundation campaign
05:17 - 07:13 Melatonin - TGA registration
07:13 - 07:43 Sleep walking research
07:43 -  36:44 Theme - Orexin & Suvorexant

07:43 - 12:07 Sleep wake regulation and role of orexin
12:07 - 25:51 Guest interview - Daniel Hoyer: Orexin
25:51 - 34:05 Clinical use of suvorexant (Belsomra)
34:05 - 36:44 Orexin replacement in narcolepsy
36:44 - 37:56 Clinical tip of the month - Map sleep symptoms to brain systems
37:56 - 37:58 Pick of the month:

37:56 - 40:35 Moira - Insomniac City - Book
40:35 - 44:46 David - Sleep in Primitive Societies - journal article
44:46 - 46:52 What's coming up in sleep?

Next episode: April 3rd 2017 - Headaches and Sleep

Links mentioned in the podcast:
SCN2a gene mutation
Australian Sleep Health Survey
Sleep Health Foundation - Swap screen time for sleep time
Melatonin - TGA registration in Australia
Melatonin for sleep - SleepHub post
Sleep walking research
Prof Daniel Hoyer - Key research publications
Suvorexant (Belsomra) approval - FDA (United States)
Suvorexant (Belsomra) - US Consumer Reports
Suvorexant (Belsomra) - The New Daily on Belsomra in Australia
Consumer Medicine Information on Belsomra - Australia
Medication for Insomnia - SleepHub post
Cognitive Behavioural Therapy for Insomnia - SleepHub post
Medication for narcolepsy - SleepHub post
Neurological Regulation of Sleep - Nature paper by Saper et al
Suvorexant - SleepHub post
Orexin - SleepHub post
Assessing Sleep Disorders - Video
Insomniac City - Book
Sleep in Primitive Societies - American Journal of Human Biology
Sleep Down Under 2017 meeting - Auckland Oct 25-28
Sleep 2017 meeting - Boston June 3-7
World Sleep Congress 2017 - Prague October 7-11

Orexin is a 'master controller' of the sleep wake control system. It&nbsp;stimulates the wake-promoting system and stabilises the switching between wake and sleep. The unique role of orexin makes it an attractive target for manipulating sleep. Blocking orexin has been shown to be an effective strategy in insomnia, and drugs that block orexin, like suvorexant (Belsomra), are now available. Orexin replacement will also play a key role in managing narcolepsy in the future.
Dr Moira Junge (Health Psychologist) and Dr David Cunnington (Sleep Physician) host the monthly podcast, Sleep Talk, talking all things sleep.
Leave a review and&nbsp;subscribe via&nbsp;<a href="https://itunes.apple.com/au/podcast/sleep-talk/id1067640419?mt=2">iTunes</a>
Audio Timeline:
<ul>
<li>00:00 - 01:25 Introduction</li>
<li>01:25 - 07:43 What's news in sleep?
<ul>
<li>01:25 - 02:53&nbsp;SCN2a gene mutation / sleep for carers</li>
<li>02:53 - 04:14&nbsp;Sleep in Australians - Sleep Health Foundation research</li>
<li>04:14 - 05:17 World Sleep Day - Sleep Health Foundation campaign</li>
<li>05:17 - 07:13 Melatonin - TGA registration</li>
<li>07:13 - 07:43&nbsp;Sleep walking research</li>
</ul>
</li>
<li>07:43 - &nbsp;36:44 Theme&nbsp;-&nbsp;Orexin &amp; Suvorexant
<ul>
<li>07:43&nbsp;- 12:07 Sleep wake regulation and role of orexin</li>
<li>12:07 - 25:51 Guest interview - Daniel Hoyer: Orexin</li>
<li>25:51 - 34:05&nbsp;Clinical use of suvorexant (Belsomra)</li>
<li>34:05 - 36:44 Orexin replacement in narcolepsy</li>
</ul>
</li>
<li>36:44 - 37:56 Clinical tip of the month - Map sleep symptoms to brain systems</li>
<li>37:56 - 37:58 Pick&nbsp;of the month:
<ul>
<li>37:56 - 40:35 Moira -&nbsp;Insomniac City&nbsp;- Book</li>
<li>40:35 - 44:46 David -&nbsp;Sleep in Primitive Societies - journal article</li>
</ul>
</li>
<li>44:46 - 46:52&nbsp;What's coming up in sleep?</li>
</ul>
Next episode: April 3rd&nbsp;2017 - Headaches and Sleep
Links mentioned in the podcast:
<ul>
<li><a href="http://www.supportepilepsy.com.au/event/SCN2a">SCN2a gene mutation</a></li>
<li><a href="http://www.sleephealthfoundation.org.au/pdfs/surveys/SleepHealthFoundation-Survey.pdf">Australian Sleep Health Survey</a></li>
<li><a href="http://www.sleephealthfoundation.org.au">Sleep Health Foundation</a>&nbsp;- Swap screen time for sleep time</li>
<li><a href="https://www.tga.gov.au/book-page/32-melatonin">Melatonin</a>&nbsp;- TGA registration in Australia</li>
<li><a href="http://sleephub.com.au/melatonin/">Melatonin for sleep</a>&nbsp;- SleepHub post</li>
<li><a href="https://monashsleepstudy.wordpress.com">Sleep walking research</a></li>
<li><a href="http://findanexpert.unimelb.edu.au/display/person553058">Prof Daniel Hoyer</a>&nbsp;- Key research publications</li>
<li><a href="https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm409950.htm">Suvorexant (Belsomra) approval</a>&nbsp;- FDA (United States)</li>
<li><a href="http://www.consumerreports.org/cro/news/2015/07/skip-new-insomnia-drug-belsomra/index.htm">Suvorexant (Belsomra)</a>&nbsp;- US Consumer Reports</li>
<li><a href="http://thenewdaily.com.au/life/wellbeing/2016/12/02/belsomra-sleeping-pill-australia/">Suvorexant (Belsomra)</a>&nbsp;-&nbsp;The New Daily on Belsomra in Australia</li>
<li><a href="http://www.medicines.org.au/product.cfm?type=cmi&amp;handle=mkcbelso#">Consumer Medicine Information on Belsomra</a>&nbsp;- Australia</li>
<li><a href="http://sleephub.com.au/medication-for-insomnia/">Medication for Insomnia</a>&nbsp;- SleepHub post</li>
<li><a href="http://sleephub.com.au/cognitive-behavioural-therapy-for-insomnia/">Cognitive Behavioural Therapy for Insomnia</a>&nbsp;- SleepHub post</li>
<li><a href="http://sleephub.com.au/wake-promoting-medication/">Medication for narcolepsy</a>&nbsp;- SleepHub post</li>
<li><a href="http://www.nature.com/nature/journal/v437/n7063/full/nature04284.html">Neurological Regulation of Sleep</a>&nbsp;- Nature paper by Saper et al</li>
<li><a href="http://sleephub.com.au/suvorexant/">Suvorexant</a>&nbsp;- SleepHub post</li>
<li><a href="http://sleephub.com.au/orexin/">Orexin</a>&nbsp;- SleepHub post</li>
<li><a href="http://sleephub.com.au/assessing-sleep-disorders/">Assessing Sleep Disorders</a>&nbsp;- Video</li>
<li><a href="http://www.bloomsbury.com/us/insomniac-city-9781620404959/">Insomniac City</a>&nbsp;-&nbsp;Book</li>
<li><a href="http://onlinelibrary.wiley.com/doi/10.1002/ajhb.22979/full">Sleep in Primitive Societies</a>&nbsp;- American Journal of Human Biology</li>
<li><a href="http://www.sleepdownunder.com">Sleep Down Under 2017 meeting</a>&nbsp;- Auckland Oct 25-28</li>
<li><a href="http://www.sleepmeeting.org">Sleep 2017 meeting</a>&nbsp;- Boston June 3-7</li>
<li><a href="https://worldsleepcongress.com">World Sleep Congress 2017</a>&nbsp;- Prague October 7-11</li>
</ul>

Sleep Talk is the place to get quality, evidence-based information on sleep and sleep disorders from experts in the field. Each month Dr Moira Junge (Health Psychologist) and Dr David Cunnington (Sleep Physician) discuss a sleep topic and interview experts in the field as well as highlighting what has caught their eye in the world of sleep.

Tune in each month for information on health sleep and sleep disorders.

Sleep Talk - Talking all things sleep

Sleep Talk is the place to get quality, evidence-based information on sleep and sleep disorders from experts in the field. Each month Dr Moira Junge (Health Psychologist) and Dr David Cunnington (Sleep Physician) discuss a sleep topic and interview experts in the field as well as highlighting what has caught their eye in the world of sleep. Brought to you by SleepHub.com.au

Sleep Talk

Orexin is a 'master controller' of the sleep wake control system. It stimulates the wake-promoting system and stabilises the switching between wake and sleep. The unique role of orexin makes it an attractive target for manipulating sleep. Blocking orexin has been shown to be an effective strategy in insomnia, and drugs that block orexin, like suvorexant (Belsomra), are now available. Orexin replacement will also play a key role in managing narcolepsy in the future.