Poop pills could save your life, but first you need a complete flush. You're prepping for treatment. Drinking the same bowel prep solution people drink before colonoscopies. You're clearing out your native microbiome. Making room. Tomorrow you'll sit in the clinic on an empty stomach and swallow donor bacteria packaged in capsules. Thirty-five pills. One hour. Your cancer is advanced. Your immunotherapy has been struggling. Your gut went from healthy ecosystem to diseased, inflammatory wreck when cancer became chronic. The bacteria you need don't live there anymore.

The donor stool gets processed to pure microbial components, frozen in triple-layer capsules until your treatment day. If engraftment succeeds (donor microbiome colonizes and thrives), you respond significantly better. Nature Medicine published the data. Melanoma patients. Kidney cancer patients. Those with successful engraftment experienced fewer side effects, better outcomes. Those without? Pills didn't take. Treatment kept struggling.

Your gut is your biggest immune organ. Trillions of bacteria produce metabolites that travel through your bloodstream to your brain, your organs, everywhere. The gut-brain axis is real. When those bacteria fail, your immune system fails. Immunotherapy requires a functioning immune system to kill cancer. Maleki's team now testing the same approach for IBD, MS, ALS.

Topics: poop pills cancer, microbiome treatment, immune system restoration, bacterial therapy, inflammatory disease

GUEST: Dr. Saman Maleki | @‌smimmunology

Originally aired on 2026-02-02

Poop pills could save your life, but first you need a complete flush. You're prepping for treatment. Drinking the same bowel prep solution people drink before colonoscopies. You're clearing out your native microbiome. Making room. Tomorrow you'll sit in the clinic on an empty stomach and swallow donor bacteria packaged in capsules. Thirty-five pills. One hour. Your cancer is advanced. Your immunotherapy has been struggling. Your gut went from healthy ecosystem to diseased, inflammatory wreck when cancer became chronic. The bacteria you need don't live there anymore.
The donor stool gets processed to pure microbial components, frozen in triple-layer capsules until your treatment day. If engraftment succeeds (donor microbiome colonizes and thrives), you respond significantly better. Nature Medicine published the data. Melanoma patients. Kidney cancer patients. Those with successful engraftment experienced fewer side effects, better outcomes. Those without? Pills didn't take. Treatment kept struggling.
Your gut is your biggest immune organ. Trillions of bacteria produce metabolites that travel through your bloodstream to your brain, your organs, everywhere. The gut-brain axis is real. When those bacteria fail, your immune system fails. Immunotherapy requires a functioning immune system to kill cancer. Maleki's team now testing the same approach for IBD, MS, ALS.
Topics: poop pills cancer, microbiome treatment, immune system restoration, bacterial therapy, inflammatory disease
GUEST: Dr. Saman Maleki | @&zwnj;smimmunology
Originally aired on&nbsp;2026-02-02

Shane Hewitt & The Nightshift is your late-night companion for real talk, bold ideas, and unfiltered conversations that matter. Hosted by Canadian radio veteran Shane Hewitt, each episode dives into the headlines, human stories, and hidden truths shaping our world—always with curiosity, compassion, and a sharp edge.

From politics and pop culture to mental health, technology, and everyday life, this podcast is where night owls, deep thinkers, and curious minds come to connect. Featuring expert guests, passionate callers, and Shane’s signature style—thoughtful, fearless, and refreshingly real.

If you crave meaningful dialogue, smart perspectives, and late-night radio energy in podcast form, subscribe now and join The Nightshift.

Shane Hewitt &amp; The Nightshift is your late-night companion for real talk, bold ideas, and unfiltered conversations that matter. Hosted by Canadian radio veteran Shane Hewitt, each episode dives into the headlines, human stories, and hidden truths shaping our world&mdash;always with curiosity, compassion, and a sharp edge.
From politics and pop culture to mental health, technology, and everyday life, this podcast is where night owls, deep thinkers, and curious minds come to connect. Featuring expert guests, passionate callers, and Shane&rsquo;s signature style&mdash;thoughtful, fearless, and refreshingly real.
If you crave meaningful dialogue, smart perspectives, and late-night radio energy in podcast form, subscribe now and join The Nightshift.

Shane Hewitt and The Nightshift

Shane Hewitt is known for his engaging and relatable on-air personality, which captivates listeners. His ability to blend insightful commentary with humour and empathy creates a genuine connection with listeners.  Shane Hewitt and the Night Shift provides relatable content, informative discussions and expert insights – along with a balance of anecdotes and entertainment.

Shane Hewitt is known for his engaging and relatable on-air personality, which captivates listeners. His ability to blend insightful commentary with humour and empathy creates a genuine connection with listeners.  Shane Hewitt and the Night Shift provides relatable content, informative discussions and expert insights – along with a balance of anecdotes and entertainment.