What really separates roflumilast (Zoryve) from other PDE4 inhibitors — and why does it matter for your patients with atopic dermatitis, psoriasis, or seborrheic dermatitis? In this episode, Dr. Ted Lane sits down with Dr. Chris Bunick, Associate Professor of Dermatology at Yale School of Medicine and Editor-in-Chief of Dermatology Times, for a deep dive into the biochemistry, formulation science, and clinical implications behind this breakthrough topical treatment.

In this episode, you'll learn:
Why roflumilast binds PDE4 with 200x more potency than apremilast — and 1,000x more than crisaborole
How cyclic AMP inhibition controls upstream cytokine pathways (TH1, TH2, TH17) across multiple inflammatory skin diseases
The science behind the Crotofos emulsifier — and why the right emulsifier protects the skin barrier instead of stripping ceramides
Why formulating at pH 5.5 matters for filaggrin, keratin, and barrier integrity
How the roflumilast foam is specifically engineered for scalp conditions and hair-bearing areas
What's next in topical formulation innovation — from targeted dermal delivery to longevity skincare

Whether you're a dermatologist, resident, PA, NP, or skincare enthusiast who wants to understand the why behind cutting-edge topicals, this episode is packed with clinical and scientific insight you won't find anywhere else.

🎙️ This episode is sponsored by Arcutis Biotherapeutics, maker of roflumilast cream and foam.

📧 Send your questions to: questions@scienceofskinnsummit.com

📅 Science of Skin Summit — September 19–21, Austin, TX

📅 Longevity Meeting — February 19 - 21, Scottsdale, AZ

Subscribe, leave a 5-star review, and follow Dr. Bunick's podcast: ABCDs in Dermatology.

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

What really separates roflumilast (Zoryve) from other PDE4 inhibitors &mdash; and why does it matter for your patients with atopic dermatitis, psoriasis, or seborrheic dermatitis? In this episode, Dr. Ted Lane sits down with Dr. Chris Bunick, Associate Professor of Dermatology at Yale School of Medicine and Editor-in-Chief of Dermatology Times, for a deep dive into the biochemistry, formulation science, and clinical implications behind this breakthrough topical treatment.
In this episode, you'll learn:
<ul>
<li>Why roflumilast binds PDE4 with 200x more potency than apremilast &mdash; and 1,000x more than crisaborole</li>
<li>How cyclic AMP inhibition controls upstream cytokine pathways (TH1, TH2, TH17) across multiple inflammatory skin diseases</li>
<li>The science behind the Crotofos emulsifier &mdash; and why the right emulsifier protects the skin barrier instead of stripping ceramides</li>
<li>Why formulating at pH 5.5 matters for filaggrin, keratin, and barrier integrity</li>
<li>How the roflumilast foam is specifically engineered for scalp conditions and hair-bearing areas</li>
<li>What's next in topical formulation innovation &mdash; from targeted dermal delivery to longevity skincare</li>
</ul>
Whether you're a dermatologist, resident, PA, NP, or skincare enthusiast who wants to understand the why behind cutting-edge topicals, this episode is packed with clinical and scientific insight you won't find anywhere else.
🎙️ This episode is sponsored by Arcutis Biotherapeutics, maker of roflumilast cream and foam.
📧 Send your questions to: <a href="mailto:questions@scienceofskinnsummit.com">questions@scienceofskinnsummit.com</a>
📅 Science of Skin Summit &mdash; September 19&ndash;21, Austin, TX
📅 Longevity Meeting &mdash; February 19 - 21, Scottsdale, AZ
Subscribe, leave a 5-star review, and follow Dr. Bunick's podcast: ABCDs in Dermatology.
Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

The Science of Skin is a podcast for those who want to be in-the-know about what’s trending, and what’s next in topical skincare.  Hosts  Dr. Patti Farris and Dr. Ted Lain are board certified dermatologist, recognized experts in topical skincare and co-founders of the Science of Skin Summit. In each episode, The Science of Skin will give you an insider’s view of the skincare industry.  You will hear from research scientists, formulators, and leading physician experts on how products are developed, tested, and used to treat medical and cosmetic patients.  

So, if you’re interested in a behind the scenes look at what makes the skincare industry tick, subscribe to The Science of Skin today. Thanks for listening!

 

You can slo find us on YouTube: https://www.youtube.com/@scienceofskinpodcast

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

The Science of Skin is a podcast for those who want to be in-the-know about what&rsquo;s trending, and what&rsquo;s next in topical skincare.&nbsp; Hosts &nbsp;Dr. Patti Farris and Dr. Ted Lain are board certified dermatologist, recognized experts in topical skincare and co-founders of the <a href="https://scienceofskincaresummit.com/">Science of Skin Summit</a>. In each episode, The Science of Skin will give you an insider&rsquo;s view of the skincare industry.&nbsp; You will hear from research scientists, formulators, and leading physician experts on how products are developed, tested, and used to treat medical and cosmetic patients. &nbsp;
So, if you&rsquo;re interested in a behind the scenes look at what makes the skincare industry tick, subscribe to The Science of Skin today. Thanks for listening!
&nbsp;
You can slo find us on YouTube: <a href="https://www.youtube.com/@scienceofskinpodcast">https://www.youtube.com/@scienceofskinpodcast</a>
Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

The Science of Skin

The Science of Skin is a podcast for those who want to be in-the-know about what’s trending, and what’s next in topical skincare.  Hosts  Dr. Patti Farris and Dr. Ted Lain are board certified dermatologist, recognized experts in topical skincare and co-founders of the Science of Skin Summit. In each episode, The Science of Skin will give you an insider’s view of the skincare industry.  You will hear from research scientists, formulators, and leading physician experts on how products are developed, tested, and used to treat medical and cosmetic patients.  

So, if you’re interested in a behind the scenes look at what makes the skincare industry tick, subscribe to The Science of Skin today. Thanks for listening!

You can also find us on YouTube: https://www.youtube.com/@scienceofskinpodcast

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

The Science of Skin is a podcast for those who want to be in-the-know about what&rsquo;s trending, and what&rsquo;s next in topical skincare.&nbsp; Hosts &nbsp;Dr. Patti Farris and Dr. Ted Lain are board certified dermatologist, recognized experts in topical skincare and co-founders of the <a href="https://scienceofskincaresummit.com/">Science of Skin Summit</a>. In each episode, The Science of Skin will give you an insider&rsquo;s view of the skincare industry.&nbsp; You will hear from research scientists, formulators, and leading physician experts on how products are developed, tested, and used to treat medical and cosmetic patients. &nbsp;
So, if you&rsquo;re interested in a behind the scenes look at what makes the skincare industry tick, subscribe to The Science of Skin today. Thanks for listening!
You can also find us on YouTube: <a href="https://www.youtube.com/@scienceofskinpodcast">https://www.youtube.com/@scienceofskinpodcast</a>
Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.