Did you know women are twice as likely to develop Alzheimer's disease as men, and oestrogen may be a key reason why? In this episode, Dr Lucy Burns and Dr Mary Barson break down the real science behind oestrogen's role in brain health and dementia prevention, why the infamous 2003 WHI study sent doctors running scared for decades, and what the latest evidence actually means for women in midlife. If MHT is not right for you, don't worry, protecting your brain is never a one-trick pony. This is the episode every woman in midlife needs to hear. 

Research mentioned in this episode: 
Paganini-Hill A, Henderson VW. Archives of Internal Medicine. 1996 
Kim YJ et al. Alzheimer's & Dementia. 2021 
Nerattini M et al. Frontiers in Aging Neuroscience. 2023 
Cipriano GL et al. International Journal of Molecular Sciences. 2024 
Melville NA et al. The Lancet Healthy Longevity. 2025 

For more information about Real Life Medicine and our programs and special offers: https://www.rlmedicine.com/ 

Episode, show notes & transcript 
https://www.rlmedicine.com/can-hrt-prevent-dementia 

Did you know women are twice as likely to develop Alzheimer's disease as men, and oestrogen may be a key reason why? In this episode, Dr Lucy Burns and Dr Mary Barson break down the real science behind oestrogen's role in brain health and dementia prevention, why the infamous 2003 WHI study sent doctors running scared for decades, and what the latest evidence actually means for women in midlife. If MHT is not right for you, don't worry, protecting your brain is never a one-trick pony. This is the episode every woman in midlife needs to hear.&nbsp;
Research mentioned in this episode:&nbsp;
<ul>
<li>Paganini-Hill A, Henderson VW. Archives of Internal Medicine. 1996&nbsp;</li>
<li>Kim YJ et al. Alzheimer's &amp; Dementia. 2021&nbsp;</li>
<li>Nerattini M et al. Frontiers in Aging Neuroscience. 2023&nbsp;</li>
<li>Cipriano GL et al. International Journal of Molecular Sciences. 2024&nbsp;</li>
<li>Melville NA et al. The Lancet Healthy Longevity. 2025&nbsp;</li>
</ul>
For more information about Real Life Medicine and our programs and special offers:&nbsp;<a href="https://www.rlmedicine.com/">https://www.rlmedicine.com/</a>&nbsp;
Episode, show notes &amp; transcript <a href="https://www.rlmedicine.com/can-hrt-prevent-dementia">https://www.rlmedicine.com/can-hrt-prevent-dementia</a>&nbsp;

Welcome to the Real Health and Weight Loss Podcast where you get Real advice from Real Doctors to help you lose weight and revolutionise your health not just now but permanently. You can change your future, starting now. 

Imagine if everything you had been told about weight loss was wrong. 

We are here to bust through some myths and give you actionable advice. Real health and weight loss is a journey and we, your hosts Dr Mary Barson and Dr Lucy Burns from Real Life Medicine, are here with you every step of the way. 

Welcome to the Real Health and Weight Loss Podcast where you get Real advice from Real Doctors to help you lose weight and revolutionise your health not just now but permanently. You can change your future, starting now.&nbsp;
Imagine if everything you had been told about weight loss was wrong.&nbsp;
We are here to bust through some myths and give you actionable advice. Real health and weight loss is a journey and we, your hosts Dr Mary Barson and Dr Lucy Burns from Real Life Medicine, are here with you every step of the way.&nbsp;

Real health from real doctors on health and weight loss

Real Health and Weight Loss Podcast

Welcome to the Real Health and Weight Loss where you get Real advice from Real Doctors to help you lose weight and revolutionise your health not just now but permanently. You can change your future, starting now. Imagine if everything you had been told about weight loss was wrong.

We are here to bust through some myths and give you actionable advice. Real Health and weight loss is a journey and we, your hosts Dr Mary Barson and Dr Lucy Burns from Real Life Medicine are here with you every step of the way. 

Welcome to the Real Health and Weight Loss where you get Real advice from Real Doctors to help you lose weight and revolutionise your health not just now but permanently. You can change your future, starting now. Imagine if everything you had been told about weight loss was wrong.
We are here to bust through some myths and give you actionable advice. Real Health and weight loss is a journey and we, your hosts Dr Mary Barson and Dr Lucy Burns from Real Life Medicine are here with you every step of the way.&nbsp;