Could GLP-1 medications be the missing piece in treating inflammatory skin disease? In this episode of Science is Skin, Dr. Ted Lain sits down with Dr. Lindsey Bordone — former Columbia University associate professor of dermatology, now in private practice at Bordone Dermatology in Scottsdale, Arizona — for a deep dive into metabolic disease and the skin.

Dr. Bordone was among the first dermatologists to prescribe GLP-1 agonists for her patients, and in this conversation she explains exactly why. From the link between hyperinsulinemia and chronic inflammation to the visible skin signs of insulin resistance — skin tags, acanthosis nigricans, forearm hair loss — she makes the case that dermatologists are uniquely positioned to catch metabolic disease before any other specialty.

Dr. Bordone walks through how she uses tirzepatide (Mounjaro/Zepbound), semaglutide (Ozempic/Wegovy), and the emerging triple-G drug retatrutide, including her lab protocols, dosing philosophy, how to manage GI side effects, and the surprising interaction between GLP-1s and estrogen therapy.

In this episode:
Why high BMI reduces biologic efficacy in psoriasis patients
How to check fasting insulin (HOMA-IR) and why most physicians aren't doing it
Skin signs of insulin resistance: skin tags, forearm hair loss, and neck skin thickening
Tirzepatide vs. semaglutide vs. retatrutide — how to choose and when
Retatrutide's remarkable 93% fatty liver clearance rate in clinical trials
The truth about sarcopenia and muscle loss on GLP-1 medications
Dosing protocols, side effect management, and when NOT to escalate quickly
Protein intake recommendations during active weight loss
Estrogen and GLP-1 synergy — what dermatologists need to know
Lab work to run before and during GLP-1 therapy
How to build an insurance case for continued medication coverage

Resources mentioned:
HOMA-IR fasting insulin/glucose testing
AAD resources on metabolic dermatology
Bordone Dermatology — Scottsdale, Arizona

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To watch this and other episodes, be sure to check out our YouTube page 

DISCLAIMER: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

Could GLP-1 medications be the missing piece in treating inflammatory skin disease? In this episode of Science is Skin, Dr. Ted Lain sits down with Dr. Lindsey Bordone &mdash; former Columbia University associate professor of dermatology, now in private practice at Bordone Dermatology in Scottsdale, Arizona &mdash; for a deep dive into metabolic disease and the skin.
Dr. Bordone was among the first dermatologists to prescribe GLP-1 agonists for her patients, and in this conversation she explains exactly why. From the link between hyperinsulinemia and chronic inflammation to the visible skin signs of insulin resistance &mdash; skin tags, acanthosis nigricans, forearm hair loss &mdash; she makes the case that dermatologists are uniquely positioned to catch metabolic disease before any other specialty.
Dr. Bordone walks through how she uses tirzepatide (Mounjaro/Zepbound), semaglutide (Ozempic/Wegovy), and the emerging triple-G drug retatrutide, including her lab protocols, dosing philosophy, how to manage GI side effects, and the surprising interaction between GLP-1s and estrogen therapy.
In this episode:
<ul>
<li>Why high BMI reduces biologic efficacy in psoriasis patients</li>
<li>How to check fasting insulin (HOMA-IR) and why most physicians aren't doing it</li>
<li>Skin signs of insulin resistance: skin tags, forearm hair loss, and neck skin thickening</li>
<li>Tirzepatide vs. semaglutide vs. retatrutide &mdash; how to choose and when</li>
<li>Retatrutide's remarkable 93% fatty liver clearance rate in clinical trials</li>
<li>The truth about sarcopenia and muscle loss on GLP-1 medications</li>
<li>Dosing protocols, side effect management, and when NOT to escalate quickly</li>
<li>Protein intake recommendations during active weight loss</li>
<li>Estrogen and GLP-1 synergy &mdash; what dermatologists need to know</li>
<li>Lab work to run before and during GLP-1 therapy</li>
<li>How to build an insurance case for continued medication coverage</li>
</ul>
Resources mentioned:
<ul>
<li>HOMA-IR fasting insulin/glucose testing</li>
<li>AAD resources on metabolic dermatology</li>
<li>Bordone Dermatology &mdash; Scottsdale, Arizona</li>
</ul>
Enjoyed this episode? Share it with a colleague and leave us a five-star review. Subscribe so you never miss an episode of Science is Skin.
To watch this and other episodes, be sure to check out our&nbsp;<a href="https://www.youtube.com/@scienceofskinpodcast">YouTube</a> page&nbsp;
DISCLAIMER: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

The Science of Skin is a podcast for those who want to be in-the-know about what’s trending, and what’s next in topical skincare.  Hosts  Dr. Patti Farris and Dr. Ted Lain are board certified dermatologist, recognized experts in topical skincare and co-founders of the Science of Skin Summit. In each episode, The Science of Skin will give you an insider’s view of the skincare industry.  You will hear from research scientists, formulators, and leading physician experts on how products are developed, tested, and used to treat medical and cosmetic patients.  

So, if you’re interested in a behind the scenes look at what makes the skincare industry tick, subscribe to The Science of Skin today. Thanks for listening!

 

You can slo find us on YouTube: https://www.youtube.com/@scienceofskinpodcast

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

The Science of Skin is a podcast for those who want to be in-the-know about what&rsquo;s trending, and what&rsquo;s next in topical skincare.&nbsp; Hosts &nbsp;Dr. Patti Farris and Dr. Ted Lain are board certified dermatologist, recognized experts in topical skincare and co-founders of the <a href="https://scienceofskincaresummit.com/">Science of Skin Summit</a>. In each episode, The Science of Skin will give you an insider&rsquo;s view of the skincare industry.&nbsp; You will hear from research scientists, formulators, and leading physician experts on how products are developed, tested, and used to treat medical and cosmetic patients. &nbsp;
So, if you&rsquo;re interested in a behind the scenes look at what makes the skincare industry tick, subscribe to The Science of Skin today. Thanks for listening!
&nbsp;
You can slo find us on YouTube: <a href="https://www.youtube.com/@scienceofskinpodcast">https://www.youtube.com/@scienceofskinpodcast</a>
Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

The Science of Skin

The Science of Skin is a podcast for those who want to be in-the-know about what’s trending, and what’s next in topical skincare.  Hosts  Dr. Patti Farris and Dr. Ted Lain are board certified dermatologist, recognized experts in topical skincare and co-founders of the Science of Skin Summit. In each episode, The Science of Skin will give you an insider’s view of the skincare industry.  You will hear from research scientists, formulators, and leading physician experts on how products are developed, tested, and used to treat medical and cosmetic patients.  

So, if you’re interested in a behind the scenes look at what makes the skincare industry tick, subscribe to The Science of Skin today. Thanks for listening!

You can also find us on YouTube: https://www.youtube.com/@scienceofskinpodcast

Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

The Science of Skin is a podcast for those who want to be in-the-know about what&rsquo;s trending, and what&rsquo;s next in topical skincare.&nbsp; Hosts &nbsp;Dr. Patti Farris and Dr. Ted Lain are board certified dermatologist, recognized experts in topical skincare and co-founders of the <a href="https://scienceofskincaresummit.com/">Science of Skin Summit</a>. In each episode, The Science of Skin will give you an insider&rsquo;s view of the skincare industry.&nbsp; You will hear from research scientists, formulators, and leading physician experts on how products are developed, tested, and used to treat medical and cosmetic patients. &nbsp;
So, if you&rsquo;re interested in a behind the scenes look at what makes the skincare industry tick, subscribe to The Science of Skin today. Thanks for listening!
You can also find us on YouTube: <a href="https://www.youtube.com/@scienceofskinpodcast">https://www.youtube.com/@scienceofskinpodcast</a>
Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.